@article{b64ecf60a6d411df928f000ea68e967b,
title = "Kinetics and template nucleation of self-assembled hydroxyapatite nanocrystallites by chondroitin sulfate",
abstract = "Biomineralization is an important process, which is often assisted by biomolecules. In this paper, the effect of chondroitin sulfate on the crystallization of hydroxyapatite was examined quantitatively based on a generic heterogeneous nucleation model. It is found that chondroitin sulfate can suppress the supersaturation-driven interfacial structure mismatch between the hydroxyapatite crystal and the substrate and promote the formation of ordered hydroxyapatite nanocrystallite assemblies. The nucleation mechanism of self-aligned hydroxyapatite nanocrystallites was examined from the viewpoints of kinetics and interfacial structure and properties, which contributes to an understanding of the fundamentals of biomineralization of self-assembled structures. The results obtained from this study will provide a basic principle to design and fabricate highly orderly organic-inorganic hybrid materials.",
author = "Huaidong Jiang and Xiang-Yang Liu and Gang Zhang and Yang Li",
note = "Keywords: Biocompatible Materials; Chondroitin Sulfates; Crystallization; Durapatite; Kinetics; Microscopy, Electron; Nanotechnology",
year = "2005",
doi = "10.1074/jbc.M412280200",
language = "English",
volume = "280",
pages = "42061--6",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology, Inc.",
number = "51",
}