Long-term exposure to ambient air pollution and road traffic noise and asthma incidence in adults: The Danish Nurse cohort

Shuo Liu; Youn-Hee Lim; Marie Pedersen; Jeanette T Jørgensen; Heresh Amini; Thomas Cole-Hunter; Amar J Mehta; Rina So; Laust H Mortensen; Rudi G J Westendorp; Steffen Loft; Elvira V Bräuner; Matthias Ketzel; Ole Hertel; Jørgen Brandt; Steen S Jensen; Jesper H Christensen; Torben Sigsgaard; Camilla Geels; Lise M Frohn; Maja Brborić; Jelena Radonić; Maja Turk Sekulic; Klaus Bønnelykke; Claus Backalarz; Mette K. Simonsen; Zorana J Andersen

doi:10.1016/j.envint.2021.106464

Long-term exposure to ambient air pollution and road traffic noise and asthma incidence in adults: The Danish Nurse cohort

Shuo Liu, Youn-Hee Lim, Marie Pedersen, Jeanette T Jørgensen, Heresh Amini, Thomas Cole-Hunter, Amar J Mehta, Rina So, Laust H Mortensen, Rudi G J Westendorp, Steffen Loft, Elvira V Bräuner, Matthias Ketzel, Ole Hertel, Jørgen Brandt, Steen S Jensen, Jesper H Christensen, Torben Sigsgaard, Camilla Geels, Lise M FrohnMaja Brborić, Jelena Radonić, Maja Turk Sekulic, Klaus Bønnelykke, Claus Backalarz, Mette K. Simonsen, Zorana J Andersen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

28 Citationer (Scopus)

88 Downloads (Pure)

Abstract

BACKGROUND: Ambient air pollution is likely a risk factor for asthma, and recent evidence suggests the possible relevance of road traffic noise.

OBJECTIVES: We examined the associations of long-term exposure to air pollution and road traffic noise with adult-asthma incidence.

METHODS: We followed 28,731 female nurses (age > 44 years) from the Danish Nurse Cohort, recruited in 1993 and 1999, for first hospital contact for asthma from 1977 until 2015. We estimated residential annual mean concentrations of particulate matter with diameter < 2.5 µm (PM2.5) since 1990 and nitrogen dioxide (NO2) since 1970 with the Danish DEHM/UBM/AirGIS modeling system, and road traffic noise (Lden) since 1970 with the Nord2000 model. Time-varying Cox regression models were used to associate air pollution and road traffic noise exposure with asthma incidence.

RESULTS: During 18.6 years' mean follow-up, 528 out of 23,093 participants had hospital contact for asthma. The hazard ratios (HR) and 95% confidence intervals for asthma incidence associated with 3-year moving average exposures were 1.29 (1.03, 1.61) per 6.3 µg/m3 for PM2.5, 1.16 (1.07, 1.27) per 8.2 µg/m3 for NO2, and 1.12 (1.00, 1.25) per 10 dB for Lden. The HR for NO2 remained unchanged after adjustment for either PM2.5 or Lden, while the HRs for PM2.5 and Lden attenuated to unity after adjustment for NO2.

CONCLUSIONS: Long-term exposure to air pollution was associated with adult-asthma incidence independently of road traffic noise, with NO2 most relevant. Road traffic noise was not independently associated with adult-asthma incidence.

Originalsprog	Engelsk
Artikelnummer	106464
Tidsskrift	Environment International
Vol/bind	152
ISSN	0160-4120
DOI	https://doi.org/10.1016/j.envint.2021.106464
Status	Udgivet - 2021

Bibliografisk note

Adgang til dokumentet

10.1016/j.envint.2021.106464Licens: CC BY

Long-term exposure to ambient air pollution and road traffic noise and asthma incidence in adultsForlagets udgivne version, 2,6 MBLicens: CC BY

Citationsformater

Liu, S., Lim, Y-H., Pedersen, M., Jørgensen, J. T., Amini, H., Cole-Hunter, T., Mehta, A. J., So, R., Mortensen, L. H., Westendorp, R. G. J., Loft, S., Bräuner, E. V., Ketzel, M., Hertel, O., Brandt, J., Jensen, S. S., Christensen, J. H., Sigsgaard, T., Geels, C., ... Andersen, Z. J. (2021). Long-term exposure to ambient air pollution and road traffic noise and asthma incidence in adults: The Danish Nurse cohort. Environment International, 152, [106464]. https://doi.org/10.1016/j.envint.2021.106464

Long-term exposure to ambient air pollution and road traffic noise and asthma incidence in adults : The Danish Nurse cohort. / Liu, Shuo; Lim, Youn-Hee ; Pedersen, Marie; Jørgensen, Jeanette T; Amini, Heresh; Cole-Hunter, Thomas; Mehta, Amar J; So, Rina ; Mortensen, Laust H ; Westendorp, Rudi G J ; Loft, Steffen; Bräuner, Elvira V; Ketzel, Matthias; Hertel, Ole; Brandt, Jørgen; Jensen, Steen S; Christensen, Jesper H; Sigsgaard, Torben; Geels, Camilla; Frohn, Lise M; Brborić, Maja; Radonić, Jelena; Sekulic, Maja Turk; Bønnelykke, Klaus; Backalarz, Claus; Simonsen, Mette K.; Andersen, Zorana J.

I: Environment International, Bind 152, 106464, 2021.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Liu, S, Lim, Y-H , Pedersen, M, Jørgensen, JT, Amini, H, Cole-Hunter, T, Mehta, AJ, So, R , Mortensen, LH , Westendorp, RGJ , Loft, S, Bräuner, EV, Ketzel, M, Hertel, O, Brandt, J, Jensen, SS, Christensen, JH, Sigsgaard, T, Geels, C, Frohn, LM, Brborić, M, Radonić, J, Sekulic, MT, Bønnelykke, K, Backalarz, C, Simonsen, MK & Andersen, ZJ 2021, 'Long-term exposure to ambient air pollution and road traffic noise and asthma incidence in adults: The Danish Nurse cohort', Environment International, bind 152, 106464. https://doi.org/10.1016/j.envint.2021.106464

Liu, Shuo ; Lim, Youn-Hee ; Pedersen, Marie ; Jørgensen, Jeanette T ; Amini, Heresh ; Cole-Hunter, Thomas ; Mehta, Amar J ; So, Rina ; Mortensen, Laust H ; Westendorp, Rudi G J ; Loft, Steffen ; Bräuner, Elvira V ; Ketzel, Matthias ; Hertel, Ole ; Brandt, Jørgen ; Jensen, Steen S ; Christensen, Jesper H ; Sigsgaard, Torben ; Geels, Camilla ; Frohn, Lise M ; Brborić, Maja ; Radonić, Jelena ; Sekulic, Maja Turk ; Bønnelykke, Klaus ; Backalarz, Claus ; Simonsen, Mette K. ; Andersen, Zorana J. / Long-term exposure to ambient air pollution and road traffic noise and asthma incidence in adults : The Danish Nurse cohort. I: Environment International. 2021 ; Bind 152.

@article{a5e47c270c364c3b87845c940802c8c6,

title = "Long-term exposure to ambient air pollution and road traffic noise and asthma incidence in adults: The Danish Nurse cohort",

abstract = "BACKGROUND: Ambient air pollution is likely a risk factor for asthma, and recent evidence suggests the possible relevance of road traffic noise.OBJECTIVES: We examined the associations of long-term exposure to air pollution and road traffic noise with adult-asthma incidence.METHODS: We followed 28,731 female nurses (age > 44 years) from the Danish Nurse Cohort, recruited in 1993 and 1999, for first hospital contact for asthma from 1977 until 2015. We estimated residential annual mean concentrations of particulate matter with diameter < 2.5 µm (PM2.5) since 1990 and nitrogen dioxide (NO2) since 1970 with the Danish DEHM/UBM/AirGIS modeling system, and road traffic noise (Lden) since 1970 with the Nord2000 model. Time-varying Cox regression models were used to associate air pollution and road traffic noise exposure with asthma incidence.RESULTS: During 18.6 years' mean follow-up, 528 out of 23,093 participants had hospital contact for asthma. The hazard ratios (HR) and 95% confidence intervals for asthma incidence associated with 3-year moving average exposures were 1.29 (1.03, 1.61) per 6.3 µg/m3 for PM2.5, 1.16 (1.07, 1.27) per 8.2 µg/m3 for NO2, and 1.12 (1.00, 1.25) per 10 dB for Lden. The HR for NO2 remained unchanged after adjustment for either PM2.5 or Lden, while the HRs for PM2.5 and Lden attenuated to unity after adjustment for NO2.CONCLUSIONS: Long-term exposure to air pollution was associated with adult-asthma incidence independently of road traffic noise, with NO2 most relevant. Road traffic noise was not independently associated with adult-asthma incidence.",

author = "Shuo Liu and Youn-Hee Lim and Marie Pedersen and J{\o}rgensen, {Jeanette T} and Heresh Amini and Thomas Cole-Hunter and Mehta, {Amar J} and Rina So and Mortensen, {Laust H} and Westendorp, {Rudi G J} and Steffen Loft and Br{\"a}uner, {Elvira V} and Matthias Ketzel and Ole Hertel and J{\o}rgen Brandt and Jensen, {Steen S} and Christensen, {Jesper H} and Torben Sigsgaard and Camilla Geels and Frohn, {Lise M} and Maja Brbori{\'c} and Jelena Radoni{\'c} and Sekulic, {Maja Turk} and Klaus B{\o}nnelykke and Claus Backalarz and Simonsen, {Mette K.} and Andersen, {Zorana J}",

note = "Copyright {\textcopyright} 2021. Published by Elsevier Ltd.",

year = "2021",

doi = "10.1016/j.envint.2021.106464",

language = "English",

volume = "152",

journal = "Environment international",

issn = "0160-4120",

publisher = "Pergamon Press",

}

TY - JOUR

T1 - Long-term exposure to ambient air pollution and road traffic noise and asthma incidence in adults

T2 - The Danish Nurse cohort

AU - Liu, Shuo

AU - Lim, Youn-Hee

AU - Pedersen, Marie

AU - Jørgensen, Jeanette T

AU - Amini, Heresh

AU - Cole-Hunter, Thomas

AU - Mehta, Amar J

AU - So, Rina

AU - Mortensen, Laust H

AU - Westendorp, Rudi G J

AU - Loft, Steffen

AU - Bräuner, Elvira V

AU - Ketzel, Matthias

AU - Hertel, Ole

AU - Brandt, Jørgen

AU - Jensen, Steen S

AU - Christensen, Jesper H

AU - Sigsgaard, Torben

AU - Geels, Camilla

AU - Frohn, Lise M

AU - Brborić, Maja

AU - Radonić, Jelena

AU - Sekulic, Maja Turk

AU - Bønnelykke, Klaus

AU - Backalarz, Claus

AU - Simonsen, Mette K.

AU - Andersen, Zorana J

PY - 2021

Y1 - 2021

N2 - BACKGROUND: Ambient air pollution is likely a risk factor for asthma, and recent evidence suggests the possible relevance of road traffic noise.OBJECTIVES: We examined the associations of long-term exposure to air pollution and road traffic noise with adult-asthma incidence.METHODS: We followed 28,731 female nurses (age > 44 years) from the Danish Nurse Cohort, recruited in 1993 and 1999, for first hospital contact for asthma from 1977 until 2015. We estimated residential annual mean concentrations of particulate matter with diameter < 2.5 µm (PM2.5) since 1990 and nitrogen dioxide (NO2) since 1970 with the Danish DEHM/UBM/AirGIS modeling system, and road traffic noise (Lden) since 1970 with the Nord2000 model. Time-varying Cox regression models were used to associate air pollution and road traffic noise exposure with asthma incidence.RESULTS: During 18.6 years' mean follow-up, 528 out of 23,093 participants had hospital contact for asthma. The hazard ratios (HR) and 95% confidence intervals for asthma incidence associated with 3-year moving average exposures were 1.29 (1.03, 1.61) per 6.3 µg/m3 for PM2.5, 1.16 (1.07, 1.27) per 8.2 µg/m3 for NO2, and 1.12 (1.00, 1.25) per 10 dB for Lden. The HR for NO2 remained unchanged after adjustment for either PM2.5 or Lden, while the HRs for PM2.5 and Lden attenuated to unity after adjustment for NO2.CONCLUSIONS: Long-term exposure to air pollution was associated with adult-asthma incidence independently of road traffic noise, with NO2 most relevant. Road traffic noise was not independently associated with adult-asthma incidence.

AB - BACKGROUND: Ambient air pollution is likely a risk factor for asthma, and recent evidence suggests the possible relevance of road traffic noise.OBJECTIVES: We examined the associations of long-term exposure to air pollution and road traffic noise with adult-asthma incidence.METHODS: We followed 28,731 female nurses (age > 44 years) from the Danish Nurse Cohort, recruited in 1993 and 1999, for first hospital contact for asthma from 1977 until 2015. We estimated residential annual mean concentrations of particulate matter with diameter < 2.5 µm (PM2.5) since 1990 and nitrogen dioxide (NO2) since 1970 with the Danish DEHM/UBM/AirGIS modeling system, and road traffic noise (Lden) since 1970 with the Nord2000 model. Time-varying Cox regression models were used to associate air pollution and road traffic noise exposure with asthma incidence.RESULTS: During 18.6 years' mean follow-up, 528 out of 23,093 participants had hospital contact for asthma. The hazard ratios (HR) and 95% confidence intervals for asthma incidence associated with 3-year moving average exposures were 1.29 (1.03, 1.61) per 6.3 µg/m3 for PM2.5, 1.16 (1.07, 1.27) per 8.2 µg/m3 for NO2, and 1.12 (1.00, 1.25) per 10 dB for Lden. The HR for NO2 remained unchanged after adjustment for either PM2.5 or Lden, while the HRs for PM2.5 and Lden attenuated to unity after adjustment for NO2.CONCLUSIONS: Long-term exposure to air pollution was associated with adult-asthma incidence independently of road traffic noise, with NO2 most relevant. Road traffic noise was not independently associated with adult-asthma incidence.

U2 - 10.1016/j.envint.2021.106464

DO - 10.1016/j.envint.2021.106464

M3 - Journal article

C2 - 33684733

VL - 152

JO - Environment international

JF - Environment international

SN - 0160-4120

M1 - 106464

ER -