Loss of K+ currents in heart failure is accentuated in KChIP2 deficient mice

Søren Jahn Grubb; Tobias Speerschneider; Dona Occhipinti; Céline Fiset; Søren-Peter Olesen; Morten Bækgaard Thomsen; Kirstine Callø

doi:10.1111/jce.12422

Loss of K⁺ currents in heart failure is accentuated in KChIP2 deficient mice

Søren Jahn Grubb, Tobias Speerschneider, Dona Occhipinti, Céline Fiset, Søren-Peter Olesen, Morten Bækgaard Thomsen, Kirstine Callø

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

19 Citationer (Scopus)

Abstract

KV 4 together with KV Channel-Interacting Protein 2 (KChIP2) mediate the fast recovering transient outward potassium current (Ito,f ) in the heart. KChIP2 is downregulated in human heart failure (HF), potentially underlying the loss of Ito,f . We investigated remodeling associated with HF hypothesizing that KChIP2 plays a central role in the modulation of outward K(+) currents in HF.

Originalsprog	Engelsk
Tidsskrift	Journal of Cardiovascular Electrophysiology
Vol/bind	25
Udgave nummer	8
Sider (fra-til)	896-904
Antal sider	9
DOI	https://doi.org/10.1111/jce.12422
Status	Udgivet - 2014

Adgang til dokumentet

10.1111/jce.12422

Citationsformater

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title = "Loss of K+ currents in heart failure is accentuated in KChIP2 deficient mice",

abstract = "KV 4 together with KV Channel-Interacting Protein 2 (KChIP2) mediate the fast recovering transient outward potassium current (Ito,f ) in the heart. KChIP2 is downregulated in human heart failure (HF), potentially underlying the loss of Ito,f . We investigated remodeling associated with HF hypothesizing that KChIP2 plays a central role in the modulation of outward K(+) currents in HF.",

author = "Grubb, {S{\o}ren Jahn} and Tobias Speerschneider and Dona Occhipinti and C{\'e}line Fiset and S{\o}ren-Peter Olesen and Thomsen, {Morten B{\ae}kgaard} and Kirstine Call{\o}",

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T1 - Loss of K+ currents in heart failure is accentuated in KChIP2 deficient mice

AU - Grubb, Søren Jahn

AU - Speerschneider, Tobias

AU - Occhipinti, Dona

AU - Fiset, Céline

AU - Olesen, Søren-Peter

AU - Thomsen, Morten Bækgaard

AU - Callø, Kirstine

PY - 2014

Y1 - 2014

N2 - KV 4 together with KV Channel-Interacting Protein 2 (KChIP2) mediate the fast recovering transient outward potassium current (Ito,f ) in the heart. KChIP2 is downregulated in human heart failure (HF), potentially underlying the loss of Ito,f . We investigated remodeling associated with HF hypothesizing that KChIP2 plays a central role in the modulation of outward K(+) currents in HF.

AB - KV 4 together with KV Channel-Interacting Protein 2 (KChIP2) mediate the fast recovering transient outward potassium current (Ito,f ) in the heart. KChIP2 is downregulated in human heart failure (HF), potentially underlying the loss of Ito,f . We investigated remodeling associated with HF hypothesizing that KChIP2 plays a central role in the modulation of outward K(+) currents in HF.

U2 - 10.1111/jce.12422

DO - 10.1111/jce.12422

M3 - Journal article

C2 - 24678923

SN - 1540-8167

VL - 25

SP - 896

EP - 904

JO - Journal of Cardiovascular Electrophysiology

JF - Journal of Cardiovascular Electrophysiology

IS - 8

ER -