Low prevalence of DNA viruses in the human endometrium and endometriosis

Anna Lindeløv Vestergaard; Ulla Breth Knudsen; Torben Munk; Hanne Katrine Rosbach; Seweryn Bialasiewicz; Theo P. Sloots; Pia M. Martensen; Annika Antonsson

doi:10.1007/s00705-010-0643-y

Low prevalence of DNA viruses in the human endometrium and endometriosis

Anna Lindeløv Vestergaard, Ulla Breth Knudsen, Torben Munk, Hanne Katrine Rosbach, Seweryn Bialasiewicz, Theo P. Sloots, Pia M. Martensen, Annika Antonsson

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

27 Citationer (Scopus)

Abstract

The chronic female disease endometriosis causes debilitating pain and lowered fertility. The aetiology is unknown, but indications of an infectious agent are present. This study investigates the possible involvement of a pathogenic virus in endometriosis patients and controls. DNA was purified from biopsies and subjected to highly sensitive PCR tests detecting human papillomavirus (HPV) types, the herpes family viruses HSV-1 and -2, CMV, and EBV, and the polyomaviruses SV40, JCV, BKV, KIV, WUV, and MCV. The prevalence of pathogenic DNA viruses in the human endometrium was generally low (0-10%). The virus prevalence was found to vary slightly when comparing the endometrium of healthy women and women with endometriosis. However, these were not significant differences, and no viruses were identified in endometriotic lesions. These results do not point towards any evidence that endometriosis is caused by these viruses.

Originalsprog	Engelsk
Tidsskrift	Archives of Virology
Vol/bind	155
Sider (fra-til)	695-703
Antal sider	9
ISSN	0304-8608
DOI	https://doi.org/10.1007/s00705-010-0643-y
Status	Udgivet - 2010
Udgivet eksternt	Ja

Adgang til dokumentet

10.1007/s00705-010-0643-y

Citationsformater

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title = "Low prevalence of DNA viruses in the human endometrium and endometriosis",

abstract = "The chronic female disease endometriosis causes debilitating pain and lowered fertility. The aetiology is unknown, but indications of an infectious agent are present. This study investigates the possible involvement of a pathogenic virus in endometriosis patients and controls. DNA was purified from biopsies and subjected to highly sensitive PCR tests detecting human papillomavirus (HPV) types, the herpes family viruses HSV-1 and -2, CMV, and EBV, and the polyomaviruses SV40, JCV, BKV, KIV, WUV, and MCV. The prevalence of pathogenic DNA viruses in the human endometrium was generally low (0-10%). The virus prevalence was found to vary slightly when comparing the endometrium of healthy women and women with endometriosis. However, these were not significant differences, and no viruses were identified in endometriotic lesions. These results do not point towards any evidence that endometriosis is caused by these viruses.",

author = "Vestergaard, {Anna Lindel{\o}v} and Knudsen, {Ulla Breth} and Torben Munk and Rosbach, {Hanne Katrine} and Seweryn Bialasiewicz and Sloots, {Theo P.} and Martensen, {Pia M.} and Annika Antonsson",

year = "2010",

doi = "10.1007/s00705-010-0643-y",

language = "English",

volume = "155",

pages = "695--703",

journal = "Archives of Virology",

issn = "0304-8608",

publisher = "Springer Wien",

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TY - JOUR

T1 - Low prevalence of DNA viruses in the human endometrium and endometriosis

AU - Vestergaard, Anna Lindeløv

AU - Knudsen, Ulla Breth

AU - Munk, Torben

AU - Rosbach, Hanne Katrine

AU - Bialasiewicz, Seweryn

AU - Sloots, Theo P.

AU - Martensen, Pia M.

AU - Antonsson, Annika

PY - 2010

Y1 - 2010

N2 - The chronic female disease endometriosis causes debilitating pain and lowered fertility. The aetiology is unknown, but indications of an infectious agent are present. This study investigates the possible involvement of a pathogenic virus in endometriosis patients and controls. DNA was purified from biopsies and subjected to highly sensitive PCR tests detecting human papillomavirus (HPV) types, the herpes family viruses HSV-1 and -2, CMV, and EBV, and the polyomaviruses SV40, JCV, BKV, KIV, WUV, and MCV. The prevalence of pathogenic DNA viruses in the human endometrium was generally low (0-10%). The virus prevalence was found to vary slightly when comparing the endometrium of healthy women and women with endometriosis. However, these were not significant differences, and no viruses were identified in endometriotic lesions. These results do not point towards any evidence that endometriosis is caused by these viruses.

AB - The chronic female disease endometriosis causes debilitating pain and lowered fertility. The aetiology is unknown, but indications of an infectious agent are present. This study investigates the possible involvement of a pathogenic virus in endometriosis patients and controls. DNA was purified from biopsies and subjected to highly sensitive PCR tests detecting human papillomavirus (HPV) types, the herpes family viruses HSV-1 and -2, CMV, and EBV, and the polyomaviruses SV40, JCV, BKV, KIV, WUV, and MCV. The prevalence of pathogenic DNA viruses in the human endometrium was generally low (0-10%). The virus prevalence was found to vary slightly when comparing the endometrium of healthy women and women with endometriosis. However, these were not significant differences, and no viruses were identified in endometriotic lesions. These results do not point towards any evidence that endometriosis is caused by these viruses.

U2 - 10.1007/s00705-010-0643-y

DO - 10.1007/s00705-010-0643-y

M3 - Journal article

SN - 0304-8608

VL - 155

SP - 695

EP - 703

JO - Archives of Virology

JF - Archives of Virology

ER -