Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | International Journal of Cardiology |
| Vol/bind | 143 |
| Udgave nummer | 1 |
| Sider (fra-til) | 35-42 |
| Antal sider | 8 |
| ISSN | 0167-5273 |
| DOI | |
| Status | Udgivet - 2010 |
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I: International Journal of Cardiology, Bind 143, Nr. 1, 2010, s. 35-42.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Low grade inflammation as measured by levels of YKL-40
T2 - association with an increased overall and cardiovascular mortality rate in an elderly population
AU - Rathcke, Camilla Noelle
AU - Raymond, Ilan
AU - Kistorp, Caroline
AU - Hildebrandt, Per
AU - Faber, Jens
AU - Vestergaard, Henrik
N1 - Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
PY - 2010
Y1 - 2010
N2 - BACKGROUND: Low grade inflammation is of pathogenic importance in the development of cardiovascular disease (CVD) and type 2 diabetes. The inflammation marker YKL-40 correlates with insulin resistance and is highly expressed in atherosclerotic plaques. We aimed to investigate whether YKL-40 could predict overall and cardiovascular (CV) mortality in a 50+ years population without known CVD. METHODS: A representative population sample of 639 individuals aged 50-89 years was recruited from general practices. Examination at baseline included echocardiography and blood and urine samples for CV risk factors and markers including lipids, high sensitive C-reactive protein (hsCRP), N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP) and urinary albumin/creatinine-ratio (UACR). Median follow-up period was 5.0 (0.17-5.28) years. RESULTS: In subjects without diabetes and CVD at baseline, increasing YKL-40 levels independently predicted overall and CV mortality rate with hazard ratios of 1.58 (95% confidence interval (CI), 1.12-2.23, p=0.009) and 1.57 (95% CI, 1.00-2.46, p=0.049) after adjustment for age, sex, smoking, total cholesterol, hsCRP, NT-proBNP and UACR. In combined Kaplan-Meier analyses, baseline values of both YKL-40 and UACR above median significantly predicted increased cumulative overall and CV mortality rates in subjects without diabetes or CVD at baseline (30.6% vs.
AB - BACKGROUND: Low grade inflammation is of pathogenic importance in the development of cardiovascular disease (CVD) and type 2 diabetes. The inflammation marker YKL-40 correlates with insulin resistance and is highly expressed in atherosclerotic plaques. We aimed to investigate whether YKL-40 could predict overall and cardiovascular (CV) mortality in a 50+ years population without known CVD. METHODS: A representative population sample of 639 individuals aged 50-89 years was recruited from general practices. Examination at baseline included echocardiography and blood and urine samples for CV risk factors and markers including lipids, high sensitive C-reactive protein (hsCRP), N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP) and urinary albumin/creatinine-ratio (UACR). Median follow-up period was 5.0 (0.17-5.28) years. RESULTS: In subjects without diabetes and CVD at baseline, increasing YKL-40 levels independently predicted overall and CV mortality rate with hazard ratios of 1.58 (95% confidence interval (CI), 1.12-2.23, p=0.009) and 1.57 (95% CI, 1.00-2.46, p=0.049) after adjustment for age, sex, smoking, total cholesterol, hsCRP, NT-proBNP and UACR. In combined Kaplan-Meier analyses, baseline values of both YKL-40 and UACR above median significantly predicted increased cumulative overall and CV mortality rates in subjects without diabetes or CVD at baseline (30.6% vs.
U2 - 10.1016/j.ijcard.2009.01.043
DO - 10.1016/j.ijcard.2009.01.043
M3 - Journal article
C2 - 19223085
SN - 0167-5273
VL - 143
SP - 35
EP - 42
JO - International Journal of Cardiology
JF - International Journal of Cardiology
IS - 1
ER -