LTBI: latent tuberculosis infection or lasting immune responses to M. tuberculosis? A TBNET consensus statement

U Mack; G B Migliori; M Sester; H L Rieder; S Ehlers; D Goletti; A Bossink; K Magdorf; C Hölscher; B Kampmann; S M Arend; A Detjen; G Bothamley; J P Zellweger; H Milburn; R Diel; P Ravn; F Cobelens; P J Cardona; B Kan; I Solovic; R Duarte; D M Cirillo; C. Lange; TBNET

doi:10.1183/09031936.00120908

LTBI: latent tuberculosis infection or lasting immune responses to M. tuberculosis? A TBNET consensus statement

U Mack, G B Migliori, M Sester, H L Rieder, S Ehlers, D Goletti, A Bossink, K Magdorf, C Hölscher, B Kampmann, S M Arend, A Detjen, G Bothamley, J P Zellweger, H Milburn, R Diel, P Ravn, F Cobelens, P J Cardona, B KanI Solovic, R Duarte, D M Cirillo, C. Lange, TBNET

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

492 Citationer (Scopus)

Abstract

Udgivelsesdato: 2009-May

Originalsprog	Engelsk
Tidsskrift	European Respiratory Journal
Vol/bind	33
Udgave nummer	5
Sider (fra-til)	956-73
Antal sider	18
ISSN	0903-1936
DOI	https://doi.org/10.1183/09031936.00120908
Status	Udgivet - 2009

Bibliografisk note

Keywords: Antigens, Bacterial; Antitubercular Agents; Contact Tracing; Evidence-Based Medicine; Humans; Immunologic Tests; Mass Screening; Molecular Diagnostic Techniques; Mycobacterium tuberculosis; Patient Selection; Predictive Value of Tests; Tuberculin Test; Tuberculosis

Adgang til dokumentet

10.1183/09031936.00120908

Citationsformater

Mack, U., Migliori, G. B., Sester, M., Rieder, H. L., Ehlers, S., Goletti, D., Bossink, A., Magdorf, K., Hölscher, C., Kampmann, B., Arend, S. M., Detjen, A., Bothamley, G., Zellweger, J. P., Milburn, H., Diel, R., Ravn, P., Cobelens, F., Cardona, P. J., ... TBNET (2009). LTBI: latent tuberculosis infection or lasting immune responses to M. tuberculosis? A TBNET consensus statement. European Respiratory Journal, 33(5), 956-73. https://doi.org/10.1183/09031936.00120908

LTBI: latent tuberculosis infection or lasting immune responses to M. tuberculosis? A TBNET consensus statement. / Mack, U; Migliori, G B; Sester, M; Rieder, H L; Ehlers, S; Goletti, D; Bossink, A; Magdorf, K; Hölscher, C; Kampmann, B; Arend, S M; Detjen, A; Bothamley, G; Zellweger, J P; Milburn, H; Diel, R; Ravn, P; Cobelens, F; Cardona, P J; Kan, B; Solovic, I; Duarte, R; Cirillo, D M; C. Lange; TBNET.

I: European Respiratory Journal, Bind 33, Nr. 5, 2009, s. 956-73.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Mack, U, Migliori, GB, Sester, M, Rieder, HL, Ehlers, S, Goletti, D, Bossink, A, Magdorf, K, Hölscher, C, Kampmann, B, Arend, SM, Detjen, A, Bothamley, G, Zellweger, JP, Milburn, H, Diel, R, Ravn, P, Cobelens, F, Cardona, PJ, Kan, B, Solovic, I, Duarte, R, Cirillo, DM, C. Lange & TBNET 2009, 'LTBI: latent tuberculosis infection or lasting immune responses to M. tuberculosis? A TBNET consensus statement', European Respiratory Journal, bind 33, nr. 5, s. 956-73. https://doi.org/10.1183/09031936.00120908

Mack, U ; Migliori, G B ; Sester, M ; Rieder, H L ; Ehlers, S ; Goletti, D ; Bossink, A ; Magdorf, K ; Hölscher, C ; Kampmann, B ; Arend, S M ; Detjen, A ; Bothamley, G ; Zellweger, J P ; Milburn, H ; Diel, R ; Ravn, P ; Cobelens, F ; Cardona, P J ; Kan, B ; Solovic, I ; Duarte, R ; Cirillo, D M ; C. Lange ; TBNET. / LTBI: latent tuberculosis infection or lasting immune responses to M. tuberculosis? A TBNET consensus statement. I: European Respiratory Journal. 2009 ; Bind 33, Nr. 5. s. 956-73.

@article{23fbe830841711df928f000ea68e967b,

title = "LTBI: latent tuberculosis infection or lasting immune responses to M. tuberculosis? A TBNET consensus statement",

abstract = "Tuberculosis control relies on the identification and preventive treatment of individuals who are latently infected with Mycobacterium tuberculosis. However, direct identification of latent tuberculosis infection is not possible. The diagnostic tests used to identify individuals latently infected with M. tuberculosis, the in vivo tuberculin skin test and the ex vivo interferon-gamma release assays (IGRAs), are designed to identify an adaptive immune response against, but not necessarily a latent infection with, M. tuberculosis. The proportion of individuals who truly remain infected with M. tuberculosis after tuberculin skin test or IGRA conversion is unknown. It is also uncertain how long adaptive immune responses towards mycobacterial antigens persist in the absence of live mycobacteria. Clinical management and public healthcare policies for preventive chemotherapy against tuberculosis could be improved, if we were to gain a better understanding on M. tuberculosis latency and reactivation. This statement by the TBNET summarises knowledge and limitations of the currently available tests used in adults and children for the diagnosis of latent tuberculosis infection. In summary, the main issue regarding testing is to restrict it to those who are known to be at higher risk of developing tuberculosis and who are willing to accept preventive chemotherapy.",

author = "U Mack and Migliori, {G B} and M Sester and Rieder, {H L} and S Ehlers and D Goletti and A Bossink and K Magdorf and C H{\"o}lscher and B Kampmann and Arend, {S M} and A Detjen and G Bothamley and Zellweger, {J P} and H Milburn and R Diel and P Ravn and F Cobelens and Cardona, {P J} and B Kan and I Solovic and R Duarte and Cirillo, {D M} and {C. Lange} and TBNET",

note = "Keywords: Antigens, Bacterial; Antitubercular Agents; Contact Tracing; Evidence-Based Medicine; Humans; Immunologic Tests; Mass Screening; Molecular Diagnostic Techniques; Mycobacterium tuberculosis; Patient Selection; Predictive Value of Tests; Tuberculin Test; Tuberculosis",

year = "2009",

doi = "10.1183/09031936.00120908",

language = "English",

volume = "33",

pages = "956--73",

journal = "The European Respiratory Journal",

issn = "0903-1936",

publisher = "European Respiratory Society",

number = "5",

}

TY - JOUR

T1 - LTBI: latent tuberculosis infection or lasting immune responses to M. tuberculosis? A TBNET consensus statement

AU - Mack, U

AU - Migliori, G B

AU - Sester, M

AU - Rieder, H L

AU - Ehlers, S

AU - Goletti, D

AU - Bossink, A

AU - Magdorf, K

AU - Hölscher, C

AU - Kampmann, B

AU - Arend, S M

AU - Detjen, A

AU - Bothamley, G

AU - Zellweger, J P

AU - Milburn, H

AU - Diel, R

AU - Ravn, P

AU - Cobelens, F

AU - Cardona, P J

AU - Kan, B

AU - Solovic, I

AU - Duarte, R

AU - Cirillo, D M

AU - C. Lange

AU - TBNET

N1 - Keywords: Antigens, Bacterial; Antitubercular Agents; Contact Tracing; Evidence-Based Medicine; Humans; Immunologic Tests; Mass Screening; Molecular Diagnostic Techniques; Mycobacterium tuberculosis; Patient Selection; Predictive Value of Tests; Tuberculin Test; Tuberculosis

PY - 2009

Y1 - 2009

N2 - Tuberculosis control relies on the identification and preventive treatment of individuals who are latently infected with Mycobacterium tuberculosis. However, direct identification of latent tuberculosis infection is not possible. The diagnostic tests used to identify individuals latently infected with M. tuberculosis, the in vivo tuberculin skin test and the ex vivo interferon-gamma release assays (IGRAs), are designed to identify an adaptive immune response against, but not necessarily a latent infection with, M. tuberculosis. The proportion of individuals who truly remain infected with M. tuberculosis after tuberculin skin test or IGRA conversion is unknown. It is also uncertain how long adaptive immune responses towards mycobacterial antigens persist in the absence of live mycobacteria. Clinical management and public healthcare policies for preventive chemotherapy against tuberculosis could be improved, if we were to gain a better understanding on M. tuberculosis latency and reactivation. This statement by the TBNET summarises knowledge and limitations of the currently available tests used in adults and children for the diagnosis of latent tuberculosis infection. In summary, the main issue regarding testing is to restrict it to those who are known to be at higher risk of developing tuberculosis and who are willing to accept preventive chemotherapy.

AB - Tuberculosis control relies on the identification and preventive treatment of individuals who are latently infected with Mycobacterium tuberculosis. However, direct identification of latent tuberculosis infection is not possible. The diagnostic tests used to identify individuals latently infected with M. tuberculosis, the in vivo tuberculin skin test and the ex vivo interferon-gamma release assays (IGRAs), are designed to identify an adaptive immune response against, but not necessarily a latent infection with, M. tuberculosis. The proportion of individuals who truly remain infected with M. tuberculosis after tuberculin skin test or IGRA conversion is unknown. It is also uncertain how long adaptive immune responses towards mycobacterial antigens persist in the absence of live mycobacteria. Clinical management and public healthcare policies for preventive chemotherapy against tuberculosis could be improved, if we were to gain a better understanding on M. tuberculosis latency and reactivation. This statement by the TBNET summarises knowledge and limitations of the currently available tests used in adults and children for the diagnosis of latent tuberculosis infection. In summary, the main issue regarding testing is to restrict it to those who are known to be at higher risk of developing tuberculosis and who are willing to accept preventive chemotherapy.

U2 - 10.1183/09031936.00120908

DO - 10.1183/09031936.00120908

M3 - Journal article

C2 - 19407047

VL - 33

SP - 956

EP - 973

JO - The European Respiratory Journal

JF - The European Respiratory Journal

SN - 0903-1936

IS - 5

ER -