Microbial tryptophan catabolites in health and disease

Henrik Munch Roager, Tine Rask Licht

Publikation: Bidrag til tidsskriftReviewForskningpeer review

1209 Citationer (Scopus)
267 Downloads (Pure)

Abstract

Accumulating evidence implicates metabolites produced by gut microbes as crucial mediators of diet-induced host-microbial cross-talk. Here, we review emerging data suggesting that microbial tryptophan catabolites resulting from proteolysis are influencing host health. These metabolites are suggested to activate the immune system through binding to the aryl hydrocarbon receptor (AHR), enhance the intestinal epithelial barrier, stimulate gastrointestinal motility, as well as secretion of gut hormones, exert anti-inflammatory, antioxidative or toxic effects in systemic circulation, and putatively modulate gut microbial composition. Tryptophan catabolites thus affect various physiological processes and may contribute to intestinal and systemic homeostasis in health and disease.
OriginalsprogEngelsk
Artikelnummer3294
TidsskriftNature Communications
Vol/bind9
Antal sider10
ISSN2041-1723
DOI
StatusUdgivet - 2018

Bibliografisk note

CURIS 2018 NEXS 300

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