TY - JOUR
T1 - Long-term exposure to traffic noise and risk of incident colon cancer
T2 - A pooled study of eleven Nordic cohorts
AU - Roswall, Nina
AU - Thacher, Jesse D
AU - Ögren, Mikael
AU - Pyko, Andrei
AU - Åkesson, Agneta
AU - Oudin, Anna
AU - Tjønneland, Anne
AU - Rosengren, Annika
AU - Poulsen, Aslak H
AU - Eriksson, Charlotta
AU - Segersson, David
AU - Rizzuto, Debora
AU - Helte, Emilie
AU - Andersson, Eva M
AU - Aasvang, Gunn Marit
AU - Gudjonsdottir, Hrafnhildur
AU - Khan, Jibran
AU - Selander, Jenny
AU - Christensen, Jesper H
AU - Brandt, Jørgen
AU - Leander, Karin
AU - Mattisson, Kristoffer
AU - Eneroth, Kristina
AU - Stucki, Lara
AU - Barregard, Lars
AU - Stockfelt, Leo
AU - Albin, Maria
AU - Simonsen, Mette K
AU - Spanne, Mårten
AU - Jousilahti, Pekka
AU - Tiittanen, Pekka
AU - Molnàr, Peter
AU - Ljungman, Petter L S
AU - Yli-Tuomi, Tarja
AU - Cole-Hunter, Thomas
AU - Lanki, Timo
AU - Hvidtfeldt, Ulla A
AU - Lim, Youn-Hee
AU - Andersen, Zorana J
AU - Pershagen, Göran
AU - Sørensen, Mette
N1 - Copyright © 2023. Published by Elsevier Inc.
PY - 2023
Y1 - 2023
N2 - Background Colon cancer incidence is rising globally, and factors pertaining to urbanization have been proposed involved in this development. Traffic noise may increase colon cancer risk by causing sleep disturbance and stress, thereby inducing known colon cancer risk-factors, e.g. obesity, diabetes, physical inactivity, and alcohol consumption, but few studies have examined this. Objectives The objective of this study was to investigate the association between traffic noise and colon cancer (all, proximal, distal) in a pooled population of 11 Nordic cohorts, totaling 155,203 persons. Methods We identified residential address history and estimated road, railway, and aircraft noise, as well as air pollution, for all addresses, using similar exposure models across cohorts. Colon cancer cases were identified through national registries. We analyzed data using Cox Proportional Hazards Models, adjusting main models for harmonized sociodemographic and lifestyle data. Results During follow-up (median 18.8 years), 2757 colon cancer cases developed. We found a hazard ratio (HR) of 1.05 (95% confidence interval (CI): 0.99-1.10) per 10-dB higher 5-year mean time-weighted road traffic noise. In sub-type analyses, the association seemed confined to distal colon cancer: HR 1.06 (95% CI: 0.98-1.14). Railway and aircraft noise was not associated with colon cancer, albeit there was some indication in sub-type analyses that railway noise may also be associated with distal colon cancer. In interaction-analyses, the association between road traffic noise and colon cancer was strongest among obese persons and those with high NO
2-exposure. Discussion A prominent study strength is the large population with harmonized data across eleven cohorts, and the complete address-history during follow-up. However, each cohort estimated noise independently, and only at the most exposed façade, which may introduce exposure misclassification. Despite this, the results of this pooled study suggest that traffic noise may be a risk factor for colon cancer, especially of distal origin.
AB - Background Colon cancer incidence is rising globally, and factors pertaining to urbanization have been proposed involved in this development. Traffic noise may increase colon cancer risk by causing sleep disturbance and stress, thereby inducing known colon cancer risk-factors, e.g. obesity, diabetes, physical inactivity, and alcohol consumption, but few studies have examined this. Objectives The objective of this study was to investigate the association between traffic noise and colon cancer (all, proximal, distal) in a pooled population of 11 Nordic cohorts, totaling 155,203 persons. Methods We identified residential address history and estimated road, railway, and aircraft noise, as well as air pollution, for all addresses, using similar exposure models across cohorts. Colon cancer cases were identified through national registries. We analyzed data using Cox Proportional Hazards Models, adjusting main models for harmonized sociodemographic and lifestyle data. Results During follow-up (median 18.8 years), 2757 colon cancer cases developed. We found a hazard ratio (HR) of 1.05 (95% confidence interval (CI): 0.99-1.10) per 10-dB higher 5-year mean time-weighted road traffic noise. In sub-type analyses, the association seemed confined to distal colon cancer: HR 1.06 (95% CI: 0.98-1.14). Railway and aircraft noise was not associated with colon cancer, albeit there was some indication in sub-type analyses that railway noise may also be associated with distal colon cancer. In interaction-analyses, the association between road traffic noise and colon cancer was strongest among obese persons and those with high NO
2-exposure. Discussion A prominent study strength is the large population with harmonized data across eleven cohorts, and the complete address-history during follow-up. However, each cohort estimated noise independently, and only at the most exposed façade, which may introduce exposure misclassification. Despite this, the results of this pooled study suggest that traffic noise may be a risk factor for colon cancer, especially of distal origin.
U2 - 10.1016/j.envres.2023.115454
DO - 10.1016/j.envres.2023.115454
M3 - Journal article
C2 - 36764429
VL - 224
JO - Environmental Research
JF - Environmental Research
SN - 0013-9351
M1 - 115454
ER -