@article{20240600526111dd8d9f000ea68e967b,
title = "miR-200b mediates post-transcriptional repression of ZFHX1B.",
abstract = "MicroRNAs have important functions during animal development and homeostasis through post-transcriptional regulation of their cognate mRNA targets. ZFHX1B is a transcriptional repressor involved in the TGFbeta signaling pathway and in processes of epithelial to mesenchymal transition via regulation of E-cadherin. We show that Zfhx1b and miR-200b are regionally coexpressed in the adult mouse brain and that miR-200b represses the expression of Zfhx1b via multiple sequence elements present in the 3'-untranslated region. Overexpression of miR-200b leads to repression of endogenous ZFHX1B, and inhibition of miR-200b relieves the repression of ZFHX1B. In accordance with these findings, miR-200b regulates the activity of the E-cadherin promoter.",
author = "Christoffersen, {Nanna R{\o}nbjerg} and Asli Silahtaroglu and {\O}rom, {Ulf Lupo Andersson} and Kauppinen, {Markus Sakari} and Lund, {Anders H}",
note = "Keywords: 3' Untranslated Regions; Animals; Cadherins; Cell Line; Homeodomain Proteins; Mice; MicroRNAs; Promoter Regions (Genetics); RNA Interference; Repressor Proteins",
year = "2007",
doi = "10.1261/rna.586807",
language = "English",
volume = "13",
pages = "1172--8",
journal = "RNA: A publication of the RNA Society",
issn = "1355-8382",
publisher = "Cold Spring Harbor Laboratory Press",
number = "8",
}