Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | American Journal of Clinical Nutrition |
| Vol/bind | 89 |
| Udgave nummer | 5 |
| Sider (fra-til) | 1425-32 |
| Antal sider | 8 |
| ISSN | 0002-9165 |
| DOI | |
| Status | Udgivet - 2009 |
Bibliografisk note
Keywords: Adult; Aged; Cholesterol, LDL; Cohort Studies; Coronary Disease; Dietary Carbohydrates; Dietary Fats; Europe; Fatty Acids; Fatty Acids, Monounsaturated; Humans; Middle Aged; Proportional Hazards Models; Questionnaires; United StatesAdgang til dokumentet
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I: American Journal of Clinical Nutrition, Bind 89, Nr. 5, 2009, s. 1425-32.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies
AU - Jakobsen, Marianne Uhre
AU - O'Reilly, Eilis J
AU - Heitmann, Berit Lilienthal
AU - Pereira, Mark A
AU - Bälter, Katarina
AU - Fraser, Gary E
AU - Goldbourt, Uri
AU - Hallmans, Göran
AU - Knekt, Paul
AU - Liu, Simin
AU - Pietinen, Pirjo
AU - Spiegelman, Donna
AU - Stevens, June
AU - Virtamo, Jarmo
AU - Willett, Walter C
AU - Ascherio, Alberto
N1 - Keywords: Adult; Aged; Cholesterol, LDL; Cohort Studies; Coronary Disease; Dietary Carbohydrates; Dietary Fats; Europe; Fatty Acids; Fatty Acids, Monounsaturated; Humans; Middle Aged; Proportional Hazards Models; Questionnaires; United States
PY - 2009
Y1 - 2009
N2 - BACKGROUND: Saturated fatty acid (SFA) intake increases plasma LDL-cholesterol concentrations; therefore, intake should be reduced to prevent coronary heart disease (CHD). Lower habitual intakes of SFAs, however, require substitution of other macronutrients to maintain energy balance. OBJECTIVE: We investigated associations between energy intake from monounsaturated fatty acids (MUFAs), polyunsaturated fatty acids (PUFAs), and carbohydrates and risk of CHD while assessing the potential effect-modifying role of sex and age. Using substitution models, our aim was to clarify whether energy from unsaturated fatty acids or carbohydrates should replace energy from SFAs to prevent CHD. DESIGN: This was a follow-up study in which data from 11 American and European cohort studies were pooled. The outcome measure was incident CHD. RESULTS: During 4-10 y of follow-up, 5249 coronary events and 2155 coronary deaths occurred among 344,696 persons. For a 5% lower energy intake from SFAs and a concomitant higher energy intake from PUFAs, there was a significant inverse association between PUFAs and risk of coronary events (hazard ratio: 0.87; 95% CI: 0.77, 0.97); the hazard ratio for coronary deaths was 0.74 (95% CI: 0.61, 0.89). For a 5% lower energy intake from SFAs and a concomitant higher energy intake from carbohydrates, there was a modest significant direct association between carbohydrates and coronary events (hazard ratio: 1.07; 95% CI: 1.01, 1.14); the hazard ratio for coronary deaths was 0.96 (95% CI: 0.82, 1.13). MUFA intake was not associated with CHD. No effect modification by sex or age was found. CONCLUSION: The associations suggest that replacing SFAs with PUFAs rather than MUFAs or carbohydrates prevents CHD over a wide range of intakes.
AB - BACKGROUND: Saturated fatty acid (SFA) intake increases plasma LDL-cholesterol concentrations; therefore, intake should be reduced to prevent coronary heart disease (CHD). Lower habitual intakes of SFAs, however, require substitution of other macronutrients to maintain energy balance. OBJECTIVE: We investigated associations between energy intake from monounsaturated fatty acids (MUFAs), polyunsaturated fatty acids (PUFAs), and carbohydrates and risk of CHD while assessing the potential effect-modifying role of sex and age. Using substitution models, our aim was to clarify whether energy from unsaturated fatty acids or carbohydrates should replace energy from SFAs to prevent CHD. DESIGN: This was a follow-up study in which data from 11 American and European cohort studies were pooled. The outcome measure was incident CHD. RESULTS: During 4-10 y of follow-up, 5249 coronary events and 2155 coronary deaths occurred among 344,696 persons. For a 5% lower energy intake from SFAs and a concomitant higher energy intake from PUFAs, there was a significant inverse association between PUFAs and risk of coronary events (hazard ratio: 0.87; 95% CI: 0.77, 0.97); the hazard ratio for coronary deaths was 0.74 (95% CI: 0.61, 0.89). For a 5% lower energy intake from SFAs and a concomitant higher energy intake from carbohydrates, there was a modest significant direct association between carbohydrates and coronary events (hazard ratio: 1.07; 95% CI: 1.01, 1.14); the hazard ratio for coronary deaths was 0.96 (95% CI: 0.82, 1.13). MUFA intake was not associated with CHD. No effect modification by sex or age was found. CONCLUSION: The associations suggest that replacing SFAs with PUFAs rather than MUFAs or carbohydrates prevents CHD over a wide range of intakes.
U2 - 10.3945/ajcn.2008.27124
DO - 10.3945/ajcn.2008.27124
M3 - Journal article
C2 - 19211817
SN - 0002-9165
VL - 89
SP - 1425
EP - 1432
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 5
ER -