Male-female differences in upregulation of vasoconstrictor responses in human cerebral arteries

Hilda Ahnstedt; Lei Cao; Diana N Krause; Karin Warfvinge; Hans Säveland; Lars Ola Nilsson; Lars Edvinsson

doi:10.1371/journal.pone.0062698

Male-female differences in upregulation of vasoconstrictor responses in human cerebral arteries

Hilda Ahnstedt, Lei Cao, Diana N Krause, Karin Warfvinge, Hans Säveland, Lars Ola Nilsson, Lars Edvinsson

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

29 Citationer (Scopus)

Abstract

Male-female differences may significantly impact stroke prevention and treatment in men and women, however underlying mechanisms for sexual dimorphism in stroke are not understood. We previously found in males that cerebral ischemia upregulates contractile receptors in cerebral arteries, which is associated with lower blood flow. The present study investigates if cerebral arteries from men and women differ in cerebrovascular receptor upregulation.

Originalsprog	Engelsk
Tidsskrift	P L o S One
Vol/bind	8
Udgave nummer	4
Sider (fra-til)	e62698
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0062698
Status	Udgivet - 2013

Adgang til dokumentet

10.1371/journal.pone.0062698

Citationsformater

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AU - Ahnstedt, Hilda

AU - Cao, Lei

AU - Krause, Diana N

AU - Warfvinge, Karin

AU - Säveland, Hans

AU - Nilsson, Lars Ola

AU - Edvinsson, Lars

PY - 2013

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AB - Male-female differences may significantly impact stroke prevention and treatment in men and women, however underlying mechanisms for sexual dimorphism in stroke are not understood. We previously found in males that cerebral ischemia upregulates contractile receptors in cerebral arteries, which is associated with lower blood flow. The present study investigates if cerebral arteries from men and women differ in cerebrovascular receptor upregulation.

U2 - 10.1371/journal.pone.0062698

DO - 10.1371/journal.pone.0062698

M3 - Journal article

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SN - 1932-6203

VL - 8

SP - e62698

JO - P L o S One

JF - P L o S One

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