Matrix metalloproteinase-9-mediated type III collagen degradation as a novel serological biochemical marker for liver fibrogenesis

Sanne S Veidal; Efstathios Vassiliadis; Natasha Barascuk; Chen Zhang; Toni Segovia-Silvestre; Lloyd Klickstein; Martin R Larsen; Per Qvist; Claus Christiansen; Ben Vainer; Morten A Karsdal

doi:10.1111/j.1478-3231.2010.02309.x

Matrix metalloproteinase-9-mediated type III collagen degradation as a novel serological biochemical marker for liver fibrogenesis

Sanne S Veidal, Efstathios Vassiliadis, Natasha Barascuk, Chen Zhang, Toni Segovia-Silvestre, Lloyd Klickstein, Martin R Larsen, Per Qvist, Claus Christiansen, Ben Vainer, Morten A Karsdal

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

64 Citationer (Scopus)

Abstract

During fibrogenesis in the liver, in which excessive remodelling of the extracellular matrix (ECM) occurs, both the quantity of type III collagen (CO3) and levels of matrix metalloproteinases (MMPs), including MMP-9, increase significantly. MMPs play major roles in ECM remodelling, via their activity in the proteolytic degradation of extracellular macromolecules such as collagens, resulting in the generation of specific cleavage fragments. These neo-epitopes may be used as markers of fibrosis.

Originalsprog	Engelsk
Tidsskrift	Liver International
Vol/bind	30
Udgave nummer	9
Sider (fra-til)	1293-304
Antal sider	12
ISSN	1478-3223
DOI	https://doi.org/10.1111/j.1478-3231.2010.02309.x
Status	Udgivet - 1 okt. 2010

Adgang til dokumentet

10.1111/j.1478-3231.2010.02309.x

Citationsformater

Veidal, S. S., Vassiliadis, E., Barascuk, N., Zhang, C., Segovia-Silvestre, T., Klickstein, L., Larsen, M. R., Qvist, P., Christiansen, C., Vainer, B., & Karsdal, M. A. (2010). Matrix metalloproteinase-9-mediated type III collagen degradation as a novel serological biochemical marker for liver fibrogenesis. Liver International, 30(9), 1293-304. https://doi.org/10.1111/j.1478-3231.2010.02309.x

Veidal, SS, Vassiliadis, E, Barascuk, N, Zhang, C, Segovia-Silvestre, T, Klickstein, L, Larsen, MR, Qvist, P, Christiansen, C, Vainer, B & Karsdal, MA 2010, 'Matrix metalloproteinase-9-mediated type III collagen degradation as a novel serological biochemical marker for liver fibrogenesis', Liver International, bind 30, nr. 9, s. 1293-304. https://doi.org/10.1111/j.1478-3231.2010.02309.x

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abstract = "During fibrogenesis in the liver, in which excessive remodelling of the extracellular matrix (ECM) occurs, both the quantity of type III collagen (CO3) and levels of matrix metalloproteinases (MMPs), including MMP-9, increase significantly. MMPs play major roles in ECM remodelling, via their activity in the proteolytic degradation of extracellular macromolecules such as collagens, resulting in the generation of specific cleavage fragments. These neo-epitopes may be used as markers of fibrosis.",

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doi = "10.1111/j.1478-3231.2010.02309.x",

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T1 - Matrix metalloproteinase-9-mediated type III collagen degradation as a novel serological biochemical marker for liver fibrogenesis

AU - Veidal, Sanne S

AU - Vassiliadis, Efstathios

AU - Barascuk, Natasha

AU - Zhang, Chen

AU - Segovia-Silvestre, Toni

AU - Klickstein, Lloyd

AU - Larsen, Martin R

AU - Qvist, Per

AU - Christiansen, Claus

AU - Vainer, Ben

AU - Karsdal, Morten A

PY - 2010/10/1

Y1 - 2010/10/1

N2 - During fibrogenesis in the liver, in which excessive remodelling of the extracellular matrix (ECM) occurs, both the quantity of type III collagen (CO3) and levels of matrix metalloproteinases (MMPs), including MMP-9, increase significantly. MMPs play major roles in ECM remodelling, via their activity in the proteolytic degradation of extracellular macromolecules such as collagens, resulting in the generation of specific cleavage fragments. These neo-epitopes may be used as markers of fibrosis.

AB - During fibrogenesis in the liver, in which excessive remodelling of the extracellular matrix (ECM) occurs, both the quantity of type III collagen (CO3) and levels of matrix metalloproteinases (MMPs), including MMP-9, increase significantly. MMPs play major roles in ECM remodelling, via their activity in the proteolytic degradation of extracellular macromolecules such as collagens, resulting in the generation of specific cleavage fragments. These neo-epitopes may be used as markers of fibrosis.

U2 - 10.1111/j.1478-3231.2010.02309.x

DO - 10.1111/j.1478-3231.2010.02309.x

M3 - Journal article

SN - 1478-3223

VL - 30

SP - 1293

EP - 1304

JO - Liver International

JF - Liver International

IS - 9

ER -