TY - JOUR
T1 - LUPA
T2 - a European initiative taking advantage of the canine genome architecture for unravelling complex disorders in both human and dogs
AU - Lequarré, Anne-Sophie
AU - Andersson, Leif
AU - André, Catherine
AU - Fredholm, Merete
AU - Hitte, Christophe
AU - Leeb, Tosso
AU - Lohi, Hannes
AU - Lindblad-Toh, Kerstin
AU - Georges, Michel
PY - 2011
Y1 - 2011
N2 - The domestic dog offers a unique opportunity to explore the genetic basis of disease, morphology and behaviour. Humans share many diseases with our canine companions, making dogs an ideal model organism for comparative disease genetics. Using newly developed resources, genome-wide association studies in dog breeds are proving to be exceptionally powerful. Towards this aim, veterinarians and geneticists from 12 European countries are collaborating to collect and analyse the DNA from large cohorts of dogs suffering from a range of carefully defined diseases of relevance to human health. This project, named LUPA, has already delivered considerable results. The consortium has collaborated to develop a new high density single nucleotide polymorphism (SNP) array. Mutations for four monogenic diseases have been identified and the information has been utilised to find mutations in human patients. Several complex diseases have been mapped and fine mapping is underway. These findings should ultimately lead to a better understanding of the molecular mechanisms underlying complex diseases in both humans and their best friend.
AB - The domestic dog offers a unique opportunity to explore the genetic basis of disease, morphology and behaviour. Humans share many diseases with our canine companions, making dogs an ideal model organism for comparative disease genetics. Using newly developed resources, genome-wide association studies in dog breeds are proving to be exceptionally powerful. Towards this aim, veterinarians and geneticists from 12 European countries are collaborating to collect and analyse the DNA from large cohorts of dogs suffering from a range of carefully defined diseases of relevance to human health. This project, named LUPA, has already delivered considerable results. The consortium has collaborated to develop a new high density single nucleotide polymorphism (SNP) array. Mutations for four monogenic diseases have been identified and the information has been utilised to find mutations in human patients. Several complex diseases have been mapped and fine mapping is underway. These findings should ultimately lead to a better understanding of the molecular mechanisms underlying complex diseases in both humans and their best friend.
U2 - 10.1016/j.tvjl.2011.06.013
DO - 10.1016/j.tvjl.2011.06.013
M3 - Journal article
VL - 189
SP - 155
EP - 159
JO - The Veterinary Journal
JF - The Veterinary Journal
SN - 1090-0233
IS - 2
ER -