Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Clinical Endocrinology |
| Vol/bind | 71 |
| Udgave nummer | 3 |
| Sider (fra-til) | 440-5 |
| Antal sider | 5 |
| ISSN | 0300-0664 |
| DOI | |
| Status | Udgivet - 2009 |
Bibliografisk note
Keywords: Adolescent; Adult; Aged; Denmark; Female; Humans; Hyperthyroidism; Iodine; Male; Mandatory Programs; Middle Aged; Prevalence; Preventive Health Services; Program Evaluation; Prospective Studies; Sodium Chloride, Dietary; Thyroid Hormones; Young AdultAdgang til dokumentet
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Lower prevalence of mild hyperthyroidism related to a higher iodine intake in the population: prospective study of a mandatory iodization programme. / Vejbjerg, Pernille; Knudsen, Nils; Perrild, Hans; Laurberg, Peter; Carlé, Allan; Pedersen, Inge Bülow; Rasmussen, Lone B; Ovesen, Lars; Jørgensen, Torben.
I: Clinical Endocrinology, Bind 71, Nr. 3, 2009, s. 440-5.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Lower prevalence of mild hyperthyroidism related to a higher iodine intake in the population: prospective study of a mandatory iodization programme
AU - Vejbjerg, Pernille
AU - Knudsen, Nils
AU - Perrild, Hans
AU - Laurberg, Peter
AU - Carlé, Allan
AU - Pedersen, Inge Bülow
AU - Rasmussen, Lone B
AU - Ovesen, Lars
AU - Jørgensen, Torben
N1 - Keywords: Adolescent; Adult; Aged; Denmark; Female; Humans; Hyperthyroidism; Iodine; Male; Mandatory Programs; Middle Aged; Prevalence; Preventive Health Services; Program Evaluation; Prospective Studies; Sodium Chloride, Dietary; Thyroid Hormones; Young Adult
PY - 2009
Y1 - 2009
N2 - OBJECTIVE: Marked differences in pattern of thyroid dysfunction are seen in populations with different iodine intakes. We evaluated the influence of a higher iodine intake on thyroid hormone levels and the prevalence of thyroid dysfunction in the Danish population. DESIGN: Two cross-sectional studies matched on a group level according to sex and age. PARTICIPANTS: In all, 8219 individuals were examined before (n = 4649) or after (n = 3570) the introduction of a mandatory iodization programme in 2000 in two regions with established mild and moderate iodine deficiency. Serum TSH, fT(4) and fT(3 )were measured. An ultrasonography of the thyroid was performed. RESULTS: We found a higher median serum TSH after the introduction of mandatory iodization of salt: 1.51 mU/l (10-90th percentiles: 0.72-3.00) vs. 1.30 mU/l (10-90th percentiles: 0.59-2.66) before iodization. The difference was found in both regions and across age groups. There was a lower prevalence of mild hyperthyroidism and a tendency towards a lower prevalence of overt hyperthyroidism. The prevalence of mild hypothyroidism increased, most pronounced among young women after iodization. Conversely, there was a lower prevalence of undiagnosed overt hypothyroidism. However, when currently treated participants were included, the prevalence of hypothyroidism increased after iodization in the area with formerly mild iodine deficiency. CONCLUSION: A change in pattern of thyroid dysfunction was seen in relation to mandatory iodization of salt. There was no rise in the prevalence of hyperthyroidism and the prevalence of mild hyperthyroidism was halved. Conversely, prevalence of hypothyroidism increased.
AB - OBJECTIVE: Marked differences in pattern of thyroid dysfunction are seen in populations with different iodine intakes. We evaluated the influence of a higher iodine intake on thyroid hormone levels and the prevalence of thyroid dysfunction in the Danish population. DESIGN: Two cross-sectional studies matched on a group level according to sex and age. PARTICIPANTS: In all, 8219 individuals were examined before (n = 4649) or after (n = 3570) the introduction of a mandatory iodization programme in 2000 in two regions with established mild and moderate iodine deficiency. Serum TSH, fT(4) and fT(3 )were measured. An ultrasonography of the thyroid was performed. RESULTS: We found a higher median serum TSH after the introduction of mandatory iodization of salt: 1.51 mU/l (10-90th percentiles: 0.72-3.00) vs. 1.30 mU/l (10-90th percentiles: 0.59-2.66) before iodization. The difference was found in both regions and across age groups. There was a lower prevalence of mild hyperthyroidism and a tendency towards a lower prevalence of overt hyperthyroidism. The prevalence of mild hypothyroidism increased, most pronounced among young women after iodization. Conversely, there was a lower prevalence of undiagnosed overt hypothyroidism. However, when currently treated participants were included, the prevalence of hypothyroidism increased after iodization in the area with formerly mild iodine deficiency. CONCLUSION: A change in pattern of thyroid dysfunction was seen in relation to mandatory iodization of salt. There was no rise in the prevalence of hyperthyroidism and the prevalence of mild hyperthyroidism was halved. Conversely, prevalence of hypothyroidism increased.
U2 - 10.1111/j.1365-2265.2008.03493.x
DO - 10.1111/j.1365-2265.2008.03493.x
M3 - Journal article
C2 - 19067717
VL - 71
SP - 440
EP - 445
JO - Clinical Endocrinology
JF - Clinical Endocrinology
SN - 0300-0664
IS - 3
ER -