Loop electrosurgical excision of the cervix and risk for spontaneous preterm delivery in twin pregnancies

Bugge Noehr; Allan Jensen; Kirsten Frederiksen; Ann Tabor; Susanne K Kjaer

doi:10.1097/AOG.0b013e3181b1377b

Loop electrosurgical excision of the cervix and risk for spontaneous preterm delivery in twin pregnancies

Bugge Noehr, Allan Jensen, Kirsten Frederiksen, Ann Tabor, Susanne K Kjaer

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

19 Citationer (Scopus)

Abstract

Udgivelsesdato: 2009-Sep

Originalsprog	Engelsk
Tidsskrift	Obstetrics and Gynecology
Vol/bind	114
Udgave nummer	3
Sider (fra-til)	511-5
Antal sider	4
ISSN	0029-7844
DOI	https://doi.org/10.1097/AOG.0b013e3181b1377b
Status	Udgivet - 2009

Bibliografisk note

Keywords: Ablation Techniques; Adolescent; Adult; Cervical Intraepithelial Neoplasia; Cohort Studies; Conization; Electrosurgery; Female; Humans; Pregnancy; Pregnancy Complications, Neoplastic; Pregnancy, Multiple; Premature Birth; Retrospective Studies; Risk Factors; Twins; Uterine Cervical Neoplasms; Young Adult

Adgang til dokumentet

10.1097/AOG.0b013e3181b1377b

Citationsformater

@article{a56606e0680011df928f000ea68e967b,

title = "Loop electrosurgical excision of the cervix and risk for spontaneous preterm delivery in twin pregnancies",

abstract = "OBJECTIVE: To investigate the association between three cervical procedures (biopsy with no treatment, ablation, and loop electrosurgical excision procedure [LEEP]) and subsequent spontaneous preterm delivery in twin pregnancies using population-based data from various nationwide registries. METHODS:: The study population consisted of all twin deliveries in Denmark during a 9-year period, 1997-2005. Information on the deliveries, including cervical procedures, was obtained from various national registries. In all, 9,868 deliveries were eligible for analyses, of which 3,228 were delivered spontaneously preterm (32.7%). Preterm delivery was defined as gestational age between 21 weeks and 37 weeks. Logistic regression analyses were used to evaluate the association between cervical procedures and preterm delivery. RESULTS: Twin pregnancies subsequent to LEEP had a significantly increased risk of overall subsequent spontaneous preterm delivery (43.4%) with an adjusted odds ratio of 1.58 (95% confidence interval 1.16-2.14) compared with pregnancies with no prior LEEP (32.5%). The association was consistent in various secondary analyses and especially strong for the very preterm and extremely preterm groups. We found no increase in risk of preterm delivery subsequent to biopsy without treatment or ablation. CONCLUSION: Our study showed an overall significant increase in risk of preterm delivery in twin pregnancies subsequent to LEEP treatment, even after adjustment for several potential risk factors. LEVEL OF EVIDENCE: II.",

author = "Bugge Noehr and Allan Jensen and Kirsten Frederiksen and Ann Tabor and Kjaer, {Susanne K}",

note = "Keywords: Ablation Techniques; Adolescent; Adult; Cervical Intraepithelial Neoplasia; Cohort Studies; Conization; Electrosurgery; Female; Humans; Pregnancy; Pregnancy Complications, Neoplastic; Pregnancy, Multiple; Premature Birth; Retrospective Studies; Risk Factors; Twins; Uterine Cervical Neoplasms; Young Adult",

year = "2009",

doi = "10.1097/AOG.0b013e3181b1377b",

language = "English",

volume = "114",

pages = "511--5",

journal = "Obstetrics and Gynecology",

issn = "0029-7844",

publisher = "Lippincott Williams & Wilkins",

number = "3",

}

TY - JOUR

T1 - Loop electrosurgical excision of the cervix and risk for spontaneous preterm delivery in twin pregnancies

AU - Noehr, Bugge

AU - Jensen, Allan

AU - Frederiksen, Kirsten

AU - Tabor, Ann

AU - Kjaer, Susanne K

N1 - Keywords: Ablation Techniques; Adolescent; Adult; Cervical Intraepithelial Neoplasia; Cohort Studies; Conization; Electrosurgery; Female; Humans; Pregnancy; Pregnancy Complications, Neoplastic; Pregnancy, Multiple; Premature Birth; Retrospective Studies; Risk Factors; Twins; Uterine Cervical Neoplasms; Young Adult

PY - 2009

Y1 - 2009

N2 - OBJECTIVE: To investigate the association between three cervical procedures (biopsy with no treatment, ablation, and loop electrosurgical excision procedure [LEEP]) and subsequent spontaneous preterm delivery in twin pregnancies using population-based data from various nationwide registries. METHODS:: The study population consisted of all twin deliveries in Denmark during a 9-year period, 1997-2005. Information on the deliveries, including cervical procedures, was obtained from various national registries. In all, 9,868 deliveries were eligible for analyses, of which 3,228 were delivered spontaneously preterm (32.7%). Preterm delivery was defined as gestational age between 21 weeks and 37 weeks. Logistic regression analyses were used to evaluate the association between cervical procedures and preterm delivery. RESULTS: Twin pregnancies subsequent to LEEP had a significantly increased risk of overall subsequent spontaneous preterm delivery (43.4%) with an adjusted odds ratio of 1.58 (95% confidence interval 1.16-2.14) compared with pregnancies with no prior LEEP (32.5%). The association was consistent in various secondary analyses and especially strong for the very preterm and extremely preterm groups. We found no increase in risk of preterm delivery subsequent to biopsy without treatment or ablation. CONCLUSION: Our study showed an overall significant increase in risk of preterm delivery in twin pregnancies subsequent to LEEP treatment, even after adjustment for several potential risk factors. LEVEL OF EVIDENCE: II.

AB - OBJECTIVE: To investigate the association between three cervical procedures (biopsy with no treatment, ablation, and loop electrosurgical excision procedure [LEEP]) and subsequent spontaneous preterm delivery in twin pregnancies using population-based data from various nationwide registries. METHODS:: The study population consisted of all twin deliveries in Denmark during a 9-year period, 1997-2005. Information on the deliveries, including cervical procedures, was obtained from various national registries. In all, 9,868 deliveries were eligible for analyses, of which 3,228 were delivered spontaneously preterm (32.7%). Preterm delivery was defined as gestational age between 21 weeks and 37 weeks. Logistic regression analyses were used to evaluate the association between cervical procedures and preterm delivery. RESULTS: Twin pregnancies subsequent to LEEP had a significantly increased risk of overall subsequent spontaneous preterm delivery (43.4%) with an adjusted odds ratio of 1.58 (95% confidence interval 1.16-2.14) compared with pregnancies with no prior LEEP (32.5%). The association was consistent in various secondary analyses and especially strong for the very preterm and extremely preterm groups. We found no increase in risk of preterm delivery subsequent to biopsy without treatment or ablation. CONCLUSION: Our study showed an overall significant increase in risk of preterm delivery in twin pregnancies subsequent to LEEP treatment, even after adjustment for several potential risk factors. LEVEL OF EVIDENCE: II.

U2 - 10.1097/AOG.0b013e3181b1377b

DO - 10.1097/AOG.0b013e3181b1377b

M3 - Journal article

C2 - 19701028

SN - 0029-7844

VL - 114

SP - 511

EP - 515

JO - Obstetrics and Gynecology

JF - Obstetrics and Gynecology

IS - 3

ER -