Late sensory function after intraoperative capsaicin wound instillation

E K Aasvang; J B Hansen; H Kehlet; E K Aasvang; J B Hansen; H Kehlet

doi:10.1111/j.1399-6576.2009.02068.x

Late sensory function after intraoperative capsaicin wound instillation

E K Aasvang, J B Hansen, H Kehlet, E K Aasvang, J B Hansen, H Kehlet

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

15 Citationer (Scopus)

Abstract

Udgivelsesdato: 2010-Feb

Originalsprog	Engelsk
Tidsskrift	Acta Anaesthesiologica Scandinavica
Vol/bind	54
Udgave nummer	2
Sider (fra-til)	224-31
Antal sider	8
ISSN	0001-5172
DOI	https://doi.org/10.1111/j.1399-6576.2009.02068.x https://doi.org/10.1111/j.1399-6576.2009.02068.x
Status	Udgivet - 1 feb. 2010

Bibliografisk note

Keywords: Adolescent; Adult; Aged; Analgesics; Capsaicin; Double-Blind Method; Follow-Up Studies; Hernia, Inguinal; Humans; Hyperalgesia; Instillation, Drug; Intraoperative Care; Male; Middle Aged; Nerve Fibers; Pain Measurement; Pain Threshold; Pain, Postoperative; Placebos; Pressure; Sensation; Sensory System Agents; Sensory Thresholds; Surgical Mesh; Temperature Sense; Touch; Treatment Outcome; Young Adult

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Citationsformater

@article{df02a8b0582211df928f000ea68e967b,

title = "Late sensory function after intraoperative capsaicin wound instillation",

abstract = "BACKGROUND: Intense capsaicin-induced C-fiber stimulation results in reversible lysis of the nerve soma, thereby making capsaicin wound instillation of potential interest for the treatment of post-operative pain. Clinical histological and short-term sensory studies suggest that the C-fiber function is partly re-established after skin injection of capsaicin. However, no study has evaluated the long-term effects of wound instillation of purified capsaicin on sensory functions. METHODS: Patients included in a double-blind placebo-controlled randomized study of the analgesic effect of capsaicin after groin hernia repair were examined by quantitative sensory testing before, 1 week and 2 years post-operatively. The primary endpoint was occurrence of hyperalgesia/allodynia. The secondary endpoints were acute and late sensory changes between the two patient groups. Patients were blinded to the allocated treatment. RESULTS: Twenty (100%) capsaicin and 16 (76%) placebo-treated patients were seen at the 2 1/2 year follow-up. Hyperalgesia was seen in five capsaicin- vs. one placebo-treated patient (P=0.2). The mechanical detection threshold was significantly increased on the operated side in the capsaicin vs. placebo group at the 1-week follow-up (P<0.05), but was not different at the 2 1/2 year follow-up (P=0.3). There were no other significant differences in sensory function on the operated side between groups at the pre-operative, 1-week or 2 1/2 year post-operative follow-up (P>0.05). The sensory function on the contralateral side was comparable between groups throughout the study (P>0.1). CONCLUSION: This small-volume study calls for further long-term safety studies of wound capsaicin instillation.",

author = "Aasvang, {E K} and Hansen, {J B} and H Kehlet and Aasvang, {E K} and Hansen, {J B} and H Kehlet",

note = "Keywords: Adolescent; Adult; Aged; Analgesics; Capsaicin; Double-Blind Method; Follow-Up Studies; Hernia, Inguinal; Humans; Hyperalgesia; Instillation, Drug; Intraoperative Care; Male; Middle Aged; Nerve Fibers; Pain Measurement; Pain Threshold; Pain, Postoperative; Placebos; Pressure; Sensation; Sensory System Agents; Sensory Thresholds; Surgical Mesh; Temperature Sense; Touch; Treatment Outcome; Young Adult",

year = "2010",

month = feb,

day = "1",

doi = "10.1111/j.1399-6576.2009.02068.x",

language = "English",

volume = "54",

pages = "224--31",

journal = "Acta Anaesthesiologica Scandinavica",

issn = "0001-5172",

publisher = "Wiley-Blackwell",

number = "2",

}

TY - JOUR

T1 - Late sensory function after intraoperative capsaicin wound instillation

AU - Aasvang, E K

AU - Hansen, J B

AU - Kehlet, H

AU - Aasvang, E K

AU - Hansen, J B

AU - Kehlet, H

N1 - Keywords: Adolescent; Adult; Aged; Analgesics; Capsaicin; Double-Blind Method; Follow-Up Studies; Hernia, Inguinal; Humans; Hyperalgesia; Instillation, Drug; Intraoperative Care; Male; Middle Aged; Nerve Fibers; Pain Measurement; Pain Threshold; Pain, Postoperative; Placebos; Pressure; Sensation; Sensory System Agents; Sensory Thresholds; Surgical Mesh; Temperature Sense; Touch; Treatment Outcome; Young Adult

PY - 2010/2/1

Y1 - 2010/2/1

N2 - BACKGROUND: Intense capsaicin-induced C-fiber stimulation results in reversible lysis of the nerve soma, thereby making capsaicin wound instillation of potential interest for the treatment of post-operative pain. Clinical histological and short-term sensory studies suggest that the C-fiber function is partly re-established after skin injection of capsaicin. However, no study has evaluated the long-term effects of wound instillation of purified capsaicin on sensory functions. METHODS: Patients included in a double-blind placebo-controlled randomized study of the analgesic effect of capsaicin after groin hernia repair were examined by quantitative sensory testing before, 1 week and 2 years post-operatively. The primary endpoint was occurrence of hyperalgesia/allodynia. The secondary endpoints were acute and late sensory changes between the two patient groups. Patients were blinded to the allocated treatment. RESULTS: Twenty (100%) capsaicin and 16 (76%) placebo-treated patients were seen at the 2 1/2 year follow-up. Hyperalgesia was seen in five capsaicin- vs. one placebo-treated patient (P=0.2). The mechanical detection threshold was significantly increased on the operated side in the capsaicin vs. placebo group at the 1-week follow-up (P<0.05), but was not different at the 2 1/2 year follow-up (P=0.3). There were no other significant differences in sensory function on the operated side between groups at the pre-operative, 1-week or 2 1/2 year post-operative follow-up (P>0.05). The sensory function on the contralateral side was comparable between groups throughout the study (P>0.1). CONCLUSION: This small-volume study calls for further long-term safety studies of wound capsaicin instillation.

AB - BACKGROUND: Intense capsaicin-induced C-fiber stimulation results in reversible lysis of the nerve soma, thereby making capsaicin wound instillation of potential interest for the treatment of post-operative pain. Clinical histological and short-term sensory studies suggest that the C-fiber function is partly re-established after skin injection of capsaicin. However, no study has evaluated the long-term effects of wound instillation of purified capsaicin on sensory functions. METHODS: Patients included in a double-blind placebo-controlled randomized study of the analgesic effect of capsaicin after groin hernia repair were examined by quantitative sensory testing before, 1 week and 2 years post-operatively. The primary endpoint was occurrence of hyperalgesia/allodynia. The secondary endpoints were acute and late sensory changes between the two patient groups. Patients were blinded to the allocated treatment. RESULTS: Twenty (100%) capsaicin and 16 (76%) placebo-treated patients were seen at the 2 1/2 year follow-up. Hyperalgesia was seen in five capsaicin- vs. one placebo-treated patient (P=0.2). The mechanical detection threshold was significantly increased on the operated side in the capsaicin vs. placebo group at the 1-week follow-up (P<0.05), but was not different at the 2 1/2 year follow-up (P=0.3). There were no other significant differences in sensory function on the operated side between groups at the pre-operative, 1-week or 2 1/2 year post-operative follow-up (P>0.05). The sensory function on the contralateral side was comparable between groups throughout the study (P>0.1). CONCLUSION: This small-volume study calls for further long-term safety studies of wound capsaicin instillation.

U2 - 10.1111/j.1399-6576.2009.02068.x

DO - 10.1111/j.1399-6576.2009.02068.x

M3 - Journal article

C2 - 19681784

SN - 0001-5172

VL - 54

SP - 224

EP - 231

JO - Acta Anaesthesiologica Scandinavica

JF - Acta Anaesthesiologica Scandinavica

IS - 2

ER -