Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Acta Pathologica Microbiologica et Immunologica Scandinavica |
| Vol/bind | 117 |
| Udgave nummer | 7 |
| Sider (fra-til) | 518-25 |
| Antal sider | 8 |
| ISSN | 0903-4641 |
| DOI | |
| Status | Udgivet - 2009 |
Bibliografisk note
Keywords: Antibodies, Monoclonal; Bone Neoplasms; Calcium-Binding Proteins; Chondroblastoma; Chondrosarcoma; Chordoma; Cyclooxygenase 2; Glycoproteins; Humans; Immunohistochemistry; Lectins; Microfilament Proteins; Osteonectin; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-kit; Proto-Oncogene Proteins c-mdm2; Retrospective Studies; Tumor Markers, BiologicalTimes Cited: 0ArticleEnglishDaugaard, SRigshosp, Dept Pathol, Blegdamsvej 9, DK-2100 Copenhagen O, DenmarkCited References Count: 27461ZWWILEY-BLACKWELL PUBLISHING, INCCOMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USAMALDEN
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I: Acta Pathologica Microbiologica et Immunologica Scandinavica, Bind 117, Nr. 7, 2009, s. 518-25.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Markers aiding the diagnosis of chondroid tumors: an immunohistochemical study including osteonectin, bcl-2, cox-2, actin, calponin, D2-40 (podoplanin), mdm-2, CD117 (c-kit), and YKL-40
AU - Daugaard, Søren
AU - Christensen, Lise H
AU - Høgdall, Estrid
N1 - Keywords: Antibodies, Monoclonal; Bone Neoplasms; Calcium-Binding Proteins; Chondroblastoma; Chondrosarcoma; Chordoma; Cyclooxygenase 2; Glycoproteins; Humans; Immunohistochemistry; Lectins; Microfilament Proteins; Osteonectin; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-kit; Proto-Oncogene Proteins c-mdm2; Retrospective Studies; Tumor Markers, Biological Times Cited: 0ArticleEnglishDaugaard, SRigshosp, Dept Pathol, Blegdamsvej 9, DK-2100 Copenhagen O, DenmarkCited References Count: 27461ZWWILEY-BLACKWELL PUBLISHING, INCCOMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USAMALDEN
PY - 2009
Y1 - 2009
N2 - Chondroid tumors comprise a heterogenous group of benign to overt malignant neoplasms, which may be difficult to differentiate from one another by histological examination. A group of 43 such tumors was stained with nine relevant antibodies in an attempt to find consistent marker profile(s) for the different subgroups. Archival material from three extraskeletal myxoid chondrosarcomas, five chordomas, five chondromyxoid fibromas, five chondroblastomas and 25 chondrosarcomas was stained with antibodies against osteonectin, bcl-2, cox-2, actin, calponin, D2-40 (podoplanin), mdm-2, CD117 (c-kit) and YKL-40. All 25 chondrosarcomas showed a positive staining reaction for D2-40, none for actin and CD117, and a partial reactivity for bcl-2 (36%). Chondroblastomas (5/5) and chondromyxoid fibromas (2/5) were the only tumors with a positive reaction for actin, and all chondroblastomas (n=5) and extraskeletal myxoid chondrosarcomas (n=3) were positive for bcl-2. In contrast to all other tumors, two of three extraskeletal myxoid chondrosarcomas were also positive for CD17 and negative for osteonectin, cox-2, mdm-2 and actin. All five chordomas were negative for D2-40 and positive for mdm-2 and YKL-40. The diagnosis of chondrosarcoma may be aided by its positivity for D2-40 and YKL-40 and its lack of reactivity for actin and CD117. This should be seen in the light of no reaction for D2-40 in chordomas and a corresponding lack of reaction for osteonectin, cox-2, mdm-2 and actin in extraskeletal myxoid chondrosarcomas. A convincing immunoreactivity for calponin and/or actin in chondromyxoid fibromas and chondroblastomas may also be helpful in differentiating these tumors from chondrosarcomas.
AB - Chondroid tumors comprise a heterogenous group of benign to overt malignant neoplasms, which may be difficult to differentiate from one another by histological examination. A group of 43 such tumors was stained with nine relevant antibodies in an attempt to find consistent marker profile(s) for the different subgroups. Archival material from three extraskeletal myxoid chondrosarcomas, five chordomas, five chondromyxoid fibromas, five chondroblastomas and 25 chondrosarcomas was stained with antibodies against osteonectin, bcl-2, cox-2, actin, calponin, D2-40 (podoplanin), mdm-2, CD117 (c-kit) and YKL-40. All 25 chondrosarcomas showed a positive staining reaction for D2-40, none for actin and CD117, and a partial reactivity for bcl-2 (36%). Chondroblastomas (5/5) and chondromyxoid fibromas (2/5) were the only tumors with a positive reaction for actin, and all chondroblastomas (n=5) and extraskeletal myxoid chondrosarcomas (n=3) were positive for bcl-2. In contrast to all other tumors, two of three extraskeletal myxoid chondrosarcomas were also positive for CD17 and negative for osteonectin, cox-2, mdm-2 and actin. All five chordomas were negative for D2-40 and positive for mdm-2 and YKL-40. The diagnosis of chondrosarcoma may be aided by its positivity for D2-40 and YKL-40 and its lack of reactivity for actin and CD117. This should be seen in the light of no reaction for D2-40 in chordomas and a corresponding lack of reaction for osteonectin, cox-2, mdm-2 and actin in extraskeletal myxoid chondrosarcomas. A convincing immunoreactivity for calponin and/or actin in chondromyxoid fibromas and chondroblastomas may also be helpful in differentiating these tumors from chondrosarcomas.
U2 - 10.1111/j.1600-0463.2009.02461.x
DO - 10.1111/j.1600-0463.2009.02461.x
M3 - Journal article
C2 - 19594492
SN - 0903-4641
VL - 117
SP - 518
EP - 525
JO - Acta Pathologica Microbiologica et Immunologica Scandinavica
JF - Acta Pathologica Microbiologica et Immunologica Scandinavica
IS - 7
ER -