Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G >C with circulating glucose levels, interleukin-6 levels, and body mass index.

Cornelia Huth; Thomas Illig; Christian Herder; Christian Gieger; Harald Grallert; Caren Vollmert; Wolfgang Rathmann; Yasmin Hamid; Oluf Pedersen; Torben Hansen; Barbara Thorand; Christa Meisinger; Angela Doring; Norman Klopp; Henning Gohlke; Wolfgang Lieb; Christian Hengstenberg; Valeriya Lyssenko; Leif Groop; Helen Ireland; Jeffrey Stephens; Ingrid Wernstedt Asterholm; John-Olov Jansson; Heiner Boeing; Matthias Mohlig; Heather Stringham; Michael Boehnke; Jaakko Tuomilehto; Jose-Manuel Fernandez-Real; Abel Lopez-Bermejo; Luis Gallart; Joan Vendrell; Steve Humphries; Florian Kronenberg; H-Erich Wichmann; Iris Heid

doi:10.1080/07853890802337037

Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G >C with circulating glucose levels, interleukin-6 levels, and body mass index.

Cornelia Huth, Thomas Illig, Christian Herder, Christian Gieger, Harald Grallert, Caren Vollmert, Wolfgang Rathmann, Yasmin Hamid, Oluf Pedersen, Torben Hansen, Barbara Thorand, Christa Meisinger, Angela Doring, Norman Klopp, Henning Gohlke, Wolfgang Lieb, Christian Hengstenberg, Valeriya Lyssenko, Leif Groop, Helen IrelandJeffrey Stephens, Ingrid Wernstedt Asterholm, John-Olov Jansson, Heiner Boeing, Matthias Mohlig, Heather Stringham, Michael Boehnke, Jaakko Tuomilehto, Jose-Manuel Fernandez-Real, Abel Lopez-Bermejo, Luis Gallart, Joan Vendrell, Steve Humphries, Florian Kronenberg, H-Erich Wichmann, Iris Heid

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

50 Citationer (Scopus)

Abstract

Udgivelsesdato: 2008-Aug-27

Originalsprog	Engelsk
Tidsskrift	Annals of Medicine
Vol/bind	41
Sider (fra-til)	128-38
ISSN	0785-3890
DOI	https://doi.org/10.1080/07853890802337037
Status	Udgivet - 2009

Adgang til dokumentet

10.1080/07853890802337037

Citationsformater

Huth, C., Illig, T., Herder, C., Gieger, C., Grallert, H., Vollmert, C., Rathmann, W., Hamid, Y., Pedersen, O., Hansen, T., Thorand, B., Meisinger, C., Doring, A., Klopp, N., Gohlke, H., Lieb, W., Hengstenberg, C., Lyssenko, V., Groop, L., ... Heid, I. (2009). Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G >C with circulating glucose levels, interleukin-6 levels, and body mass index. Annals of Medicine, 41, 128-38. https://doi.org/10.1080/07853890802337037

Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G >C with circulating glucose levels, interleukin-6 levels, and body mass index. / Huth, Cornelia; Illig, Thomas; Herder, Christian et al.
I: Annals of Medicine, Bind 41, 2009, s. 128-38.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Huth, C, Illig, T, Herder, C, Gieger, C, Grallert, H, Vollmert, C, Rathmann, W, Hamid, Y, Pedersen, O, Hansen, T, Thorand, B, Meisinger, C, Doring, A, Klopp, N, Gohlke, H, Lieb, W, Hengstenberg, C, Lyssenko, V, Groop, L, Ireland, H, Stephens, J, Wernstedt Asterholm, I, Jansson, J-O, Boeing, H, Mohlig, M, Stringham, H, Boehnke, M, Tuomilehto, J, Fernandez-Real, J-M, Lopez-Bermejo, A, Gallart, L, Vendrell, J, Humphries, S, Kronenberg, F, Wichmann, H-E & Heid, I 2009, 'Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G >C with circulating glucose levels, interleukin-6 levels, and body mass index.', Annals of Medicine, bind 41, s. 128-38. https://doi.org/10.1080/07853890802337037

@article{d1d28b60acd911ddb538000ea68e967b,

title = "Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G >C with circulating glucose levels, interleukin-6 levels, and body mass index.",

abstract = "Background. Several studies have investigated associations between the -174G >C single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results. Aims. This joint analysis aimed to clarify whether IL6 -174G >C was associated with glucose and circulating interleukin-6 concentrations as well as body mass index (BMI). Methods. Individual-level data from all studies of the IL6-T2DM consortium on Caucasian subjects with available BMI were collected. As study-specific estimates did not show heterogeneity (P>0.1), they were combined by using the inverse-variance fixed-effect model. Results. The main analysis included 9440, 7398, 24,117, or 5659 non-diabetic and manifest T2DM subjects for fasting glucose, 2-hour glucose, BMI, or circulating interleukin-6 levels, respectively. IL6 -174 C-allele carriers had significantly lower fasting glucose (-0.091 mmol/L, P=0.014). There was no evidence for association between IL6 -174G >C and BMI or interleukin-6 levels, except in some subgroups. Conclusions. Our data suggest that C-allele carriers of the IL6 -174G >C polymorphism have lower fasting glucose levels on average, which substantiates previous findings of decreased T2DM risk of these subjects.",

author = "Cornelia Huth and Thomas Illig and Christian Herder and Christian Gieger and Harald Grallert and Caren Vollmert and Wolfgang Rathmann and Yasmin Hamid and Oluf Pedersen and Torben Hansen and Barbara Thorand and Christa Meisinger and Angela Doring and Norman Klopp and Henning Gohlke and Wolfgang Lieb and Christian Hengstenberg and Valeriya Lyssenko and Leif Groop and Helen Ireland and Jeffrey Stephens and {Wernstedt Asterholm}, Ingrid and John-Olov Jansson and Heiner Boeing and Matthias Mohlig and Heather Stringham and Michael Boehnke and Jaakko Tuomilehto and Jose-Manuel Fernandez-Real and Abel Lopez-Bermejo and Luis Gallart and Joan Vendrell and Steve Humphries and Florian Kronenberg and H-Erich Wichmann and Iris Heid",

year = "2009",

doi = "10.1080/07853890802337037",

language = "English",

volume = "41",

pages = "128--38",

journal = "Annals of Medicine",

issn = "0785-3890",

publisher = "Taylor & Francis",

}

TY - JOUR

T1 - Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G >C with circulating glucose levels, interleukin-6 levels, and body mass index.

AU - Huth, Cornelia

AU - Illig, Thomas

AU - Herder, Christian

AU - Gieger, Christian

AU - Grallert, Harald

AU - Vollmert, Caren

AU - Rathmann, Wolfgang

AU - Hamid, Yasmin

AU - Pedersen, Oluf

AU - Hansen, Torben

AU - Thorand, Barbara

AU - Meisinger, Christa

AU - Doring, Angela

AU - Klopp, Norman

AU - Gohlke, Henning

AU - Lieb, Wolfgang

AU - Hengstenberg, Christian

AU - Lyssenko, Valeriya

AU - Groop, Leif

AU - Ireland, Helen

AU - Stephens, Jeffrey

AU - Wernstedt Asterholm, Ingrid

AU - Jansson, John-Olov

AU - Boeing, Heiner

AU - Mohlig, Matthias

AU - Stringham, Heather

AU - Boehnke, Michael

AU - Tuomilehto, Jaakko

AU - Fernandez-Real, Jose-Manuel

AU - Lopez-Bermejo, Abel

AU - Gallart, Luis

AU - Vendrell, Joan

AU - Humphries, Steve

AU - Kronenberg, Florian

AU - Wichmann, H-Erich

AU - Heid, Iris

PY - 2009

Y1 - 2009

N2 - Background. Several studies have investigated associations between the -174G >C single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results. Aims. This joint analysis aimed to clarify whether IL6 -174G >C was associated with glucose and circulating interleukin-6 concentrations as well as body mass index (BMI). Methods. Individual-level data from all studies of the IL6-T2DM consortium on Caucasian subjects with available BMI were collected. As study-specific estimates did not show heterogeneity (P>0.1), they were combined by using the inverse-variance fixed-effect model. Results. The main analysis included 9440, 7398, 24,117, or 5659 non-diabetic and manifest T2DM subjects for fasting glucose, 2-hour glucose, BMI, or circulating interleukin-6 levels, respectively. IL6 -174 C-allele carriers had significantly lower fasting glucose (-0.091 mmol/L, P=0.014). There was no evidence for association between IL6 -174G >C and BMI or interleukin-6 levels, except in some subgroups. Conclusions. Our data suggest that C-allele carriers of the IL6 -174G >C polymorphism have lower fasting glucose levels on average, which substantiates previous findings of decreased T2DM risk of these subjects.

AB - Background. Several studies have investigated associations between the -174G >C single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results. Aims. This joint analysis aimed to clarify whether IL6 -174G >C was associated with glucose and circulating interleukin-6 concentrations as well as body mass index (BMI). Methods. Individual-level data from all studies of the IL6-T2DM consortium on Caucasian subjects with available BMI were collected. As study-specific estimates did not show heterogeneity (P>0.1), they were combined by using the inverse-variance fixed-effect model. Results. The main analysis included 9440, 7398, 24,117, or 5659 non-diabetic and manifest T2DM subjects for fasting glucose, 2-hour glucose, BMI, or circulating interleukin-6 levels, respectively. IL6 -174 C-allele carriers had significantly lower fasting glucose (-0.091 mmol/L, P=0.014). There was no evidence for association between IL6 -174G >C and BMI or interleukin-6 levels, except in some subgroups. Conclusions. Our data suggest that C-allele carriers of the IL6 -174G >C polymorphism have lower fasting glucose levels on average, which substantiates previous findings of decreased T2DM risk of these subjects.

U2 - 10.1080/07853890802337037

DO - 10.1080/07853890802337037

M3 - Journal article

C2 - 18752089

SN - 0785-3890

VL - 41

SP - 128

EP - 138

JO - Annals of Medicine

JF - Annals of Medicine

ER -