Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma

Sasha Bernatsky; Héctor A.Velásquez García; John J. Spinelli; Patrick Gaffney; Karin E. Smedby; Rosalind Ramsey-Goldman; Sophia S. Wang; Hans Olov Adami; Demetrius Albanes; Emanuele Angelucci; Stephen M. Ansell; Yan WAsmann; Nikolaus Becker; Yolanda Benavente; Sonja I. Berndt; Kimberly A. Bertrand; Brenda M. Birmann; Heiner Boeing; Paolo Boffetta; Paige M. Bracci; Paul Brennan; Angela R. Brooks-Wilson; James R. Cerhan; Stephen J. Chanock; Jacqueline Clavel; Lucia Conde; Karen H. Cotenbader; David G. Cox; Wendy Cozen; Simon Crouch; Anneclaire J. De Roos; Silvia De Sanjose; Simonetta Di Lollo; W. Ryan Diver; Ahmet Dogan; Lenka Foretova; Hervé Ghesquières; Graham G. Giles; Bengt Glimelius; Thomas M. Habermann; Corinne Haioun; Patricia Hartge; Henrik Hjalgrim; Theodore R. Holford; Elizabeth A. Holly; Rebecca D. Jackson; Rudolph Kaaks; Eleanor Kane; Rachel S. Kelly; Robert J. Klein; Peter Kraft; Anne Kricker; Qing Lan; Charles Lawrence; Mark Liebow; Tracy Lightfoot; Brian K. Link; Marc Maynadie; James McKay; Mads Melbye; Thierry J. Molina; Alain Monnereau; Lindsay M. Morton; Alexandra Nieters; Kari E. North; Anne J. Novak; Kenneth Offit; Mark P. Purdue; Marco Rais; Jacques Riby; Eve Roman; Nathaniel Rothman; Gilles Salles; Gianluca Severi; Richard K. Severson; Christine F. Skibola; Susan L. Slager; Alex Smith; Martyn T. Smith; Melissa C. Southey; Anthony Staines; Lauren R. Teras; Carrie A. Thompson; Hervé Tilly; Lesley F. Tinker; Anne Tjonneland; Jenny Turner; Claire M. Vajdic; Roel C.H. Vermeulen; Joseph Vijai; Paolo Vineis; Jarmo Virtamo; Zhaoming Wang; Stephanie Weinstein; Thomas E. Witzig; Andrew Zelenetz; Anne Zeleniuch-Jacquotte; Yawei Zhang; Tongzhang Zheng; Mariagrazia Zucca; Ann E. Clarke

doi:10.1136/lupus-2016-000187

Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma

Sasha Bernatsky^*, Héctor A.Velásquez García, John J. Spinelli, Patrick Gaffney, Karin E. Smedby, Rosalind Ramsey-Goldman, Sophia S. Wang, Hans Olov Adami, Demetrius Albanes, Emanuele Angelucci, Stephen M. Ansell, Yan WAsmann, Nikolaus Becker, Yolanda Benavente, Sonja I. Berndt, Kimberly A. Bertrand, Brenda M. Birmann, Heiner Boeing, Paolo Boffetta, Paige M. BracciPaul Brennan, Angela R. Brooks-Wilson, James R. Cerhan, Stephen J. Chanock, Jacqueline Clavel, Lucia Conde, Karen H. Cotenbader, David G. Cox, Wendy Cozen, Simon Crouch, Anneclaire J. De Roos, Silvia De Sanjose, Simonetta Di Lollo, W. Ryan Diver, Ahmet Dogan, Lenka Foretova, Hervé Ghesquières, Graham G. Giles, Bengt Glimelius, Thomas M. Habermann, Corinne Haioun, Patricia Hartge, Henrik Hjalgrim, Theodore R. Holford, Elizabeth A. Holly, Rebecca D. Jackson, Rudolph Kaaks, Eleanor Kane, Rachel S. Kelly, Robert J. Klein, Peter Kraft, Anne Kricker, Qing Lan, Charles Lawrence, Mark Liebow, Tracy Lightfoot, Brian K. Link, Marc Maynadie, James McKay, Mads Melbye, Thierry J. Molina, Alain Monnereau, Lindsay M. Morton, Alexandra Nieters, Kari E. North, Anne J. Novak, Kenneth Offit, Mark P. Purdue, Marco Rais, Jacques Riby, Eve Roman, Nathaniel Rothman, Gilles Salles, Gianluca Severi, Richard K. Severson, Christine F. Skibola, Susan L. Slager, Alex Smith, Martyn T. Smith, Melissa C. Southey, Anthony Staines, Lauren R. Teras, Carrie A. Thompson, Hervé Tilly, Lesley F. Tinker, Anne Tjonneland, Jenny Turner, Claire M. Vajdic, Roel C.H. Vermeulen, Joseph Vijai, Paolo Vineis, Jarmo Virtamo, Zhaoming Wang, Stephanie Weinstein, Thomas E. Witzig, Andrew Zelenetz, Anne Zeleniuch-Jacquotte, Yawei Zhang, Tongzhang Zheng, Mariagrazia Zucca, Ann E. Clarke

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

16 Citationer (Scopus)

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Abstract

Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genomewide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL. Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis. Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765. Conclusions: These data suggest several plausible genetic links between DLBCL and SLE.

Originalsprog	Engelsk
Artikelnummer	e000187
Tidsskrift	Lupus Science and Medicine
Vol/bind	4
Udgave nummer	1
DOI	https://doi.org/10.1136/lupus-2016-000187
Status	Udgivet - jan. 2017

Adgang til dokumentet

10.1136/lupus-2016-000187Licens: CC BY

Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphomaForlagets udgivne version, 522 KBLicens: CC BY

Citationsformater

Bernatsky, S., García, H. A. V., Spinelli, J. J., Gaffney, P., Smedby, K. E., Ramsey-Goldman, R., Wang, S. S., Adami, H. O., Albanes, D., Angelucci, E., Ansell, S. M., WAsmann, Y., Becker, N., Benavente, Y., Berndt, S. I., Bertrand, K. A., Birmann, B. M., Boeing, H., Boffetta, P., ... Clarke, A. E. (2017). Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma. Lupus Science and Medicine, 4(1), [e000187]. https://doi.org/10.1136/lupus-2016-000187

Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma. / Bernatsky, Sasha; García, Héctor A.Velásquez; Spinelli, John J.; Gaffney, Patrick; Smedby, Karin E.; Ramsey-Goldman, Rosalind; Wang, Sophia S.; Adami, Hans Olov; Albanes, Demetrius; Angelucci, Emanuele; Ansell, Stephen M.; WAsmann, Yan; Becker, Nikolaus; Benavente, Yolanda; Berndt, Sonja I.; Bertrand, Kimberly A.; Birmann, Brenda M.; Boeing, Heiner; Boffetta, Paolo; Bracci, Paige M.; Brennan, Paul; Brooks-Wilson, Angela R.; Cerhan, James R.; Chanock, Stephen J.; Clavel, Jacqueline; Conde, Lucia; Cotenbader, Karen H.; Cox, David G.; Cozen, Wendy; Crouch, Simon; De Roos, Anneclaire J.; De Sanjose, Silvia; Di Lollo, Simonetta; Diver, W. Ryan; Dogan, Ahmet; Foretova, Lenka; Ghesquières, Hervé; Giles, Graham G.; Glimelius, Bengt; Habermann, Thomas M.; Haioun, Corinne; Hartge, Patricia; Hjalgrim, Henrik; Holford, Theodore R.; Holly, Elizabeth A.; Jackson, Rebecca D.; Kaaks, Rudolph; Kane, Eleanor; Kelly, Rachel S.; Klein, Robert J.; Kraft, Peter; Kricker, Anne; Lan, Qing; Lawrence, Charles; Liebow, Mark; Lightfoot, Tracy; Link, Brian K.; Maynadie, Marc; McKay, James; Melbye, Mads; Molina, Thierry J.; Monnereau, Alain; Morton, Lindsay M.; Nieters, Alexandra; North, Kari E.; Novak, Anne J.; Offit, Kenneth; Purdue, Mark P.; Rais, Marco; Riby, Jacques; Roman, Eve; Rothman, Nathaniel; Salles, Gilles; Severi, Gianluca; Severson, Richard K.; Skibola, Christine F.; Slager, Susan L.; Smith, Alex; Smith, Martyn T.; Southey, Melissa C.; Staines, Anthony; Teras, Lauren R.; Thompson, Carrie A.; Tilly, Hervé; Tinker, Lesley F.; Tjonneland, Anne; Turner, Jenny; Vajdic, Claire M.; Vermeulen, Roel C.H.; Vijai, Joseph; Vineis, Paolo; Virtamo, Jarmo; Wang, Zhaoming; Weinstein, Stephanie; Witzig, Thomas E.; Zelenetz, Andrew; Zeleniuch-Jacquotte, Anne; Zhang, Yawei; Zheng, Tongzhang; Zucca, Mariagrazia; Clarke, Ann E.

I: Lupus Science and Medicine, Bind 4, Nr. 1, e000187, 01.2017.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Bernatsky, S, García, HAV, Spinelli, JJ, Gaffney, P, Smedby, KE, Ramsey-Goldman, R, Wang, SS, Adami, HO, Albanes, D, Angelucci, E, Ansell, SM, WAsmann, Y, Becker, N, Benavente, Y, Berndt, SI, Bertrand, KA, Birmann, BM, Boeing, H, Boffetta, P, Bracci, PM, Brennan, P, Brooks-Wilson, AR, Cerhan, JR, Chanock, SJ, Clavel, J, Conde, L, Cotenbader, KH, Cox, DG, Cozen, W, Crouch, S, De Roos, AJ, De Sanjose, S, Di Lollo, S, Diver, WR, Dogan, A, Foretova, L, Ghesquières, H, Giles, GG, Glimelius, B, Habermann, TM, Haioun, C, Hartge, P, Hjalgrim, H, Holford, TR, Holly, EA, Jackson, RD, Kaaks, R, Kane, E, Kelly, RS, Klein, RJ, Kraft, P, Kricker, A, Lan, Q, Lawrence, C, Liebow, M, Lightfoot, T, Link, BK, Maynadie, M, McKay, J, Melbye, M, Molina, TJ, Monnereau, A, Morton, LM, Nieters, A, North, KE, Novak, AJ, Offit, K, Purdue, MP, Rais, M, Riby, J, Roman, E, Rothman, N, Salles, G, Severi, G, Severson, RK, Skibola, CF, Slager, SL, Smith, A, Smith, MT, Southey, MC, Staines, A, Teras, LR, Thompson, CA, Tilly, H, Tinker, LF, Tjonneland, A, Turner, J, Vajdic, CM, Vermeulen, RCH, Vijai, J, Vineis, P, Virtamo, J, Wang, Z, Weinstein, S, Witzig, TE, Zelenetz, A, Zeleniuch-Jacquotte, A, Zhang, Y, Zheng, T, Zucca, M & Clarke, AE 2017, 'Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma', Lupus Science and Medicine, bind 4, nr. 1, e000187. https://doi.org/10.1136/lupus-2016-000187

Bernatsky, Sasha ; García, Héctor A.Velásquez ; Spinelli, John J. ; Gaffney, Patrick ; Smedby, Karin E. ; Ramsey-Goldman, Rosalind ; Wang, Sophia S. ; Adami, Hans Olov ; Albanes, Demetrius ; Angelucci, Emanuele ; Ansell, Stephen M. ; WAsmann, Yan ; Becker, Nikolaus ; Benavente, Yolanda ; Berndt, Sonja I. ; Bertrand, Kimberly A. ; Birmann, Brenda M. ; Boeing, Heiner ; Boffetta, Paolo ; Bracci, Paige M. ; Brennan, Paul ; Brooks-Wilson, Angela R. ; Cerhan, James R. ; Chanock, Stephen J. ; Clavel, Jacqueline ; Conde, Lucia ; Cotenbader, Karen H. ; Cox, David G. ; Cozen, Wendy ; Crouch, Simon ; De Roos, Anneclaire J. ; De Sanjose, Silvia ; Di Lollo, Simonetta ; Diver, W. Ryan ; Dogan, Ahmet ; Foretova, Lenka ; Ghesquières, Hervé ; Giles, Graham G. ; Glimelius, Bengt ; Habermann, Thomas M. ; Haioun, Corinne ; Hartge, Patricia ; Hjalgrim, Henrik ; Holford, Theodore R. ; Holly, Elizabeth A. ; Jackson, Rebecca D. ; Kaaks, Rudolph ; Kane, Eleanor ; Kelly, Rachel S. ; Klein, Robert J. ; Kraft, Peter ; Kricker, Anne ; Lan, Qing ; Lawrence, Charles ; Liebow, Mark ; Lightfoot, Tracy ; Link, Brian K. ; Maynadie, Marc ; McKay, James ; Melbye, Mads ; Molina, Thierry J. ; Monnereau, Alain ; Morton, Lindsay M. ; Nieters, Alexandra ; North, Kari E. ; Novak, Anne J. ; Offit, Kenneth ; Purdue, Mark P. ; Rais, Marco ; Riby, Jacques ; Roman, Eve ; Rothman, Nathaniel ; Salles, Gilles ; Severi, Gianluca ; Severson, Richard K. ; Skibola, Christine F. ; Slager, Susan L. ; Smith, Alex ; Smith, Martyn T. ; Southey, Melissa C. ; Staines, Anthony ; Teras, Lauren R. ; Thompson, Carrie A. ; Tilly, Hervé ; Tinker, Lesley F. ; Tjonneland, Anne ; Turner, Jenny ; Vajdic, Claire M. ; Vermeulen, Roel C.H. ; Vijai, Joseph ; Vineis, Paolo ; Virtamo, Jarmo ; Wang, Zhaoming ; Weinstein, Stephanie ; Witzig, Thomas E. ; Zelenetz, Andrew ; Zeleniuch-Jacquotte, Anne ; Zhang, Yawei ; Zheng, Tongzhang ; Zucca, Mariagrazia ; Clarke, Ann E. / Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma. I: Lupus Science and Medicine. 2017 ; Bind 4, Nr. 1.

@article{4cb24ed224eb4e6890b138e13360204f,

title = "Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma",

abstract = "Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genomewide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL. Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis. Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765. Conclusions: These data suggest several plausible genetic links between DLBCL and SLE.",

author = "Sasha Bernatsky and Garc{\'i}a, {H{\'e}ctor A.Vel{\'a}squez} and Spinelli, {John J.} and Patrick Gaffney and Smedby, {Karin E.} and Rosalind Ramsey-Goldman and Wang, {Sophia S.} and Adami, {Hans Olov} and Demetrius Albanes and Emanuele Angelucci and Ansell, {Stephen M.} and Yan WAsmann and Nikolaus Becker and Yolanda Benavente and Berndt, {Sonja I.} and Bertrand, {Kimberly A.} and Birmann, {Brenda M.} and Heiner Boeing and Paolo Boffetta and Bracci, {Paige M.} and Paul Brennan and Brooks-Wilson, {Angela R.} and Cerhan, {James R.} and Chanock, {Stephen J.} and Jacqueline Clavel and Lucia Conde and Cotenbader, {Karen H.} and Cox, {David G.} and Wendy Cozen and Simon Crouch and {De Roos}, {Anneclaire J.} and {De Sanjose}, Silvia and {Di Lollo}, Simonetta and Diver, {W. Ryan} and Ahmet Dogan and Lenka Foretova and Herv{\'e} Ghesqui{\`e}res and Giles, {Graham G.} and Bengt Glimelius and Habermann, {Thomas M.} and Corinne Haioun and Patricia Hartge and Henrik Hjalgrim and Holford, {Theodore R.} and Holly, {Elizabeth A.} and Jackson, {Rebecca D.} and Rudolph Kaaks and Eleanor Kane and Kelly, {Rachel S.} and Klein, {Robert J.} and Peter Kraft and Anne Kricker and Qing Lan and Charles Lawrence and Mark Liebow and Tracy Lightfoot and Link, {Brian K.} and Marc Maynadie and James McKay and Mads Melbye and Molina, {Thierry J.} and Alain Monnereau and Morton, {Lindsay M.} and Alexandra Nieters and North, {Kari E.} and Novak, {Anne J.} and Kenneth Offit and Purdue, {Mark P.} and Marco Rais and Jacques Riby and Eve Roman and Nathaniel Rothman and Gilles Salles and Gianluca Severi and Severson, {Richard K.} and Skibola, {Christine F.} and Slager, {Susan L.} and Alex Smith and Smith, {Martyn T.} and Southey, {Melissa C.} and Anthony Staines and Teras, {Lauren R.} and Thompson, {Carrie A.} and Herv{\'e} Tilly and Tinker, {Lesley F.} and Anne Tjonneland and Jenny Turner and Vajdic, {Claire M.} and Vermeulen, {Roel C.H.} and Joseph Vijai and Paolo Vineis and Jarmo Virtamo and Zhaoming Wang and Stephanie Weinstein and Witzig, {Thomas E.} and Andrew Zelenetz and Anne Zeleniuch-Jacquotte and Yawei Zhang and Tongzhang Zheng and Mariagrazia Zucca and Clarke, {Ann E.}",

year = "2017",

month = jan,

doi = "10.1136/lupus-2016-000187",

language = "English",

volume = "4",

journal = "Lupus Science and Medicine",

issn = "2053-8790",

publisher = "BMJ Publishing Group",

number = "1",

}

TY - JOUR

T1 - Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma

AU - Bernatsky, Sasha

AU - García, Héctor A.Velásquez

AU - Spinelli, John J.

AU - Gaffney, Patrick

AU - Smedby, Karin E.

AU - Ramsey-Goldman, Rosalind

AU - Wang, Sophia S.

AU - Adami, Hans Olov

AU - Albanes, Demetrius

AU - Angelucci, Emanuele

AU - Ansell, Stephen M.

AU - WAsmann, Yan

AU - Becker, Nikolaus

AU - Benavente, Yolanda

AU - Berndt, Sonja I.

AU - Bertrand, Kimberly A.

AU - Birmann, Brenda M.

AU - Boeing, Heiner

AU - Boffetta, Paolo

AU - Bracci, Paige M.

AU - Brennan, Paul

AU - Brooks-Wilson, Angela R.

AU - Cerhan, James R.

AU - Chanock, Stephen J.

AU - Clavel, Jacqueline

AU - Conde, Lucia

AU - Cotenbader, Karen H.

AU - Cox, David G.

AU - Cozen, Wendy

AU - Crouch, Simon

AU - De Roos, Anneclaire J.

AU - De Sanjose, Silvia

AU - Di Lollo, Simonetta

AU - Diver, W. Ryan

AU - Dogan, Ahmet

AU - Foretova, Lenka

AU - Ghesquières, Hervé

AU - Giles, Graham G.

AU - Glimelius, Bengt

AU - Habermann, Thomas M.

AU - Haioun, Corinne

AU - Hartge, Patricia

AU - Hjalgrim, Henrik

AU - Holford, Theodore R.

AU - Holly, Elizabeth A.

AU - Jackson, Rebecca D.

AU - Kaaks, Rudolph

AU - Kane, Eleanor

AU - Kelly, Rachel S.

AU - Klein, Robert J.

AU - Kraft, Peter

AU - Kricker, Anne

AU - Lan, Qing

AU - Lawrence, Charles

AU - Liebow, Mark

AU - Lightfoot, Tracy

AU - Link, Brian K.

AU - Maynadie, Marc

AU - McKay, James

AU - Melbye, Mads

AU - Molina, Thierry J.

AU - Monnereau, Alain

AU - Morton, Lindsay M.

AU - Nieters, Alexandra

AU - North, Kari E.

AU - Novak, Anne J.

AU - Offit, Kenneth

AU - Purdue, Mark P.

AU - Rais, Marco

AU - Riby, Jacques

AU - Roman, Eve

AU - Rothman, Nathaniel

AU - Salles, Gilles

AU - Severi, Gianluca

AU - Severson, Richard K.

AU - Skibola, Christine F.

AU - Slager, Susan L.

AU - Smith, Alex

AU - Smith, Martyn T.

AU - Southey, Melissa C.

AU - Staines, Anthony

AU - Teras, Lauren R.

AU - Thompson, Carrie A.

AU - Tilly, Hervé

AU - Tinker, Lesley F.

AU - Tjonneland, Anne

AU - Turner, Jenny

AU - Vajdic, Claire M.

AU - Vermeulen, Roel C.H.

AU - Vijai, Joseph

AU - Vineis, Paolo

AU - Virtamo, Jarmo

AU - Wang, Zhaoming

AU - Weinstein, Stephanie

AU - Witzig, Thomas E.

AU - Zelenetz, Andrew

AU - Zeleniuch-Jacquotte, Anne

AU - Zhang, Yawei

AU - Zheng, Tongzhang

AU - Zucca, Mariagrazia

AU - Clarke, Ann E.

PY - 2017/1

Y1 - 2017/1

N2 - Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genomewide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL. Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis. Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765. Conclusions: These data suggest several plausible genetic links between DLBCL and SLE.

AB - Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genomewide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL. Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis. Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765. Conclusions: These data suggest several plausible genetic links between DLBCL and SLE.

U2 - 10.1136/lupus-2016-000187

DO - 10.1136/lupus-2016-000187

M3 - Journal article

AN - SCOPUS:85037860713

VL - 4

JO - Lupus Science and Medicine

JF - Lupus Science and Medicine

SN - 2053-8790

IS - 1

M1 - e000187

ER -