Maternal Diabetes and Cardiac Left Ventricular Structure and Function in the Infant: A Copenhagen Baby Heart Study

Jonas Ghouse, Magdalena Hansson, Ruth Ottilia B. Vøgg, Anne Sophie Sillesen, Sofie Pærregaard, Anna Axelsson Raja, Niels Vejlstrup, Ruth Frikke-Schmidt, Nina Øyen, Aparna Kulkarni, Magnus T. Jensen, Finn Stener Jørgensen, Karin Sundberg, Olav B. Petersen, Jan Wohlfahrt, Peter Damm, Morten Salling Olesen, Elisabeth R. Mathiesen, Kasper Iversen, Henning BundgaardHeather A. Boyd*

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstract

OBJECTIVE Prenatal exposure to maternal diabetes is associated with an increased risk of offspring heart defects. We evaluated associations with subtle infant cardiac changes. RESEARCH DESIGN AND METHODS In a cohort of 25,486 infants with transthoracic echocardiography within 60 days of birth, we investigated associations between maternal preexisting diabetes and gestational diabetes mellitus (GDM) and infant left ventricular (LV) structural and functional parameters, using linear regression to estimate adjusted mean differences (aMDs) between groups. RESULTS Infants exposed to maternal preexisting diabetes (n = 198) had thicker LV posterior walls (aMD 0.19 mm; 95% CI 0.11, 0.27), smaller LV internal diameters in systole (aMD 20.27 mm; 95% CI 20.45, 20.18) and diastole (aMD 20.37 mm; 95% CI 20.59, 20.09), reduced stroke volumes (aMD 20.36 mL; 95% CI 20.61, 20.11), and increased heart rates (aMD 3.14 bpm; 95% CI 1.10, 6.18) and mitral valve early peak velocities (aMD 2.17 cm/s; 95% CI 0.31, 4.04) than unexposed infants (n = 24,639). Infants born to mothers with GDM (n = 649) had significantly smaller LV internal diameters in systole (aMD 20.13 mm; 95% CI 20.22, 20.03) and similar structural and functional changes as children exposed to preexisting diabetes, albeit with smaller nonsignificant aMDs. Higher third-trimester HbA1c levels were associated with smaller LV internal diameters and stroke volumes in infants exposed to preexisting diabetes and with lower heart rates in infants exposed to GDM. CONCLUSIONS Maternal preexisting diabetes and, to a lesser extent, GDM were associated with changes in infant LV structure and function.

OriginalsprogEngelsk
TidsskriftDiabetes Care
Vol/bind47
Udgave nummer12
Sider (fra-til)2230-2238
Antal sider9
ISSN0149-5992
DOI
StatusUdgivet - 2024

Bibliografisk note

Funding Information:
Funding. The CBHS has received financial support from the Danish Heart Association, the Danish Children\u2019s Heart Foundation, Candy\u2019s Foundation, the Toyota Foundation, the Herlev-Gentofte Hospital Research Foundation, and the Gangsted Foundation. O.B.P. holds a professorship funded by Novo Nordisk Foundation (NNFSA1700305769).

Publisher Copyright:
© 2024 by the American Diabetes Association.

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