Misonidazole Neuropathy: a clinical, electrophysiological, and histological study

B Melgaard; H S Hansen; Z Kamieniecka; O B Paulson; A G Pedersen; X Tang; Werner Trojaborg

doi:10.1002/ana.410120103

Misonidazole Neuropathy: a clinical, electrophysiological, and histological study

B Melgaard, H S Hansen, Z Kamieniecka, O B Paulson, A G Pedersen, X Tang, Werner Trojaborg

IKM

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

16 Citationer (Scopus)

Abstract

We studied eight patients with carcinoma of the pharynx and larynx (five cases) or lungs (three cases) who, during treatment with the radiosensitizing drug misonidazole, developed peripheral neuropathy dominated by severe sensory symptoms and signs mainly localized to the lower extremities. The symptoms partially subsided within months after cessation of therapy. Electrophysiological and histological findings indicated an axonal neuropathy with loss of large fibers and secondary demyelination. The neurotoxic property of misonidazole limits its therapeutic use.

Originalsprog	Engelsk
Tidsskrift	Annals of Neurology
Vol/bind	12
Udgave nummer	1
Sider (fra-til)	10-7
Antal sider	8
ISSN	0364-5134
DOI	https://doi.org/10.1002/ana.410120103
Status	Udgivet - jul. 1982

Adgang til dokumentet

10.1002/ana.410120103

Citationsformater

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title = "Misonidazole Neuropathy: a clinical, electrophysiological, and histological study",

abstract = "We studied eight patients with carcinoma of the pharynx and larynx (five cases) or lungs (three cases) who, during treatment with the radiosensitizing drug misonidazole, developed peripheral neuropathy dominated by severe sensory symptoms and signs mainly localized to the lower extremities. The symptoms partially subsided within months after cessation of therapy. Electrophysiological and histological findings indicated an axonal neuropathy with loss of large fibers and secondary demyelination. The neurotoxic property of misonidazole limits its therapeutic use.",

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author = "B Melgaard and Hansen, {H S} and Z Kamieniecka and Paulson, {O B} and Pedersen, {A G} and X Tang and Werner Trojaborg",

year = "1982",

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TY - JOUR

T1 - Misonidazole Neuropathy

T2 - a clinical, electrophysiological, and histological study

AU - Melgaard, B

AU - Hansen, H S

AU - Kamieniecka, Z

AU - Paulson, O B

AU - Pedersen, A G

AU - Tang, X

AU - Trojaborg, Werner

PY - 1982/7

Y1 - 1982/7

N2 - We studied eight patients with carcinoma of the pharynx and larynx (five cases) or lungs (three cases) who, during treatment with the radiosensitizing drug misonidazole, developed peripheral neuropathy dominated by severe sensory symptoms and signs mainly localized to the lower extremities. The symptoms partially subsided within months after cessation of therapy. Electrophysiological and histological findings indicated an axonal neuropathy with loss of large fibers and secondary demyelination. The neurotoxic property of misonidazole limits its therapeutic use.

AB - We studied eight patients with carcinoma of the pharynx and larynx (five cases) or lungs (three cases) who, during treatment with the radiosensitizing drug misonidazole, developed peripheral neuropathy dominated by severe sensory symptoms and signs mainly localized to the lower extremities. The symptoms partially subsided within months after cessation of therapy. Electrophysiological and histological findings indicated an axonal neuropathy with loss of large fibers and secondary demyelination. The neurotoxic property of misonidazole limits its therapeutic use.

KW - Aged

KW - Carcinoma, Squamous Cell/therapy

KW - Electromyography

KW - Female

KW - Humans

KW - Laryngeal Neoplasms/therapy

KW - Lung Neoplasms/therapy

KW - Male

KW - Median Nerve/drug effects

KW - Middle Aged

KW - Misonidazole/administration & dosage

KW - Nerve Fibers, Myelinated/drug effects

KW - Nervous System Diseases/chemically induced

KW - Neural Conduction/drug effects

KW - Neuromuscular Diseases/chemically induced

KW - Nitroimidazoles/adverse effects

KW - Paresthesia/chemically induced

KW - Peroneal Nerve/drug effects

KW - Pharyngeal Neoplasms/therapy

KW - Sensation/drug effects

KW - Sural Nerve/drug effects

KW - Tibial Nerve/drug effects

U2 - 10.1002/ana.410120103

DO - 10.1002/ana.410120103

M3 - Journal article

C2 - 7114817

VL - 12

SP - 10

EP - 17

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 1

ER -