Lack of aggregation of ischemic stroke subtypes within affected sibling pairs

P G Wiklund; W M Brown; T G Brott; B Stegmayr; R D Brown; S Nilsson-Ardnor; J A Hardy; B M Kissela; A Singleton; D Holmberg; S S Rich; J F Meschia

doi:10.1212/01.wnl.0000252955.17126.6a

Lack of aggregation of ischemic stroke subtypes within affected sibling pairs

P G Wiklund, W M Brown, T G Brott, B Stegmayr, R D Brown, S Nilsson-Ardnor, J A Hardy, B M Kissela, A Singleton, D Holmberg, S S Rich, J F Meschia

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

21 Citationer (Scopus)

Abstract

Udgivelsesdato: 2007-Feb-6

Originalsprog	Engelsk
Tidsskrift	Neurology
Vol/bind	68
Udgave nummer	6
Sider (fra-til)	427-31
Antal sider	4
ISSN	0028-3878
DOI	https://doi.org/10.1212/01.wnl.0000252955.17126.6a
Status	Udgivet - 2007
Udgivet eksternt	Ja

Bibliografisk note

Keywords: Adult; Aged; Brain Ischemia; Cluster Analysis; Cohort Studies; Female; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Prevalence; Risk Assessment; Risk Factors; Siblings; Stroke; Sweden; Switzerland

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Citationsformater

@article{9c22e3b0220411df8ed1000ea68e967b,

title = "Lack of aggregation of ischemic stroke subtypes within affected sibling pairs",

abstract = "OBJECTIVE: To establish whether subtypes of ischemic stroke aggregate within ischemic stroke-affected sibling pairs more than expected by chance alone. METHODS: This retrospective family study was based on a pooled analysis of two cohorts of male and female adult sibling pairs with symptomatic ischemic stroke. One hospital-based cohort of 404 individuals (first proband seen August 30, 1999) was recruited from the United States and Canada, and another population-based cohort of 198 individuals (first proband seen April 17, 1997) was recruited from Ume{\aa}, Sweden. Subtype diagnoses were based on Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria. RESULTS: Agreement for subtype diagnoses within families was poor (mean +/- asymptotic SE kappa = 0.17 +/- 0.04). Occurrence of one ischemic stroke subtype in a proband was not associated with a greater likelihood of that subtype being the qualifying stroke subtype in the sibling. Comparable levels of agreement were seen when restricting the analysis to same-sex sibling pairs (kappa = 0.22 +/- 0.05) to sibling pairs in which the proband's stroke occurred before the age of 65 years (kappa = 0.16 +/- 0.05) or to pairs in which the proband's stroke occurred at or after the age of 65 years (kappa = 0.19 +/- 0.05). CONCLUSIONS: The subtype of ischemic stroke in a proband was a poor determinant of the subtype of ischemic stroke in the respective sibling. This suggests that many genetic risk factors for ischemic stroke may not be specific for one subtype.",

author = "Wiklund, {P G} and Brown, {W M} and Brott, {T G} and B Stegmayr and Brown, {R D} and S Nilsson-Ardnor and Hardy, {J A} and Kissela, {B M} and A Singleton and D Holmberg and Rich, {S S} and Meschia, {J F}",

note = "Keywords: Adult; Aged; Brain Ischemia; Cluster Analysis; Cohort Studies; Female; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Prevalence; Risk Assessment; Risk Factors; Siblings; Stroke; Sweden; Switzerland",

year = "2007",

doi = "10.1212/01.wnl.0000252955.17126.6a",

language = "English",

volume = "68",

pages = "427--31",

journal = "Neurology",

issn = "0028-3878",

publisher = "Lippincott Williams & Wilkins",

number = "6",

}

TY - JOUR

T1 - Lack of aggregation of ischemic stroke subtypes within affected sibling pairs

AU - Wiklund, P G

AU - Brown, W M

AU - Brott, T G

AU - Stegmayr, B

AU - Brown, R D

AU - Nilsson-Ardnor, S

AU - Hardy, J A

AU - Kissela, B M

AU - Singleton, A

AU - Holmberg, D

AU - Rich, S S

AU - Meschia, J F

N1 - Keywords: Adult; Aged; Brain Ischemia; Cluster Analysis; Cohort Studies; Female; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Prevalence; Risk Assessment; Risk Factors; Siblings; Stroke; Sweden; Switzerland

PY - 2007

Y1 - 2007

N2 - OBJECTIVE: To establish whether subtypes of ischemic stroke aggregate within ischemic stroke-affected sibling pairs more than expected by chance alone. METHODS: This retrospective family study was based on a pooled analysis of two cohorts of male and female adult sibling pairs with symptomatic ischemic stroke. One hospital-based cohort of 404 individuals (first proband seen August 30, 1999) was recruited from the United States and Canada, and another population-based cohort of 198 individuals (first proband seen April 17, 1997) was recruited from Umeå, Sweden. Subtype diagnoses were based on Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria. RESULTS: Agreement for subtype diagnoses within families was poor (mean +/- asymptotic SE kappa = 0.17 +/- 0.04). Occurrence of one ischemic stroke subtype in a proband was not associated with a greater likelihood of that subtype being the qualifying stroke subtype in the sibling. Comparable levels of agreement were seen when restricting the analysis to same-sex sibling pairs (kappa = 0.22 +/- 0.05) to sibling pairs in which the proband's stroke occurred before the age of 65 years (kappa = 0.16 +/- 0.05) or to pairs in which the proband's stroke occurred at or after the age of 65 years (kappa = 0.19 +/- 0.05). CONCLUSIONS: The subtype of ischemic stroke in a proband was a poor determinant of the subtype of ischemic stroke in the respective sibling. This suggests that many genetic risk factors for ischemic stroke may not be specific for one subtype.

AB - OBJECTIVE: To establish whether subtypes of ischemic stroke aggregate within ischemic stroke-affected sibling pairs more than expected by chance alone. METHODS: This retrospective family study was based on a pooled analysis of two cohorts of male and female adult sibling pairs with symptomatic ischemic stroke. One hospital-based cohort of 404 individuals (first proband seen August 30, 1999) was recruited from the United States and Canada, and another population-based cohort of 198 individuals (first proband seen April 17, 1997) was recruited from Umeå, Sweden. Subtype diagnoses were based on Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria. RESULTS: Agreement for subtype diagnoses within families was poor (mean +/- asymptotic SE kappa = 0.17 +/- 0.04). Occurrence of one ischemic stroke subtype in a proband was not associated with a greater likelihood of that subtype being the qualifying stroke subtype in the sibling. Comparable levels of agreement were seen when restricting the analysis to same-sex sibling pairs (kappa = 0.22 +/- 0.05) to sibling pairs in which the proband's stroke occurred before the age of 65 years (kappa = 0.16 +/- 0.05) or to pairs in which the proband's stroke occurred at or after the age of 65 years (kappa = 0.19 +/- 0.05). CONCLUSIONS: The subtype of ischemic stroke in a proband was a poor determinant of the subtype of ischemic stroke in the respective sibling. This suggests that many genetic risk factors for ischemic stroke may not be specific for one subtype.

U2 - 10.1212/01.wnl.0000252955.17126.6a

DO - 10.1212/01.wnl.0000252955.17126.6a

M3 - Journal article

C2 - 17283317

SN - 0028-3878

VL - 68

SP - 427

EP - 431

JO - Neurology

JF - Neurology

IS - 6

ER -