TY - JOUR
T1 - Long-Term Exposure to Transportation Noise and Ischemic Heart Disease
T2 - A Pooled Analysis of Nine Scandinavian Cohorts
AU - Pyko, Andrei
AU - Roswall, Nina
AU - Ögren, Mikael
AU - Oudin, Anna
AU - Rosengren, Annika
AU - Eriksson, Charlotta
AU - Segersson, David
AU - Rizzuto, Debora
AU - Andersson, Eva M
AU - Aasvang, Gunn Marit
AU - Engström, Gunnar
AU - Gudjonsdottir, Hrafnhildur
AU - Jørgensen, Jeanette T
AU - Selander, Jenny
AU - Christensen, Jesper H
AU - Brandt, Jørgen
AU - Leander, Karin
AU - Overvad, Kim
AU - Eneroth, Kristina
AU - Mattisson, Kristoffer
AU - Barregard, Lars
AU - Stockfelt, Leo
AU - Albin, Maria
AU - Simonsen, Mette K
AU - Tiittanen, Pekka
AU - Molnar, Peter
AU - Ljungman, Petter
AU - Solvang Jensen, Steen
AU - Gustafsson, Susanna
AU - Lanki, Timo
AU - Lim, Youn-Hee
AU - Andersen, Zorana J
AU - Sørensen, Mette
AU - Pershagen, Göran
PY - 2023
Y1 - 2023
N2 - BACKGROUND: Transportation noise may induce cardiovascular disease, but the public health implications are unclear.OBJECTIVES: The study aimed to assess exposure-response relationships for different transportation noise sources and ischemic heart disease (IHD), including subtypes.METHODS: Pooled analyses were performed of nine cohorts from Denmark and Sweden, together including 132,801 subjects. Time-weighted long-term exposure to road, railway, and aircraft noise, as well as air pollution, was estimated based on residential histories. Hazard ratios (HRs) were calculated using Cox proportional hazards models following adjustment for lifestyle and socioeconomic risk factors.RESULTS: A total of 22,459 incident cases of IHD were identified during follow-up from national patient and mortality registers, including 7,682 cases of myocardial infarction. The adjusted HR for IHD was 1.03 [95% confidence interval (CI) 1.00, 1.05] per 10 dB
L
den
for both road and railway noise exposure during 5 y prior to the event. Higher risks were indicated for IHD excluding angina pectoris cases, with HRs of 1.06 (95% CI: 1.03, 1.08) and 1.05 (95% CI: 1.01, 1.08) per 10 dB
L
den
for road and railway noise, respectively. Corresponding HRs for myocardial infarction were 1.02 (95% CI: 0.99, 1.05) and 1.04 (95% CI: 0.99, 1.08). Increased risks were observed for aircraft noise but without clear exposure-response relations. A threshold at around 55 dB
L
den
was suggested in the exposure-response relation for road traffic noise and IHD.
DISCUSSION: Exposure to road, railway, and aircraft noise in the prior 5 y was associated with an increased risk of IHD, particularly after exclusion of angina pectoris cases, which are less well identified in the registries. https://doi.org/10.1289/EHP10745.
AB - BACKGROUND: Transportation noise may induce cardiovascular disease, but the public health implications are unclear.OBJECTIVES: The study aimed to assess exposure-response relationships for different transportation noise sources and ischemic heart disease (IHD), including subtypes.METHODS: Pooled analyses were performed of nine cohorts from Denmark and Sweden, together including 132,801 subjects. Time-weighted long-term exposure to road, railway, and aircraft noise, as well as air pollution, was estimated based on residential histories. Hazard ratios (HRs) were calculated using Cox proportional hazards models following adjustment for lifestyle and socioeconomic risk factors.RESULTS: A total of 22,459 incident cases of IHD were identified during follow-up from national patient and mortality registers, including 7,682 cases of myocardial infarction. The adjusted HR for IHD was 1.03 [95% confidence interval (CI) 1.00, 1.05] per 10 dB
L
den
for both road and railway noise exposure during 5 y prior to the event. Higher risks were indicated for IHD excluding angina pectoris cases, with HRs of 1.06 (95% CI: 1.03, 1.08) and 1.05 (95% CI: 1.01, 1.08) per 10 dB
L
den
for road and railway noise, respectively. Corresponding HRs for myocardial infarction were 1.02 (95% CI: 0.99, 1.05) and 1.04 (95% CI: 0.99, 1.08). Increased risks were observed for aircraft noise but without clear exposure-response relations. A threshold at around 55 dB
L
den
was suggested in the exposure-response relation for road traffic noise and IHD.
DISCUSSION: Exposure to road, railway, and aircraft noise in the prior 5 y was associated with an increased risk of IHD, particularly after exclusion of angina pectoris cases, which are less well identified in the registries. https://doi.org/10.1289/EHP10745.
KW - Humans
KW - Noise, Transportation/adverse effects
KW - Environmental Exposure
KW - Myocardial Ischemia/epidemiology
KW - Myocardial Infarction/epidemiology
KW - Angina Pectoris
U2 - 10.1289/EHP10745
DO - 10.1289/EHP10745
M3 - Journal article
C2 - 36607286
VL - 131
JO - Environmental Health Perspectives
JF - Environmental Health Perspectives
SN - 0091-6765
IS - 1
M1 - 17003
ER -