microRNA-146a inhibits G protein-coupled receptor-mediated activation of NF-κB by targeting CARD10 and COPS8 in gastric cancer

Stephanie Geisler Crone; Anders Jacobsen; Birgitte Federspiel; Linda Bardram; Anders Krogh; Anders H. Lund; Lennart Friis-Hansen

doi:10.1186/1476-4598-11-71

microRNA-146a inhibits G protein-coupled receptor-mediated activation of NF-κB by targeting CARD10 and COPS8 in gastric cancer

Stephanie Geisler Crone, Anders Jacobsen, Birgitte Federspiel, Linda Bardram, Anders Krogh, Anders H. Lund, Lennart Friis-Hansen

Bioinformatik og RNA Biologi

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

96 Citationer (Scopus)

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Abstract

Gastric cancer is the second most common cause of cancer-related death in the world. Inflammatory signals originating from gastric cancer cells are important for recruiting inflammatory cells and regulation of metastasis of gastric cancer. Several microRNAs (miRNA) have been shown to be involved in development and progression of gastric cancer. miRNA-146a (miR-146a) is a modulator of inflammatory signals, but little is known about its importance in gastric cancer. We therefore wanted to identify targets of miR-146a in gastric cancer and examine its biological roles.

Originalsprog	Engelsk
Tidsskrift	Molecular Cancer
Vol/bind	11
Udgave nummer	71
Sider (fra-til)	71
Antal sider	31
ISSN	1476-4598
DOI	https://doi.org/10.1186/1476-4598-11-71
Status	Udgivet - 2012

Adgang til dokumentet

10.1186/1476-4598-11-71

microRNA-146a inhibits G protein-coupled receptor-mediated activation of NF-kappaB by targeting CARD10 and COPS8 in gastric cancerForlagets udgivne version, 2,59 MB

Citationsformater

microRNA-146a inhibits G protein-coupled receptor-mediated activation of NF-κB by targeting CARD10 and COPS8 in gastric cancer. / Crone, Stephanie Geisler; Jacobsen, Anders; Federspiel, Birgitte; Bardram, Linda; Krogh, Anders ; Lund, Anders H.; Friis-Hansen, Lennart.

I: Molecular Cancer, Bind 11, Nr. 71, 2012, s. 71.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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title = "microRNA-146a inhibits G protein-coupled receptor-mediated activation of NF-κB by targeting CARD10 and COPS8 in gastric cancer",

abstract = "Gastric cancer is the second most common cause of cancer-related death in the world. Inflammatory signals originating from gastric cancer cells are important for recruiting inflammatory cells and regulation of metastasis of gastric cancer. Several microRNAs (miRNA) have been shown to be involved in development and progression of gastric cancer. miRNA-146a (miR-146a) is a modulator of inflammatory signals, but little is known about its importance in gastric cancer. We therefore wanted to identify targets of miR-146a in gastric cancer and examine its biological roles.",

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AU - Crone, Stephanie Geisler

AU - Jacobsen, Anders

AU - Federspiel, Birgitte

AU - Bardram, Linda

AU - Krogh, Anders

AU - Lund, Anders H.

AU - Friis-Hansen, Lennart

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N2 - Gastric cancer is the second most common cause of cancer-related death in the world. Inflammatory signals originating from gastric cancer cells are important for recruiting inflammatory cells and regulation of metastasis of gastric cancer. Several microRNAs (miRNA) have been shown to be involved in development and progression of gastric cancer. miRNA-146a (miR-146a) is a modulator of inflammatory signals, but little is known about its importance in gastric cancer. We therefore wanted to identify targets of miR-146a in gastric cancer and examine its biological roles.

AB - Gastric cancer is the second most common cause of cancer-related death in the world. Inflammatory signals originating from gastric cancer cells are important for recruiting inflammatory cells and regulation of metastasis of gastric cancer. Several microRNAs (miRNA) have been shown to be involved in development and progression of gastric cancer. miRNA-146a (miR-146a) is a modulator of inflammatory signals, but little is known about its importance in gastric cancer. We therefore wanted to identify targets of miR-146a in gastric cancer and examine its biological roles.

KW - Animals

KW - CARD Signaling Adaptor Proteins

KW - Cell Line, Tumor

KW - Cytokines

KW - Disease Models, Animal

KW - Enzyme Activation

KW - Gene Expression Regulation, Neoplastic

KW - Humans

KW - Mice

KW - Mice, Knockout

KW - MicroRNAs

KW - Monocytes

KW - NF-kappa B

KW - Proteins

KW - Receptors, G-Protein-Coupled

KW - Signal Transduction

KW - Stomach Neoplasms

U2 - 10.1186/1476-4598-11-71

DO - 10.1186/1476-4598-11-71

M3 - Journal article

C2 - 22992343

VL - 11

SP - 71

JO - Molecular Cancer

JF - Molecular Cancer

SN - 1476-4598

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