Ivermectin and albendazole alone and in combination for the treatment of lymphatic filariasis in Ghana: follow-up after re-treatment with the combination

Samuel K Dunyo, Paul Erik Simonsen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

10 Citationer (Scopus)

Abstract

The efficacy of re-treatment with the combination of ivermectin (150-200 micrograms/kg bodyweight) and albendazole (400 mg) on Wuchereria bancrofti microfilaraemia was assessed in 1997-99 in 4 groups of individuals from coastal Ghana, which 1 year previously had received a primary treatment with placebo (n = 38), albendazole (n = 39), ivermectin (n = 34) or combination of albendazole and ivermectin (n = 42), respectively. One year after the re-treatment, an overall mean reduction in microfilarial intensity of 76.2% in relation to the intensity before re-treatment was observed, with no statistical significant difference between the 4 groups. The groups given primary treatment with placebo or the drug combination showed re-treatment reductions which were lower (72.5% and 69.8%, respectively) but not statistically significantly different from the reduction observed 1 year after the primary treatment with the combination (86.7%). The efficacy of the combination treatment thus appeared to be largely independent of the type of primary treatment given and multiplicative when used repeatedly.
OriginalsprogEngelsk
TidsskriftTransactions of the Royal Society of Tropical Medicine and Hygiene
Vol/bind96
Udgave nummer2
Sider (fra-til)189-92
Antal sider4
ISSN0035-9203
StatusUdgivet - 2002
Udgivet eksterntJa

Citationsformater