Mitochondrial dysfunction in acute and post-acute phases of COVID-19 and risk of non-communicable diseases

Helena Borland Madsen; Jon Ambæk Durhuus; Ove Andersen; Per thor Straten; Anne Rahbech; Claus Desler

doi:10.1038/s44324-024-00038-x

Mitochondrial dysfunction in acute and post-acute phases of COVID-19 and risk of non-communicable diseases

Helena Borland Madsen, Jon Ambæk Durhuus, Ove Andersen, Per thor Straten, Anne Rahbech, Claus Desler

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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Abstract

The COVID-19 pandemic, caused by SARS-CoV-2, has resulted in widespread morbidity and mortality, with a significant portion of the affected population experiencing long-term health complications. This review explores the mechanisms of mitochondrial dysfunction in both the acute and post-acute phases of COVID-19, highlighting its impact on various organs and its potential role in the development of non-communicable diseases (NCDs). We discuss how SARS-CoV-2 directly affects mitochondrial function and the role of the virus-induced immune response in exacerbating mitochondrial impairment. This review highlights the critical role of mitochondria in COVID-19 pathogenesis and the importance of addressing mitochondrial health to mitigate acute and chronic effects of the disease.

Originalsprog	Engelsk
Artikelnummer	36
Tidsskrift	npj metabolic health and disease
Vol/bind	2
Antal sider	8
ISSN	2948-2828
DOI	https://doi.org/10.1038/s44324-024-00038-x
Status	Udgivet - 2024

Adgang til dokumentet

10.1038/s44324-024-00038-xLicens: CC BY

FulltextForlagets udgivne version, 649 KBLicens: CC BY

Citationsformater

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T1 - Mitochondrial dysfunction in acute and post-acute phases of COVID-19 and risk of non-communicable diseases

AU - Madsen, Helena Borland

AU - Durhuus, Jon Ambæk

AU - Andersen, Ove

AU - thor Straten, Per

AU - Rahbech, Anne

AU - Desler, Claus

PY - 2024

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N2 - The COVID-19 pandemic, caused by SARS-CoV-2, has resulted in widespread morbidity and mortality, with a significant portion of the affected population experiencing long-term health complications. This review explores the mechanisms of mitochondrial dysfunction in both the acute and post-acute phases of COVID-19, highlighting its impact on various organs and its potential role in the development of non-communicable diseases (NCDs). We discuss how SARS-CoV-2 directly affects mitochondrial function and the role of the virus-induced immune response in exacerbating mitochondrial impairment. This review highlights the critical role of mitochondria in COVID-19 pathogenesis and the importance of addressing mitochondrial health to mitigate acute and chronic effects of the disease.

AB - The COVID-19 pandemic, caused by SARS-CoV-2, has resulted in widespread morbidity and mortality, with a significant portion of the affected population experiencing long-term health complications. This review explores the mechanisms of mitochondrial dysfunction in both the acute and post-acute phases of COVID-19, highlighting its impact on various organs and its potential role in the development of non-communicable diseases (NCDs). We discuss how SARS-CoV-2 directly affects mitochondrial function and the role of the virus-induced immune response in exacerbating mitochondrial impairment. This review highlights the critical role of mitochondria in COVID-19 pathogenesis and the importance of addressing mitochondrial health to mitigate acute and chronic effects of the disease.

U2 - 10.1038/s44324-024-00038-x

DO - 10.1038/s44324-024-00038-x

M3 - Journal article

SN - 2948-2828

VL - 2

JO - npj metabolic health and disease

JF - npj metabolic health and disease

M1 - 36

ER -