MCT1 helps brown fat suck up succinate

Jens Lund; Marie Sophie Isidor; Zachary Gerhart-Hines

doi:10.1038/s42255-024-00979-z

MCT1 helps brown fat suck up succinate

Jens Lund^*, Marie Sophie Isidor^*, Zachary Gerhart-Hines^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Letter › Forskning › peer review

Abstract

Succinate can be released from contracting skeletal muscle and accumulate in brown adipose tissue (BAT) to drive thermogenesis and protect against obesity. A study in this issue of Nature Metabolism uncovers the mechanistic underpinnings of BAT succinate sequestration through MCT1-dependent uptake and cytosolic pH changes, thus strengthening the role for cellular shuttling of succinate in the control of systemic energy homeostasis.

Originalsprog	Engelsk
Tidsskrift	Nature Metabolism
Vol/bind	6
Sider (fra-til)	387–388
ISSN	2522-5812
DOI	https://doi.org/10.1038/s42255-024-00979-z
Status	Udgivet - 2024

Bibliografisk note

Funding Information:
J. L. is supported by the BRIDGE – Translational Excellence Programme ( http://bridge.ku.dk/ ) at the Faculty of Health and Medical Sciences, University of Copenhagen, funded by the Novo Nordisk Foundation (NNF20SA0064340). The Novo Nordisk Foundation Center for Basic Metabolic Research is an independent research centre, based at the University of Copenhagen, and partially funded by an unconditional donation from the Novo Nordisk Foundation ( http://cbmr.ku.dk/ ; grant number NNF23SA0084103).

Publisher Copyright:
© Springer Nature Limited 2024.

Adgang til dokumentet

10.1038/s42255-024-00979-z

Citationsformater

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abstract = "Succinate can be released from contracting skeletal muscle and accumulate in brown adipose tissue (BAT) to drive thermogenesis and protect against obesity. A study in this issue of Nature Metabolism uncovers the mechanistic underpinnings of BAT succinate sequestration through MCT1-dependent uptake and cytosolic pH changes, thus strengthening the role for cellular shuttling of succinate in the control of systemic energy homeostasis.",

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AU - Lund, Jens

AU - Isidor, Marie Sophie

AU - Gerhart-Hines, Zachary

N1 - Publisher Copyright: © Springer Nature Limited 2024.

PY - 2024

Y1 - 2024

N2 - Succinate can be released from contracting skeletal muscle and accumulate in brown adipose tissue (BAT) to drive thermogenesis and protect against obesity. A study in this issue of Nature Metabolism uncovers the mechanistic underpinnings of BAT succinate sequestration through MCT1-dependent uptake and cytosolic pH changes, thus strengthening the role for cellular shuttling of succinate in the control of systemic energy homeostasis.

AB - Succinate can be released from contracting skeletal muscle and accumulate in brown adipose tissue (BAT) to drive thermogenesis and protect against obesity. A study in this issue of Nature Metabolism uncovers the mechanistic underpinnings of BAT succinate sequestration through MCT1-dependent uptake and cytosolic pH changes, thus strengthening the role for cellular shuttling of succinate in the control of systemic energy homeostasis.

U2 - 10.1038/s42255-024-00979-z

DO - 10.1038/s42255-024-00979-z

M3 - Letter

C2 - 38378995

AN - SCOPUS:85185932267

VL - 6

SP - 387

EP - 388

JO - Nature Metabolism

JF - Nature Metabolism

SN - 2522-5812

ER -