Mannose-Binding Lectin Deficiency Is Associated with Myocardial Infarction: The HUNT2 Study in Norway

Inga Thorsen Vengen; Hans O Madsen; Peter Garred; Carl Platou; Lars Vatten; Vibeke Videm

doi:10.1371/journal.pone.0042113

Mannose-Binding Lectin Deficiency Is Associated with Myocardial Infarction: The HUNT2 Study in Norway

Inga Thorsen Vengen, Hans O Madsen, Peter Garred, Carl Platou, Lars Vatten, Vibeke Videm

Ph.d.-studienævnet for Medicin

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

46 Citationer (Scopus)

Abstract

Mannose-binding lectin (MBL) and ficolins activate the complement cascade, which is involved in atherogenesis. Based on a pilot study, we hypothesized that functional polymorphisms in the MBL gene (MBL2) leading to dysfunctional protein are related to development of myocardial infarction (MI). The aim of the present study was to study polymorphisms in MBL2 and ficolin genes in relation to the risk of MI.

Originalsprog	Engelsk
Tidsskrift	P L o S One
Vol/bind	7
Udgave nummer	7
Sider (fra-til)	e42113
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0042113
Status	Udgivet - 2012

Adgang til dokumentet

10.1371/journal.pone.0042113

Citationsformater

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AU - Garred, Peter

AU - Platou, Carl

AU - Vatten, Lars

AU - Videm, Vibeke

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AB - Mannose-binding lectin (MBL) and ficolins activate the complement cascade, which is involved in atherogenesis. Based on a pilot study, we hypothesized that functional polymorphisms in the MBL gene (MBL2) leading to dysfunctional protein are related to development of myocardial infarction (MI). The aim of the present study was to study polymorphisms in MBL2 and ficolin genes in relation to the risk of MI.

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DO - 10.1371/journal.pone.0042113

M3 - Journal article

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