Modifications of the alpha,beta-double bond in chalcones only marginally affect the antiprotozoal activities

S F Nielsen; A Kharazmi; S B Christensen

Modifications of the alpha,beta-double bond in chalcones only marginally affect the antiprotozoal activities

S F Nielsen, A Kharazmi, S B Christensen

Centre for Medical Parasitology

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

52 Citationer (Scopus)

Abstract

Udgivelsesdato: 1998-Jul

Originalsprog	Engelsk
Tidsskrift	Bioorganic & Medicinal Chemistry
Vol/bind	6
Udgave nummer	7
Sider (fra-til)	937-45
Antal sider	8
ISSN	0968-0896
Status	Udgivet - 1998

Bibliografisk note

Keywords: Animals; Antimalarials; Chalcone; Erythrocytes; Leishmania major; Plasmodium falciparum; Structure-Activity Relationship; Trypanocidal Agents

Citationsformater

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title = "Modifications of the alpha,beta-double bond in chalcones only marginally affect the antiprotozoal activities",

abstract = "Methods for selective alkylation of chalcones in the alpha- or beta-position and for selective reduction of the alpha,beta-double bond have been developed. The antiparasitic potencies of the alpha,beta-double bond modified chalcones only differ marginally from the potencies of the parent chalcones indicating that the propenone residue only functions as a spacer between the two benzene rings, which are the true pharmacophore.",

author = "Nielsen, {S F} and A Kharazmi and Christensen, {S B}",

note = "Keywords: Animals; Antimalarials; Chalcone; Erythrocytes; Leishmania major; Plasmodium falciparum; Structure-Activity Relationship; Trypanocidal Agents",

year = "1998",

language = "English",

volume = "6",

pages = "937--45",

journal = "Bioorganic & Medicinal Chemistry",

issn = "0968-0896",

publisher = "Pergamon Press",

number = "7",

}

TY - JOUR

T1 - Modifications of the alpha,beta-double bond in chalcones only marginally affect the antiprotozoal activities

AU - Nielsen, S F

AU - Kharazmi, A

AU - Christensen, S B

N1 - Keywords: Animals; Antimalarials; Chalcone; Erythrocytes; Leishmania major; Plasmodium falciparum; Structure-Activity Relationship; Trypanocidal Agents

PY - 1998

Y1 - 1998

N2 - Methods for selective alkylation of chalcones in the alpha- or beta-position and for selective reduction of the alpha,beta-double bond have been developed. The antiparasitic potencies of the alpha,beta-double bond modified chalcones only differ marginally from the potencies of the parent chalcones indicating that the propenone residue only functions as a spacer between the two benzene rings, which are the true pharmacophore.

AB - Methods for selective alkylation of chalcones in the alpha- or beta-position and for selective reduction of the alpha,beta-double bond have been developed. The antiparasitic potencies of the alpha,beta-double bond modified chalcones only differ marginally from the potencies of the parent chalcones indicating that the propenone residue only functions as a spacer between the two benzene rings, which are the true pharmacophore.

M3 - Journal article

C2 - 9730229

VL - 6

SP - 937

EP - 945

JO - Bioorganic & Medicinal Chemistry

JF - Bioorganic & Medicinal Chemistry

SN - 0968-0896

IS - 7

ER -