Melt extrusion and spray drying of carbamazepine and dipyridamole with polyvinylpyrrolidone/vinyl acetate copolymers

James E Patterson; Michael B James; Angus H Forster; Thomas Rades

doi:10.1080/03639040701484627

Melt extrusion and spray drying of carbamazepine and dipyridamole with polyvinylpyrrolidone/vinyl acetate copolymers

James E Patterson, Michael B James, Angus H Forster, Thomas Rades

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

49 Citationer (Scopus)

Abstract

Carbamazepine and dipyridamole are class II compounds (BCS) whose oral bioavailability is limited by poor solubility. The use of glass solutions to improve the bioavailability of this class of compound has been an area of research for a number of years. The influence of polymer parameters (Tg, hydrophilicity, solubility parameter, and ability to hydrogen bond) on glass solution properties is investigated.

Originalsprog	Engelsk
Tidsskrift	Drug Development and Industrial Pharmacy
Vol/bind	34
Udgave nummer	1
Sider (fra-til)	95-106
Antal sider	12
ISSN	0363-9045
DOI	https://doi.org/10.1080/03639040701484627
Status	Udgivet - 2008
Udgivet eksternt	Ja

Adgang til dokumentet

10.1080/03639040701484627

Citationsformater

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title = "Melt extrusion and spray drying of carbamazepine and dipyridamole with polyvinylpyrrolidone/vinyl acetate copolymers",

abstract = "Carbamazepine and dipyridamole are class II compounds (BCS) whose oral bioavailability is limited by poor solubility. The use of glass solutions to improve the bioavailability of this class of compound has been an area of research for a number of years. The influence of polymer parameters (Tg, hydrophilicity, solubility parameter, and ability to hydrogen bond) on glass solution properties is investigated.",

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AU - Forster, Angus H

AU - Rades, Thomas

PY - 2008

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AB - Carbamazepine and dipyridamole are class II compounds (BCS) whose oral bioavailability is limited by poor solubility. The use of glass solutions to improve the bioavailability of this class of compound has been an area of research for a number of years. The influence of polymer parameters (Tg, hydrophilicity, solubility parameter, and ability to hydrogen bond) on glass solution properties is investigated.

U2 - 10.1080/03639040701484627

DO - 10.1080/03639040701484627

M3 - Journal article

C2 - 18214761

SN - 0363-9045

VL - 34

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JO - Drug Development and Industrial Pharmacy

JF - Drug Development and Industrial Pharmacy

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