@article{743bcdb0664011de8bc9000ea68e967b,
title = "Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations",
abstract = "The parkin protein functions as a RING-type ubiquitin protein ligase. Considering the possibility that impaired ubiquitin-proteosomal system activity may impair antioxidant defenses and enhance oxidative stress, we have investigated the activity of mitochondrial respiratory enzymes in patients with parkin gene mutations. A significant decrease in the leukocyte complex I activity was found both in patients with parkin mutations (62.5%) and idiopathic PD (64.5%) compared with age-matched controls (P < 0.001). Complex IV activity was also decreased significantly in idiopathic PD patients (60%), but no difference was detected between controls and patients with parkin mutations.",
author = "Meltem M{\"u}ft{\"u}oglu and B{\"u}lent Elibol and Ozlem Dalmizrak and Ayse Ercan and G{\"u}lnihal Kulaksiz and Hamdi Og{\"u}s and Turgay Dalkara and Nazmi Ozer",
note = "Keywords: Adult; Electron Transport Complex I; Electron Transport Complex IV; Exons; Female; Humans; Leukocytes; Male; Middle Aged; Parkinson Disease; Point Mutation; Ubiquitin-Protein Ligases",
year = "2004",
doi = "10.1002/mds.10695",
language = "English",
volume = "19",
pages = "544--8",
journal = "Movement Disorders",
issn = "0885-3185",
publisher = "JohnWiley & Sons, Inc.",
number = "5",
}