Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines

M Lundh; D P Christensen; D N Rasmussen; P Mascagni; C A Dinarello; N Billestrup; L G Grunnet; T Mandrup-Poulsen

doi:10.1007/s00125-010-1892-8

Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines

M Lundh, D P Christensen, D N Rasmussen, P Mascagni, C A Dinarello, N Billestrup, L G Grunnet, T Mandrup-Poulsen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

67 Citationer (Scopus)

Abstract

Cytokine-induced beta cell toxicity is abrogated by non-selective inhibitors of lysine deacetylases (KDACs). The KDAC family consists of 11 members, namely histone deacetylases HDAC1 to HDAC11, but it is not known which KDAC members play a role in cytokine-mediated beta cell death. The aim of the present study was to examine the KDAC gene expression profile of the beta cell and to investigate whether KDAC expression is regulated by cytokines. In addition, the protective effect of the non-selective KDAC inhibitor ITF2357 and interdependent regulation of four selected KDACs were investigated.

Originalsprog	Engelsk
Tidsskrift	Diabetologia
Vol/bind	53
Udgave nummer	12
Sider (fra-til)	2569-78
Antal sider	10
ISSN	0012-186X
DOI	https://doi.org/10.1007/s00125-010-1892-8
Status	Udgivet - 1 dec. 2010

Adgang til dokumentet

10.1007/s00125-010-1892-8

Citationsformater

Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines. / Lundh, M; Christensen, D P; Rasmussen, D N; Mascagni, P; Dinarello, C A; Billestrup, N; Grunnet, L G; Mandrup-Poulsen, T.

I: Diabetologia, Bind 53, Nr. 12, 01.12.2010, s. 2569-78.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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AU - Lundh, M

AU - Christensen, D P

AU - Rasmussen, D N

AU - Mascagni, P

AU - Dinarello, C A

AU - Billestrup, N

AU - Grunnet, L G

AU - Mandrup-Poulsen, T

PY - 2010/12/1

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N2 - Cytokine-induced beta cell toxicity is abrogated by non-selective inhibitors of lysine deacetylases (KDACs). The KDAC family consists of 11 members, namely histone deacetylases HDAC1 to HDAC11, but it is not known which KDAC members play a role in cytokine-mediated beta cell death. The aim of the present study was to examine the KDAC gene expression profile of the beta cell and to investigate whether KDAC expression is regulated by cytokines. In addition, the protective effect of the non-selective KDAC inhibitor ITF2357 and interdependent regulation of four selected KDACs were investigated.

AB - Cytokine-induced beta cell toxicity is abrogated by non-selective inhibitors of lysine deacetylases (KDACs). The KDAC family consists of 11 members, namely histone deacetylases HDAC1 to HDAC11, but it is not known which KDAC members play a role in cytokine-mediated beta cell death. The aim of the present study was to examine the KDAC gene expression profile of the beta cell and to investigate whether KDAC expression is regulated by cytokines. In addition, the protective effect of the non-selective KDAC inhibitor ITF2357 and interdependent regulation of four selected KDACs were investigated.

U2 - 10.1007/s00125-010-1892-8

DO - 10.1007/s00125-010-1892-8

M3 - Journal article

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VL - 53

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JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 12

ER -