@article{791f4b60832b11de8bc9000ea68e967b,
title = "Metallothionein-I overexpression decreases brain pathology in transgenic mice with astrocyte-targeted expression of interleukin-6",
abstract = "Transgenic expression of interleukin-6 (IL-6) in the CNS under the control of the glial fibrillary acidic protein (GFAP) gene promoter (GFAP-IL6 mice) causes significant damage and alters the expression of many genes, including a dramatic upregulation of metallothionein-I (MT-I). The findings in this report support the idea that the upregulation of MT-I observed in GFAP-IL6 mice is an important mechanism for coping with brain damage. Thus, GFAP-IL6 mice that were crossed with TgMTI transgenic mice (GFAP-IL6xTgMTI) and overexpressed MT-I in the brain showed a decreased upregulation of cytokines such as IL-6 and a diminished recruitment and activation of macrophages and T cells throughout the CNS but mainly in the cerebellum. The GFAP-IL6 mice showed clear evidence of increased oxidative stress, which was significantly decreased by MT-I overexpression. Interestingly, MT-I overexpression increased angiogenesis in GFAP-IL6 mice but not in control littermates. Overall, the results strongly suggest that MT-I+II proteins are valuable factors that protect against cytokine-induced CNS injury.",
author = "Amalia Molinero and Milena Penkowa and Joaqu{\'i}n Hern{\'a}ndez and Jordi Camats and Mercedes Giralt and Natalia Lago and Javier Carrasco and Campbell, {Iain L} and Juan Hidalgo",
note = "Keywords: Animals; Astrocytes; Brain; Female; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Interleukin-6; Male; Metallothionein; Mice; Mice, Inbred C57BL; Mice, Transgenic; Up-Regulation",
year = "2003",
language = "English",
volume = "62",
pages = "315--28",
journal = "Journal of Neuropathology and Experimental Neurology",
issn = "0022-3069",
publisher = "Oxford University Press",
number = "3",
}