Long-term survival in patients hospitalized with congestive heart failure: relation to preserved and reduced left ventricular systolic function

Finn Gustafsson; Christian Torp-Pedersen; Bente Brendorp; Marie Seibaek; Hans Burchardt; Lars Køber; DIAMOND Study Group

Long-term survival in patients hospitalized with congestive heart failure: relation to preserved and reduced left ventricular systolic function

Finn Gustafsson, Christian Torp-Pedersen, Bente Brendorp, Marie Seibaek, Hans Burchardt, Lars Køber, DIAMOND Study Group

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

140 Citationer (Scopus)

Abstract

Udgivelsesdato: 2003-May

Originalsprog	Engelsk
Tidsskrift	European Heart Journal
Vol/bind	24
Udgave nummer	9
Sider (fra-til)	863-70
Antal sider	7
ISSN	0195-668X
Status	Udgivet - 2003

Bibliografisk note

Keywords: Aged; Cohort Studies; Confidence Intervals; Female; Heart Failure; Hospital Mortality; Hospitalization; Humans; Male; Prognosis; Survival Analysis; Ventricular Dysfunction, Left

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Citationsformater

@article{2c7f4250118e11df803f000ea68e967b,

title = "Long-term survival in patients hospitalized with congestive heart failure: relation to preserved and reduced left ventricular systolic function",

abstract = "AIMS: The purpose of this study was to evaluate the influence of left ventricular systolic function on the survival in a large consecutive cohort of patients hospitalized with congestive heart failure and to determine how left ventricular systolic function interacts with co-morbid conditions in terms of prognosis. METHODS AND RESULTS: Analysis of survival data from 5491 patients admitted for new or worsening heart failure to 34 departments of cardiology or internal medicine in Denmark from 1993-1996 was carried out. A standardized echocardiogram was available for 95% of the patients, and left ventricular systolic function was estimated using wall motion index score. Follow-up time was 5-8 years. Patients with preserved systolic function were older, more frequently female, and had less evidence of ischemia than patients with systolic dysfunction. After 1 year, 24% of the patients had died. Low wall motion index was a potent independent predictor of death (risk ratio for one unit increase, 0.60 (0.56-0.64)), and was of greater prognostic significance in younger patients and patients with a history of myocardial ischemia. However, even in patients with preserved systolic function, mortality was high (1 year mortality, 19%). CONCLUSION: In hospitalized heart failure patients, particularly in younger patients with ischemic heart disease, mortality risk is inversely related to left ventricular systolic function.",

author = "Finn Gustafsson and Christian Torp-Pedersen and Bente Brendorp and Marie Seibaek and Hans Burchardt and Lars K{\o}ber and {DIAMOND Study Group}",

note = "Keywords: Aged; Cohort Studies; Confidence Intervals; Female; Heart Failure; Hospital Mortality; Hospitalization; Humans; Male; Prognosis; Survival Analysis; Ventricular Dysfunction, Left",

year = "2003",

language = "English",

volume = "24",

pages = "863--70",

journal = "European Heart Journal",

issn = "0195-668X",

publisher = "Oxford University Press",

number = "9",

}

TY - JOUR

T1 - Long-term survival in patients hospitalized with congestive heart failure: relation to preserved and reduced left ventricular systolic function

AU - Gustafsson, Finn

AU - Torp-Pedersen, Christian

AU - Brendorp, Bente

AU - Seibaek, Marie

AU - Burchardt, Hans

AU - Køber, Lars

AU - DIAMOND Study Group

N1 - Keywords: Aged; Cohort Studies; Confidence Intervals; Female; Heart Failure; Hospital Mortality; Hospitalization; Humans; Male; Prognosis; Survival Analysis; Ventricular Dysfunction, Left

PY - 2003

Y1 - 2003

N2 - AIMS: The purpose of this study was to evaluate the influence of left ventricular systolic function on the survival in a large consecutive cohort of patients hospitalized with congestive heart failure and to determine how left ventricular systolic function interacts with co-morbid conditions in terms of prognosis. METHODS AND RESULTS: Analysis of survival data from 5491 patients admitted for new or worsening heart failure to 34 departments of cardiology or internal medicine in Denmark from 1993-1996 was carried out. A standardized echocardiogram was available for 95% of the patients, and left ventricular systolic function was estimated using wall motion index score. Follow-up time was 5-8 years. Patients with preserved systolic function were older, more frequently female, and had less evidence of ischemia than patients with systolic dysfunction. After 1 year, 24% of the patients had died. Low wall motion index was a potent independent predictor of death (risk ratio for one unit increase, 0.60 (0.56-0.64)), and was of greater prognostic significance in younger patients and patients with a history of myocardial ischemia. However, even in patients with preserved systolic function, mortality was high (1 year mortality, 19%). CONCLUSION: In hospitalized heart failure patients, particularly in younger patients with ischemic heart disease, mortality risk is inversely related to left ventricular systolic function.

AB - AIMS: The purpose of this study was to evaluate the influence of left ventricular systolic function on the survival in a large consecutive cohort of patients hospitalized with congestive heart failure and to determine how left ventricular systolic function interacts with co-morbid conditions in terms of prognosis. METHODS AND RESULTS: Analysis of survival data from 5491 patients admitted for new or worsening heart failure to 34 departments of cardiology or internal medicine in Denmark from 1993-1996 was carried out. A standardized echocardiogram was available for 95% of the patients, and left ventricular systolic function was estimated using wall motion index score. Follow-up time was 5-8 years. Patients with preserved systolic function were older, more frequently female, and had less evidence of ischemia than patients with systolic dysfunction. After 1 year, 24% of the patients had died. Low wall motion index was a potent independent predictor of death (risk ratio for one unit increase, 0.60 (0.56-0.64)), and was of greater prognostic significance in younger patients and patients with a history of myocardial ischemia. However, even in patients with preserved systolic function, mortality was high (1 year mortality, 19%). CONCLUSION: In hospitalized heart failure patients, particularly in younger patients with ischemic heart disease, mortality risk is inversely related to left ventricular systolic function.

M3 - Journal article

C2 - 12727154

SN - 0195-668X

VL - 24

SP - 863

EP - 870

JO - European Heart Journal

JF - European Heart Journal

IS - 9

ER -