Loss of K+ currents in heart failure is accentuated in KChIP2 deficient mice

Søren Jahn Grubb, Tobias Speerschneider, Dona Occhipinti, Céline Fiset, Søren-Peter Olesen, Morten Bækgaard Thomsen, Kirstine Callø

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19 Citationer (Scopus)

Abstract

KV 4 together with KV Channel-Interacting Protein 2 (KChIP2) mediate the fast recovering transient outward potassium current (Ito,f ) in the heart. KChIP2 is downregulated in human heart failure (HF), potentially underlying the loss of Ito,f . We investigated remodeling associated with HF hypothesizing that KChIP2 plays a central role in the modulation of outward K(+) currents in HF.
OriginalsprogEngelsk
TidsskriftJournal of Cardiovascular Electrophysiology
Vol/bind25
Udgave nummer8
Sider (fra-til)896-904
Antal sider9
DOI
StatusUdgivet - 2014

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