Abstract
Gestational diabetes mellitus (GDM) adversely affects offspring glucose homeostasis and risk of developing obesity. Here, we examined the association between glycemia in pregnant women with overweight or obesity without GDM and offspring metabolic health. Maternal fasting glucose concentrations and glucose 2-h after an oral glucose tolerance test (OGTT) were measured in 208 women with a pre-pregnancy body mass index (BMI) of 28–45 kg/m2 without GDM. Offspring outcomes were collected at birth, 3, and 5 years of age. Linear mixed models with time as fixed factor and subject ID as random effects were used for analysis. No associations were found between maternal fasting or 2-h glucose concentrations with offspring glucose and insulin concentrations from birth to 5 years of age. However, maternal fasting glucose in GW 28 and 36, and 2-h OGTT glucose in GW 28 were positively associated with C-peptide concentration at birth. Maternal fasting glucose concentrations in GW 28 and 36 were positively associated with weight-for-length, and maternal fasting glucose in GW 36 was associated with BMI z-score at birth. In summary, blood glucose in pregnant women with overweight or obesity is positively associated with offspring C-peptide concentration, weight-for-length, and BMI z-score at birth, even in the absence of GDM.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 21398 |
| Tidsskrift | Scientific Reports |
| Vol/bind | 14 |
| Udgave nummer | 1 |
| Antal sider | 11 |
| ISSN | 2045-2322 |
| DOI | |
| Status | Udgivet - 2024 |
Bibliografisk note
Funding Information:The Novo Nordisk Foundation funded this follow-up study of the offspring, while the APPROACH intervention study received support from The Nordea Foundation, Danish Pork Levy Foundation, Danish Agriculture & Food Council, Danish Dairy Foundation, LEGO Charity, PharmaNord, and Pharmo Vital. The funders played no role in study design, data collection, analysis, interpretation, or manuscript writing.
Funding Information:
We thank all women participating in the study and the agreement for their children to participate in the currently ongoing cohort study. We thank the midwives and doctors at the Department of Pregnancy and Childbirth, Herlev and Gentofte Hospital, clinical dietician Annette Vedelspang, laboratory technician S\u00F8ren Andresen, and ICH-GCP specialist Lene Stevner from the Department of Nutrition, Exercise and Sports, University of Copenhagen for their contributions to the APPROACH study.
Publisher Copyright:
© The Author(s) 2024.