Long-term exposure to air pollution and mortality in a Danish nationwide administrative cohort study: Beyond mortality from cardiopulmonary disease and lung cancer

Rina So, Zorana J Andersen, Jie Chen, Massimo Stafoggia, Kees de Hoogh, Klea Katsouyanni, Danielle Vienneau, Sophia Rodopoulou, Evangelia Samoli, Youn-Hee Lim, Jeanette T Jørgensen, Heresh Amini, Tom Cole-Hunter, Seyed Mahmood Taghavi Shahri, Matija Maric, Marie Bergmann, Shuo Liu, Shadi Azam, Steffen Loft, Rudi G J WestendorpLaust H Mortensen, Mariska Bauwelinck, Jochem O Klompmaker, Richard Atkinson, Nicole A H Janssen, Bente Oftedal, Matteo Renzi, Francesco Forastiere, Maciek Strak, Lau C Thygesen, Bert Brunekreef, Gerard Hoek, Amar J Mehta

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Abstract

BACKGROUND: The association between long-term exposure to air pollution and mortality from cardiorespiratory diseases is well established, yet the evidence for other diseases remains limited.

OBJECTIVES: To examine the associations of long-term exposure to air pollution with mortality from diabetes, dementia, psychiatric disorders, chronic kidney disease (CKD), asthma, acute lower respiratory infection (ALRI), as well as mortality from all-natural and cardiorespiratory causes in the Danish nationwide administrative cohort.

METHODS: We followed all residents aged ≥ 30 years (3,083,227) in Denmark from 1 January 2000 until 31 December 2017. Annual mean concentrations of fine particulate matter (PM 2.5), nitrogen dioxide (NO 2), black carbon (BC), and ozone (warm season) were estimated using European-wide hybrid land-use regression models (100 m × 100 m) and assigned to baseline residential addresses. We used Cox proportional hazard models to evaluate the association between air pollution and mortality, accounting for demographic and socioeconomic factors. We additionally applied indirect adjustment for smoking and body mass index (BMI).

RESULTS: During 47,023,454 person-years of follow-up, 803,881 people died from natural causes. Long-term exposure to PM 2.5 (mean: 12.4 µg/m 3), NO 2 (20.3 µg/m 3), and/or BC (1.0 × 10 -5/m) was statistically significantly associated with all studied mortality outcomes except CKD. A 5 µg/m 3 increase in PM 2.5 was associated with higher mortality from all-natural causes (hazard ratio 1.11; 95% confidence interval 1.09-1.13), cardiovascular disease (1.09; 1.07-1.12), respiratory disease (1.11; 1.07-1.15), lung cancer (1.19; 1.15-1.24), diabetes (1.10; 1.04-1.16), dementia (1.05; 1.00-1.10), psychiatric disorders (1.38; 1.27-1.50), asthma (1.13; 0.94-1.36), and ALRI (1.14; 1.09-1.20). Associations with long-term exposure to ozone (mean: 80.2 µg/m 3) were generally negative but became significantly positive for several endpoints in two-pollutant models. Generally, associations were attenuated but remained significant after indirect adjustment for smoking and BMI.

CONCLUSION: Long-term exposure to PM 2.5, NO 2, and/or BC in Denmark were associated with mortality beyond cardiorespiratory diseases, including diabetes, dementia, psychiatric disorders, asthma, and ALRI.

OriginalsprogEngelsk
Artikelnummer107241
TidsskriftEnvironment International
Vol/bind164
ISSN0160-4120
DOI
StatusUdgivet - 2022

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