Long-term hormone replacement therapy preserves bone mineral density in Turner syndrome

Line Cleemann; Britta E Hjerrild; Anna L Lauridsen; Lene Heickendorff; Jens S Christiansen; Leif Mosekilde; Claus H Gravholt

doi:10.1530/EJE-09-0020

Long-term hormone replacement therapy preserves bone mineral density in Turner syndrome

Line Cleemann, Britta E Hjerrild, Anna L Lauridsen, Lene Heickendorff, Jens S Christiansen, Leif Mosekilde, Claus H Gravholt

Institut for Klinisk Medicin

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

59 Citationer (Scopus)

Abstract

Udgivelsesdato: 2009-Aug

Originalsprog	Engelsk
Tidsskrift	European Journal of Endocrinology
Vol/bind	161
Udgave nummer	2
Sider (fra-til)	251-7
Antal sider	6
ISSN	0804-4643
DOI	https://doi.org/10.1530/EJE-09-0020
Status	Udgivet - 2009

Bibliografisk note

Keywords: Absorptiometry, Photon; Adult; Aged; Bone Density; Bone and Bones; Calcium; Estrogen Replacement Therapy; Estrogens; Exercise; Female; Heart Rate; Humans; Longitudinal Studies; Middle Aged; Prospective Studies; Turner Syndrome; Vitamin D; Young Adult

Adgang til dokumentet

10.1530/EJE-09-0020

Citationsformater

@article{2ca4b9274fba4a4988c627a65c243095,

title = "Long-term hormone replacement therapy preserves bone mineral density in Turner syndrome",

abstract = "CONTEXT: Reduced bone mineral density (BMD) and increased risk of fractures are present in many women with Turner syndrome (TS). OBJECTIVE: Examine longitudinal changes in BMD in TS and relate changes to biochemical parameters. DESIGN: Prospective, pragmatic, and observational study. Examinations at baseline and follow-up (5.9+/-0.7 years). SETTING: Tertiary hospital. PARTICIPANTS: Fifty-four women with TS (43.0+/-9.95 years). Interventions Hormone replacement therapy (HRT) and calcium and vitamin D supplementation. Main outcome measures BMD (g/cm(2)) measured at lumbar spine, hip, and the non-dominant forearm. Bone formation and resorption markers, sex hormones, IGF1, and maximal oxygen uptake. RESULTS: At follow-up, forearm BMD, radius ultradistal BMD, and hip BMD remained unchanged, radius 1/3 BMD declined (0.601+/-0.059 vs 0.592+/-0.059, P=0.03), while spine BMD increased (0.972+/-0.139 vs 1.010+/-0.144, P<0.0005). Bone formation markers did not change over time in TS. Bone resorption markers decreased over time in TS. Testosterone, IGF1, and maximal oxygen uptake was significantly reduced in TS. CONCLUSION: Longitudinal changes in BMD in TS were slight. BMD can be maintained at most sites in well-informed women with TS, being encouraged to maintain a healthy lifestyle, including HRT and intake of calcium and vitamin D.",

author = "Line Cleemann and Hjerrild, {Britta E} and Lauridsen, {Anna L} and Lene Heickendorff and Christiansen, {Jens S} and Leif Mosekilde and Gravholt, {Claus H}",

note = "Keywords: Absorptiometry, Photon; Adult; Aged; Bone Density; Bone and Bones; Calcium; Estrogen Replacement Therapy; Estrogens; Exercise; Female; Heart Rate; Humans; Longitudinal Studies; Middle Aged; Prospective Studies; Turner Syndrome; Vitamin D; Young Adult",

year = "2009",

doi = "10.1530/EJE-09-0020",

language = "English",

volume = "161",

pages = "251--7",

journal = "European Journal of Endocrinology",

issn = "0804-4643",

publisher = "BioScientifica Ltd.",

number = "2",

}

TY - JOUR

T1 - Long-term hormone replacement therapy preserves bone mineral density in Turner syndrome

AU - Cleemann, Line

AU - Hjerrild, Britta E

AU - Lauridsen, Anna L

AU - Heickendorff, Lene

AU - Christiansen, Jens S

AU - Mosekilde, Leif

AU - Gravholt, Claus H

N1 - Keywords: Absorptiometry, Photon; Adult; Aged; Bone Density; Bone and Bones; Calcium; Estrogen Replacement Therapy; Estrogens; Exercise; Female; Heart Rate; Humans; Longitudinal Studies; Middle Aged; Prospective Studies; Turner Syndrome; Vitamin D; Young Adult

PY - 2009

Y1 - 2009

N2 - CONTEXT: Reduced bone mineral density (BMD) and increased risk of fractures are present in many women with Turner syndrome (TS). OBJECTIVE: Examine longitudinal changes in BMD in TS and relate changes to biochemical parameters. DESIGN: Prospective, pragmatic, and observational study. Examinations at baseline and follow-up (5.9+/-0.7 years). SETTING: Tertiary hospital. PARTICIPANTS: Fifty-four women with TS (43.0+/-9.95 years). Interventions Hormone replacement therapy (HRT) and calcium and vitamin D supplementation. Main outcome measures BMD (g/cm(2)) measured at lumbar spine, hip, and the non-dominant forearm. Bone formation and resorption markers, sex hormones, IGF1, and maximal oxygen uptake. RESULTS: At follow-up, forearm BMD, radius ultradistal BMD, and hip BMD remained unchanged, radius 1/3 BMD declined (0.601+/-0.059 vs 0.592+/-0.059, P=0.03), while spine BMD increased (0.972+/-0.139 vs 1.010+/-0.144, P<0.0005). Bone formation markers did not change over time in TS. Bone resorption markers decreased over time in TS. Testosterone, IGF1, and maximal oxygen uptake was significantly reduced in TS. CONCLUSION: Longitudinal changes in BMD in TS were slight. BMD can be maintained at most sites in well-informed women with TS, being encouraged to maintain a healthy lifestyle, including HRT and intake of calcium and vitamin D.

AB - CONTEXT: Reduced bone mineral density (BMD) and increased risk of fractures are present in many women with Turner syndrome (TS). OBJECTIVE: Examine longitudinal changes in BMD in TS and relate changes to biochemical parameters. DESIGN: Prospective, pragmatic, and observational study. Examinations at baseline and follow-up (5.9+/-0.7 years). SETTING: Tertiary hospital. PARTICIPANTS: Fifty-four women with TS (43.0+/-9.95 years). Interventions Hormone replacement therapy (HRT) and calcium and vitamin D supplementation. Main outcome measures BMD (g/cm(2)) measured at lumbar spine, hip, and the non-dominant forearm. Bone formation and resorption markers, sex hormones, IGF1, and maximal oxygen uptake. RESULTS: At follow-up, forearm BMD, radius ultradistal BMD, and hip BMD remained unchanged, radius 1/3 BMD declined (0.601+/-0.059 vs 0.592+/-0.059, P=0.03), while spine BMD increased (0.972+/-0.139 vs 1.010+/-0.144, P<0.0005). Bone formation markers did not change over time in TS. Bone resorption markers decreased over time in TS. Testosterone, IGF1, and maximal oxygen uptake was significantly reduced in TS. CONCLUSION: Longitudinal changes in BMD in TS were slight. BMD can be maintained at most sites in well-informed women with TS, being encouraged to maintain a healthy lifestyle, including HRT and intake of calcium and vitamin D.

U2 - 10.1530/EJE-09-0020

DO - 10.1530/EJE-09-0020

M3 - Journal article

SN - 0804-4643

VL - 161

SP - 251

EP - 257

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

IS - 2

ER -