TY - JOUR
T1 - Kidney fat by magnetic resonance spectroscopy in type 2 diabetes with chronic kidney disease
AU - Heinrich, Niels Sondergaard
AU - Pedersen, Rune Ploegstra
AU - Vestergaard, Mark Bitsch
AU - Lindberg, Ulrich
AU - Andersen, Ulrik Bjørn
AU - Haddock, Bryan
AU - Fornoni, Alessia
AU - Larsson, Henrik Bo Wiberg
AU - Rossing, Peter
AU - Hansen, Tine Willum
N1 - Publisher Copyright:
© 2024
PY - 2025
Y1 - 2025
N2 - Background and hypothesis: The kidneys may be susceptible to ectopic fat and its lipotoxic effects, disposing them to chronic kidney disease (CKD) in type 2 diabetes (T2D). We investigated whether the kidney parenchyma fat content and kidney sinus fat volume would be higher in persons with T2D and CKD. Methods: Cross-sectional study including 29 controls, 27 persons with T2D and no CKD, and 48 persons with T2D and early CKD (urine albumin creatinine ratio (UACR) ≥ 30 mg/g). Kidney parenchyma fat content and kidney sinus fat volume were assessed using magnetic resonance spectroscopy and Dixon scans respectively. Results: In the control, T2D without CKD and T2D with CKD groups, respectively, median [1st – 3rd quartile] UACR was 5 [4 – 6], 6 [5 – 10] and 95 [43 – 278] mg/g. and mean ± standard deviation estimated glomerular filtration rate was 89 ± 11, 94 ± 11 and 77 ± 22 ml/min/1.73m2. Kidney parenchyma fat content was, respectively, 1.0 [0.5–2.4], 0.7 [0.2–1.2], 1.0 [0.3–2.0] % (p = 0.26). Kidney sinus fat volume was 2.8 [1.6–7.6], 8.0 [4.7–11.3], 10.3 [5.7–14.0] ml (p < 0.01). Around 90 % of T2D participants received a sodium-glucose cotransporter-2 inhibitor or glucagon-like peptide-1 receptor agonist. Conclusions: In a setting of modern, multifactorial T2D management, kidney parenchyma fat content, evaluated with magnetic resonance spectroscopy, was similar among healthy controls and persons with T2D irrespective of CKD status. Still, kidney sinus fat volume was higher in the presence of T2D and higher still with CKD.
AB - Background and hypothesis: The kidneys may be susceptible to ectopic fat and its lipotoxic effects, disposing them to chronic kidney disease (CKD) in type 2 diabetes (T2D). We investigated whether the kidney parenchyma fat content and kidney sinus fat volume would be higher in persons with T2D and CKD. Methods: Cross-sectional study including 29 controls, 27 persons with T2D and no CKD, and 48 persons with T2D and early CKD (urine albumin creatinine ratio (UACR) ≥ 30 mg/g). Kidney parenchyma fat content and kidney sinus fat volume were assessed using magnetic resonance spectroscopy and Dixon scans respectively. Results: In the control, T2D without CKD and T2D with CKD groups, respectively, median [1st – 3rd quartile] UACR was 5 [4 – 6], 6 [5 – 10] and 95 [43 – 278] mg/g. and mean ± standard deviation estimated glomerular filtration rate was 89 ± 11, 94 ± 11 and 77 ± 22 ml/min/1.73m2. Kidney parenchyma fat content was, respectively, 1.0 [0.5–2.4], 0.7 [0.2–1.2], 1.0 [0.3–2.0] % (p = 0.26). Kidney sinus fat volume was 2.8 [1.6–7.6], 8.0 [4.7–11.3], 10.3 [5.7–14.0] ml (p < 0.01). Around 90 % of T2D participants received a sodium-glucose cotransporter-2 inhibitor or glucagon-like peptide-1 receptor agonist. Conclusions: In a setting of modern, multifactorial T2D management, kidney parenchyma fat content, evaluated with magnetic resonance spectroscopy, was similar among healthy controls and persons with T2D irrespective of CKD status. Still, kidney sinus fat volume was higher in the presence of T2D and higher still with CKD.
KW - Chronic kidney disease
KW - Ectopic kidney fat
KW - Magnetic resonance imaging
KW - Type 2 diabetes
U2 - 10.1016/j.jdiacomp.2024.108923
DO - 10.1016/j.jdiacomp.2024.108923
M3 - Journal article
C2 - 39647261
AN - SCOPUS:85211019471
VL - 39
JO - Journal of Diabetes and its Complications
JF - Journal of Diabetes and its Complications
SN - 1056-8727
IS - 2
M1 - 108923
ER -