Loss of Function Studies in Mice and Genetic Association Link Receptor Protein Tyrosine Phosphatase a to Schizophrenia

Nagahide Takahashi; Karin Sandager Nielsen; Branko Aleksic; Steffen Petersen; Masashi Ikeda; Itaru Kushima; Nathalie Vacaresse; Hiroshi Ujike; Nakao Iwata; Véronique Dubreuil; Naheed Mirza; Takeshi Sakurai; Norio Ozaki; Joseph D Buxbaum; Jan Sap

doi:10.1016/j.biopsych.2011.06.016

Loss of Function Studies in Mice and Genetic Association Link Receptor Protein Tyrosine Phosphatase a to Schizophrenia

Nagahide Takahashi, Karin Sandager Nielsen, Branko Aleksic, Steffen Petersen, Masashi Ikeda, Itaru Kushima, Nathalie Vacaresse, Hiroshi Ujike, Nakao Iwata, Véronique Dubreuil, Naheed Mirza, Takeshi Sakurai, Norio Ozaki, Joseph D Buxbaum, Jan Sap

Biomedicinsk Institut

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

21 Citationer (Scopus)

Abstract

Solid evidence links schizophrenia (SZ) susceptibility to neurodevelopmental processes involving tyrosine phosphorylation-mediated signaling. Mouse studies implicate the Ptpra gene, encoding protein tyrosine phosphatase RPTPa, in the control of radial neuronal migration, cortical cytoarchitecture, and oligodendrocyte differentiation. The human gene encoding RPTPa, PTPRA, maps to a chromosomal region (20p13) associated with susceptibility to psychotic illness.

Originalsprog	Engelsk
Tidsskrift	Biological Psychiatry
Vol/bind	70
Udgave nummer	7
Sider (fra-til)	626-35
Antal sider	10
ISSN	0006-3223
DOI	https://doi.org/10.1016/j.biopsych.2011.06.016
Status	Udgivet - 1 okt. 2011

Adgang til dokumentet

10.1016/j.biopsych.2011.06.016

Citationsformater

Takahashi, N., Nielsen, K. S., Aleksic, B., Petersen, S., Ikeda, M., Kushima, I., Vacaresse, N., Ujike, H., Iwata, N., Dubreuil, V., Mirza, N., Sakurai, T., Ozaki, N., Buxbaum, J. D., & Sap, J. (2011). Loss of Function Studies in Mice and Genetic Association Link Receptor Protein Tyrosine Phosphatase a to Schizophrenia. Biological Psychiatry, 70(7), 626-35. https://doi.org/10.1016/j.biopsych.2011.06.016

Takahashi, N, Nielsen, KS, Aleksic, B, Petersen, S, Ikeda, M, Kushima, I, Vacaresse, N, Ujike, H, Iwata, N, Dubreuil, V, Mirza, N, Sakurai, T, Ozaki, N, Buxbaum, JD & Sap, J 2011, 'Loss of Function Studies in Mice and Genetic Association Link Receptor Protein Tyrosine Phosphatase a to Schizophrenia', Biological Psychiatry, bind 70, nr. 7, s. 626-35. https://doi.org/10.1016/j.biopsych.2011.06.016

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abstract = "Solid evidence links schizophrenia (SZ) susceptibility to neurodevelopmental processes involving tyrosine phosphorylation-mediated signaling. Mouse studies implicate the Ptpra gene, encoding protein tyrosine phosphatase RPTPa, in the control of radial neuronal migration, cortical cytoarchitecture, and oligodendrocyte differentiation. The human gene encoding RPTPa, PTPRA, maps to a chromosomal region (20p13) associated with susceptibility to psychotic illness.",

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T1 - Loss of Function Studies in Mice and Genetic Association Link Receptor Protein Tyrosine Phosphatase a to Schizophrenia

AU - Takahashi, Nagahide

AU - Nielsen, Karin Sandager

AU - Aleksic, Branko

AU - Petersen, Steffen

AU - Ikeda, Masashi

AU - Kushima, Itaru

AU - Vacaresse, Nathalie

AU - Ujike, Hiroshi

AU - Iwata, Nakao

AU - Dubreuil, Véronique

AU - Mirza, Naheed

AU - Sakurai, Takeshi

AU - Ozaki, Norio

AU - Buxbaum, Joseph D

AU - Sap, Jan

PY - 2011/10/1

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N2 - Solid evidence links schizophrenia (SZ) susceptibility to neurodevelopmental processes involving tyrosine phosphorylation-mediated signaling. Mouse studies implicate the Ptpra gene, encoding protein tyrosine phosphatase RPTPa, in the control of radial neuronal migration, cortical cytoarchitecture, and oligodendrocyte differentiation. The human gene encoding RPTPa, PTPRA, maps to a chromosomal region (20p13) associated with susceptibility to psychotic illness.

AB - Solid evidence links schizophrenia (SZ) susceptibility to neurodevelopmental processes involving tyrosine phosphorylation-mediated signaling. Mouse studies implicate the Ptpra gene, encoding protein tyrosine phosphatase RPTPa, in the control of radial neuronal migration, cortical cytoarchitecture, and oligodendrocyte differentiation. The human gene encoding RPTPa, PTPRA, maps to a chromosomal region (20p13) associated with susceptibility to psychotic illness.

U2 - 10.1016/j.biopsych.2011.06.016

DO - 10.1016/j.biopsych.2011.06.016

M3 - Journal article

C2 - 21831360

SN - 0006-3223

VL - 70

SP - 626

EP - 635

JO - Biological Psychiatry

JF - Biological Psychiatry

IS - 7

ER -