Menopausal transition does not influence skeletal muscle capillary growth in response to cycle training in women

Jorge Pérez-Gómez, Nicolai Rytter, Camilla M Mandrup, Jon Egelund, Bente Stallknecht, Michael Nyberg, Ylva Hellsten*

*Corresponding author af dette arbejde

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Abstract

The influence of the menopausal transition, with a consequent loss of estrogen, on capillary growth in response to exercise training remains unknown. In the present study, we evaluated the effect of a period of intense endurance training on skeletal muscle angiogenesis in late premenopausal and recent postmenopausal women with an age difference of <4 yr. Skeletal muscle
biopsies were obtained from the thigh muscle before and after 12 wk of intense aerobic cycle training and analyzed for capillarization, fiber-type distribution, and content of vascular endothelial growth factor (VEGF). At baseline, there was no difference in capillary per fiber ratio (C:F; 1.41 ± 0.22 vs. 1.40 ± 0.30), capillary density (CD; 305 ± 61 vs. 336 ± 52 mm2), muscle fiber area (MFA; 4,889 ± 1,868 vs. 4,195 ± 749), or distribution of muscle fiber type I (47.3% ± 10.1% vs. 49.3% ± 15.1%), between the pre- and postmenopausal women, respectively. There was a main effect of training on the C:F ratio (+9.2% and +12.1%, for the pre- and postmenopausal women, respectively) and the CD (+6.9% and +8.9%, for the pre- and postmenopausal women, respectively). MFA and fiber-type distribution were unaltered by training. Skeletal muscle VEGF protein content was similar between groups at baseline, and there was a main effect of training (+21.1% and +27.2%, for the pre- and postmenopausal women, respectively). In conclusion, the loss of estrogen per se at menopause does not influence the capillary growth response to intense aerobic exercise training.
OriginalsprogEngelsk
TidsskriftJournal of Applied Physiology
Vol/bind131
Udgave nummer1
Sider (fra-til)369-375
Antal sider7
ISSN8750-7587
DOI
StatusUdgivet - 2021

Bibliografisk note

CURIS 2021 NEXS 250

Emneord

  • Det Natur- og Biovidenskabelige Fakultet

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