Maternally transmitted antibodies to pregnancy-associated variant antigens on the surface of erythrocytes infected with Plasmodium falciparum: relation to child susceptibility to malaria

Michel Cot; Jean Yves Le Hesran; Trine Staalsoe; Nadine Fievet; Lars Hviid; Philippe Deloron

doi:10.1093/aje/kwf192

Maternally transmitted antibodies to pregnancy-associated variant antigens on the surface of erythrocytes infected with Plasmodium falciparum: relation to child susceptibility to malaria

Michel Cot, Jean Yves Le Hesran, Trine Staalsoe, Nadine Fievet, Lars Hviid, Philippe Deloron

Centre for Medical Parasitology

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

30 Citationer (Scopus)

Abstract

Udgivelsesdato: 2003-Feb-1

Originalsprog	Engelsk
Tidsskrift	American Journal of Epidemiology
Vol/bind	157
Udgave nummer	3
Sider (fra-til)	203-9
Antal sider	6
ISSN	0002-9262
DOI	https://doi.org/10.1093/aje/kwf192
Status	Udgivet - 2003

Bibliografisk note

Keywords: Animals; Antibodies, Protozoan; Antigens, Protozoan; Birth Weight; Cameroon; Cohort Studies; Disease Susceptibility; Erythrocytes; Female; Fetal Blood; Histocompatibility Antigens Class I; Humans; Infant, Newborn; Malaria, Falciparum; Male; Maternal-Fetal Exchange; Plasmodium falciparum; Pregnancy; Pregnancy Proteins

Adgang til dokumentet

10.1093/aje/kwf192

Citationsformater

Maternally transmitted antibodies to pregnancy-associated variant antigens on the surface of erythrocytes infected with Plasmodium falciparum: relation to child susceptibility to malaria. / Cot, Michel; Le Hesran, Jean Yves; Staalsoe, Trine et al.
I: American Journal of Epidemiology, Bind 157, Nr. 3, 2003, s. 203-9.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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title = "Maternally transmitted antibodies to pregnancy-associated variant antigens on the surface of erythrocytes infected with Plasmodium falciparum: relation to child susceptibility to malaria",

abstract = "The consequences of pregnancy-associated malaria on a child's health have been poorly investigated. Malarial infection of the placenta seems to result in a higher susceptibility of children to the parasite during their first year of life. In 1993-1995, the authors investigated the role of antibodies in variable surface antigens (VSA) specific to chondroitin sulfate A (CSA)-binding parasites to assess the parasitologic status of the child. Flow cytometry was used to measure levels of antibodies to VSA from CSA-selected and -unselected parasite lines in the cord blood of 79 newborns in Ebolowa, Cameroon. These newborns were subsequently followed up for 2 years to determine the date of first occurrence of blood parasites and mean parasite density during follow-up. Maternally transmitted antibodies to VSA expressed by CSA-binding parasites, but not antibodies to any other specificity, were negatively related to time of first appearance of Plasmodium falciparum in a child's blood and were positively related to mean parasite density during the first 2 years of life. If maternal infection is thought to be the main mechanism influencing susceptibility of the newborn to malaria, antibodies to VSA may better denote maternal malaria infection during almost the entire pregnancy as opposed to placental blood smear reflecting infection during the last few months of pregnancy.",

author = "Michel Cot and {Le Hesran}, {Jean Yves} and Trine Staalsoe and Nadine Fievet and Lars Hviid and Philippe Deloron",

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AU - Cot, Michel

AU - Le Hesran, Jean Yves

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AU - Fievet, Nadine

AU - Hviid, Lars

AU - Deloron, Philippe

N1 - Keywords: Animals; Antibodies, Protozoan; Antigens, Protozoan; Birth Weight; Cameroon; Cohort Studies; Disease Susceptibility; Erythrocytes; Female; Fetal Blood; Histocompatibility Antigens Class I; Humans; Infant, Newborn; Malaria, Falciparum; Male; Maternal-Fetal Exchange; Plasmodium falciparum; Pregnancy; Pregnancy Proteins

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N2 - The consequences of pregnancy-associated malaria on a child's health have been poorly investigated. Malarial infection of the placenta seems to result in a higher susceptibility of children to the parasite during their first year of life. In 1993-1995, the authors investigated the role of antibodies in variable surface antigens (VSA) specific to chondroitin sulfate A (CSA)-binding parasites to assess the parasitologic status of the child. Flow cytometry was used to measure levels of antibodies to VSA from CSA-selected and -unselected parasite lines in the cord blood of 79 newborns in Ebolowa, Cameroon. These newborns were subsequently followed up for 2 years to determine the date of first occurrence of blood parasites and mean parasite density during follow-up. Maternally transmitted antibodies to VSA expressed by CSA-binding parasites, but not antibodies to any other specificity, were negatively related to time of first appearance of Plasmodium falciparum in a child's blood and were positively related to mean parasite density during the first 2 years of life. If maternal infection is thought to be the main mechanism influencing susceptibility of the newborn to malaria, antibodies to VSA may better denote maternal malaria infection during almost the entire pregnancy as opposed to placental blood smear reflecting infection during the last few months of pregnancy.

AB - The consequences of pregnancy-associated malaria on a child's health have been poorly investigated. Malarial infection of the placenta seems to result in a higher susceptibility of children to the parasite during their first year of life. In 1993-1995, the authors investigated the role of antibodies in variable surface antigens (VSA) specific to chondroitin sulfate A (CSA)-binding parasites to assess the parasitologic status of the child. Flow cytometry was used to measure levels of antibodies to VSA from CSA-selected and -unselected parasite lines in the cord blood of 79 newborns in Ebolowa, Cameroon. These newborns were subsequently followed up for 2 years to determine the date of first occurrence of blood parasites and mean parasite density during follow-up. Maternally transmitted antibodies to VSA expressed by CSA-binding parasites, but not antibodies to any other specificity, were negatively related to time of first appearance of Plasmodium falciparum in a child's blood and were positively related to mean parasite density during the first 2 years of life. If maternal infection is thought to be the main mechanism influencing susceptibility of the newborn to malaria, antibodies to VSA may better denote maternal malaria infection during almost the entire pregnancy as opposed to placental blood smear reflecting infection during the last few months of pregnancy.

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