Matrix metalloproteinases during and outside of migraine attacks without aura

M. Ashina; J.F. Tvedskov; Kerstin Lipka Thiesen; J. Bilello; Milena Penkowa; J. Olesen; Kerstin Thiesen; Jes Olesen

doi:10.1111/j.1468-2982.2009.01954.x

Matrix metalloproteinases during and outside of migraine attacks without aura

M. Ashina, J.F. Tvedskov, Kerstin Lipka Thiesen, J. Bilello, Milena Penkowa, J. Olesen, Kerstin Thiesen, Jes Olesen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

33 Citationer (Scopus)

Abstract

Udgivelsesdato: 2009-Jul-13

Originalsprog	Engelsk
Tidsskrift	Cephalalgia
Vol/bind	30
Udgave nummer	3
Sider (fra-til)	303-310
Antal sider	8
ISSN	0333-1024
DOI	https://doi.org/10.1111/j.1468-2982.2009.01954.x https://doi.org/10.1111/j.1468-2982.2009.01954.x
Status	Udgivet - 2010

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Citationsformater

@article{6874b3b0832911de8bc9000ea68e967b,

title = "Matrix metalloproteinases during and outside of migraine attacks without aura",

abstract = "Ashina M, Tvedskov JF, Lipka K, Bilello J, Penkowa M & Olesen J. Matrix metalloproteinases during and outside of migraine attacks without aura. Cephalalgia 2009. London. ISSN 0333-1024To test the hypothesis that permeability of the blood-brain barrier (BBB) is altered during migraine attack due to enhanced activation of matrix metalloproteinases (MMPs), we investigated MMP-3, MMP-9 and tissue inhibitor of metalloproteases (TIMP)-1 in the external jugular vein during and outside of migraine attacks in 21 patients with migraine without aura. In addition, we measured plasma levels of several other proteins including MMP-7, -8, -10 and TIMP-2. We used Rules-Based Medicine multi-analyte profiling and protein array technologies to study plasma concentration of MMPs. There was no difference in MMP-9 and TIMP-1 levels between ictal and interictal periods. We found significantly decreased plasma levels of MMP-3 in the external jugular (P = 0.002) and cubital (P = 0.008) vein during attacks compared with outside of attacks. We found no correlation of ictal or interictal MMP-3, MMP-9 and TIMP-1 to migraine duration and frequency analysed in 21 patients (P > 0.05). There was no difference between ictal and interictal plasma levels of MMP-7, -8, -10 and TIMP-2 (P > 0.05). Our data suggest that plasma MMP-9 cannot be used as a biomarker of BBB disruption in migraine without aura. Decreased MMP-3 levels are an interesting and unexpected finding warranting further investigation.",

author = "M. Ashina and J.F. Tvedskov and Thiesen, {Kerstin Lipka} and J. Bilello and Milena Penkowa and J. Olesen and Kerstin Thiesen and Jes Olesen",

year = "2010",

doi = "10.1111/j.1468-2982.2009.01954.x",

language = "English",

volume = "30",

pages = "303--310",

journal = "Cephalalgia",

issn = "0800-1952",

publisher = "SAGE Publications",

number = "3",

}

TY - JOUR

T1 - Matrix metalloproteinases during and outside of migraine attacks without aura

AU - Ashina, M.

AU - Tvedskov, J.F.

AU - Thiesen, Kerstin Lipka

AU - Bilello, J.

AU - Penkowa, Milena

AU - Olesen, J.

AU - Thiesen, Kerstin

AU - Olesen, Jes

PY - 2010

Y1 - 2010

N2 - Ashina M, Tvedskov JF, Lipka K, Bilello J, Penkowa M & Olesen J. Matrix metalloproteinases during and outside of migraine attacks without aura. Cephalalgia 2009. London. ISSN 0333-1024To test the hypothesis that permeability of the blood-brain barrier (BBB) is altered during migraine attack due to enhanced activation of matrix metalloproteinases (MMPs), we investigated MMP-3, MMP-9 and tissue inhibitor of metalloproteases (TIMP)-1 in the external jugular vein during and outside of migraine attacks in 21 patients with migraine without aura. In addition, we measured plasma levels of several other proteins including MMP-7, -8, -10 and TIMP-2. We used Rules-Based Medicine multi-analyte profiling and protein array technologies to study plasma concentration of MMPs. There was no difference in MMP-9 and TIMP-1 levels between ictal and interictal periods. We found significantly decreased plasma levels of MMP-3 in the external jugular (P = 0.002) and cubital (P = 0.008) vein during attacks compared with outside of attacks. We found no correlation of ictal or interictal MMP-3, MMP-9 and TIMP-1 to migraine duration and frequency analysed in 21 patients (P > 0.05). There was no difference between ictal and interictal plasma levels of MMP-7, -8, -10 and TIMP-2 (P > 0.05). Our data suggest that plasma MMP-9 cannot be used as a biomarker of BBB disruption in migraine without aura. Decreased MMP-3 levels are an interesting and unexpected finding warranting further investigation.

AB - Ashina M, Tvedskov JF, Lipka K, Bilello J, Penkowa M & Olesen J. Matrix metalloproteinases during and outside of migraine attacks without aura. Cephalalgia 2009. London. ISSN 0333-1024To test the hypothesis that permeability of the blood-brain barrier (BBB) is altered during migraine attack due to enhanced activation of matrix metalloproteinases (MMPs), we investigated MMP-3, MMP-9 and tissue inhibitor of metalloproteases (TIMP)-1 in the external jugular vein during and outside of migraine attacks in 21 patients with migraine without aura. In addition, we measured plasma levels of several other proteins including MMP-7, -8, -10 and TIMP-2. We used Rules-Based Medicine multi-analyte profiling and protein array technologies to study plasma concentration of MMPs. There was no difference in MMP-9 and TIMP-1 levels between ictal and interictal periods. We found significantly decreased plasma levels of MMP-3 in the external jugular (P = 0.002) and cubital (P = 0.008) vein during attacks compared with outside of attacks. We found no correlation of ictal or interictal MMP-3, MMP-9 and TIMP-1 to migraine duration and frequency analysed in 21 patients (P > 0.05). There was no difference between ictal and interictal plasma levels of MMP-7, -8, -10 and TIMP-2 (P > 0.05). Our data suggest that plasma MMP-9 cannot be used as a biomarker of BBB disruption in migraine without aura. Decreased MMP-3 levels are an interesting and unexpected finding warranting further investigation.

U2 - 10.1111/j.1468-2982.2009.01954.x

DO - 10.1111/j.1468-2982.2009.01954.x

M3 - Journal article

C2 - 19614693

VL - 30

SP - 303

EP - 310

JO - Cephalalgia

JF - Cephalalgia

SN - 0800-1952

IS - 3

ER -