Abstract
S-nitrosylation of proteins is a nitric oxide (NO)-based post-translational modification of cysteine residues. By removing the NO moiety from S-nitrosothiol adducts, denitrosylases restore sulfhydryl protein pool and act as downstream tuners of S-nitrosylation signaling. Alterations in the S-nitrosylation/denitrosylation dynamics are implicated in many pathological states, including cancer ontogenesis and progression, skeletal muscle myogenesis and function. Here, we aim to provide and link different lines of evidence, and elaborate on the possible role of S-nitrosylation/denitrosylation signaling in rhabdomyosarcoma, one of the most common pediatric mesenchymal malignancy.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Nitric Oxide - Biology and Chemistry |
| Vol/bind | 122-123 |
| Sider (fra-til) | 1-5 |
| Antal sider | 5 |
| ISSN | 1089-8603 |
| DOI | |
| Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:This work has been supported by grants from Novo Nordisk Foundation ( 2018–0052550 to G.F.); Associazione Italiana per la Ricerca sul Cancro ( AIRC , IG2017-20719 to G.F.); Danish Cancer Society Grant ( KBVU R146-A9414 ; R231-A13855 to G.F.). The laboratory in Copenhagen is part of the Center of Excellence in Autophagy, Recycling and Disease (CARD), funded by the Danish National Research Foundation ( #DNRF125 ). C.M. is supported by the Fondazione Umberto Veronesi .
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© 2022