Low-Frequency Raman Spectroscopic Study on Compression-Induced Destabilization in Melt-Quenched Amorphous Celecoxib

Kā Rlis Bē Rziņš; Sara J. Fraser-Miller; Thomas Rades; Keith C. Gordon

doi:10.1021/acs.molpharmaceut.9b00557

Low-Frequency Raman Spectroscopic Study on Compression-Induced Destabilization in Melt-Quenched Amorphous Celecoxib

Kā Rlis Bē Rziņš
, Sara J. Fraser-Miller
, Thomas Rades
, Keith C. Gordon^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

A series of melt-quenched disks of amorphous celecoxib were obtained using two different cooling rates (>100 °C/min and ∼25-30 °C/min) and subjected to different compression pressures (125, 250, and 500 MPa) and dwell times (0, 30, and 60 s). The kinetics of crystallization for these differently prepared melt-quenched disks were probed using a number of methods. Low-frequency Raman spectroscopy was used to monitor isothermal crystallization kinetics, whereas dynamic differential scanning calorimetry served as a complimentary technique to identify changes in form. Although both compression parameters destabilized the amorphous celecoxib, the dwell time was found to have a more critical overall effect. Additionally, the sample history was affirmed to be a factor for limiting the magnitude of compression-induced destabilization.

Originalsprog	Engelsk
Tidsskrift	Molecular Pharmaceutics
Vol/bind	16
Udgave nummer	8
Sider (fra-til)	3678-3686
Antal sider	9
ISSN	1543-8384
DOI	https://doi.org/10.1021/acs.molpharmaceut.9b00557
Status	Udgivet - 2019

Finansiering

K.B. thanks the University of Otago for Ph.D. scholarship. Jonathan Barnsley is thanked for taking high-quality reference photos of the amorphous celecoxib disks. We gratefully acknowledge the contribution of New Zealand eScience Infrastructure (NeSI) high-performance computing facilities and the support from the Dodd-Walls Centre for Photonic and Quantum Technologies.

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Citationsformater

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title = "Low-Frequency Raman Spectroscopic Study on Compression-Induced Destabilization in Melt-Quenched Amorphous Celecoxib",

abstract = "A series of melt-quenched disks of amorphous celecoxib were obtained using two different cooling rates (>100 °C/min and ∼25-30 °C/min) and subjected to different compression pressures (125, 250, and 500 MPa) and dwell times (0, 30, and 60 s). The kinetics of crystallization for these differently prepared melt-quenched disks were probed using a number of methods. Low-frequency Raman spectroscopy was used to monitor isothermal crystallization kinetics, whereas dynamic differential scanning calorimetry served as a complimentary technique to identify changes in form. Although both compression parameters destabilized the amorphous celecoxib, the dwell time was found to have a more critical overall effect. Additionally, the sample history was affirmed to be a factor for limiting the magnitude of compression-induced destabilization.",

keywords = "amorphous drugs, celecoxib, compression-induced destabilization, differential scanning calorimetry, low-frequency Raman spectroscopy",

author = "\{Bē Rziņ{\v s}\}, \{Kā Rlis\} and Fraser-Miller, \{Sara J.\} and Thomas Rades and Gordon, \{Keith C.\}",

year = "2019",

doi = "10.1021/acs.molpharmaceut.9b00557",

language = "English",

volume = "16",

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journal = "Molecular Pharmaceutics",

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T1 - Low-Frequency Raman Spectroscopic Study on Compression-Induced Destabilization in Melt-Quenched Amorphous Celecoxib

AU - Bē Rziņš, Kā Rlis

AU - Fraser-Miller, Sara J.

AU - Rades, Thomas

AU - Gordon, Keith C.

PY - 2019

Y1 - 2019

N2 - A series of melt-quenched disks of amorphous celecoxib were obtained using two different cooling rates (>100 °C/min and ∼25-30 °C/min) and subjected to different compression pressures (125, 250, and 500 MPa) and dwell times (0, 30, and 60 s). The kinetics of crystallization for these differently prepared melt-quenched disks were probed using a number of methods. Low-frequency Raman spectroscopy was used to monitor isothermal crystallization kinetics, whereas dynamic differential scanning calorimetry served as a complimentary technique to identify changes in form. Although both compression parameters destabilized the amorphous celecoxib, the dwell time was found to have a more critical overall effect. Additionally, the sample history was affirmed to be a factor for limiting the magnitude of compression-induced destabilization.

AB - A series of melt-quenched disks of amorphous celecoxib were obtained using two different cooling rates (>100 °C/min and ∼25-30 °C/min) and subjected to different compression pressures (125, 250, and 500 MPa) and dwell times (0, 30, and 60 s). The kinetics of crystallization for these differently prepared melt-quenched disks were probed using a number of methods. Low-frequency Raman spectroscopy was used to monitor isothermal crystallization kinetics, whereas dynamic differential scanning calorimetry served as a complimentary technique to identify changes in form. Although both compression parameters destabilized the amorphous celecoxib, the dwell time was found to have a more critical overall effect. Additionally, the sample history was affirmed to be a factor for limiting the magnitude of compression-induced destabilization.

KW - amorphous drugs

KW - celecoxib

KW - compression-induced destabilization

KW - differential scanning calorimetry

KW - low-frequency Raman spectroscopy

U2 - 10.1021/acs.molpharmaceut.9b00557

DO - 10.1021/acs.molpharmaceut.9b00557

M3 - Journal article

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AN - SCOPUS:85070877326

SN - 1543-8384

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JO - Molecular Pharmaceutics

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