Trans, and n-3 polyunsaturated fatty acids and vascular function - a yin yang situation?

Jørn Dyerberg, Jeppe H. Christensen, Dorte Eskesen, Arne Astrup, Steen Stender

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    11 Citationer (Scopus)

    Abstract

    Trans fatty acids (TFA) and n-3 polyunsaturated fatty acids (n-3 PUFA) have opposite effects on several biological functions. We report a study on the effects on risk markers for cardiovascular disease. Eighty-seven healthy males were randomly assigned to 8 weeks of daily intake of either 20 g of industrially produced TFA (IP-TFA), 4 g n-3 PUFA, or control fat, incorporated in bakery products as part of the daily food.

    High-density lipoprotein cholesterol decreased in the TFA-group, triglycerides and mean arterial blood pressure decreased in the n-3 group. Heart rate variability (HRV), arterial dilatory capacity, flow mediated vasodilation, compliance, and distensibility were unchanged.

    Post hoc, we did a subgroup analysis of the results from the subjects with normal initial HRV. In these, 24-h heart rate (HR) was significantly increased by approximately three beats/min in the TFA group, with a decrease of the same magnitude in the n-3 group. A high HR is associated to an increased mortality and vice versa.

    Our results thus support the notion that IP-TFA and n-3 PUFA affect risk for cardiovascular mortality via mechanisms not only related to changes in plasma concentrations of lipids and lipoproteins.
    OriginalsprogEngelsk
    TidsskriftAtherosclerosis - Supplements
    Vol/bind7
    Udgave nummer2
    Sider (fra-til)33-35
    Antal sider3
    ISSN1567-5688
    DOI
    StatusUdgivet - 2006

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