TY - JOUR
T1 - Molecular Imaging with Small Animal PET/CT
AU - Binderup, T.
AU - El-Ali, H.H.
AU - Skovgaard, D.
AU - Jensen, M.M.
AU - Li, Fan
AU - Hesse, B.
AU - Jørgensen, J.T.
AU - Kjær, A.
AU - Ambrosini, V.
AU - Binderup, Tina
AU - El Ali, Henrik H.
AU - Ambrosini, Valentina
AU - Skovgaard, Dorthe
AU - Munk Jensen, Mette
AU - Li, Fan
AU - Hesse, Birger
AU - Jørgensen, Jesper Tranekjær
AU - Kjær, Andreas
PY - 2011
Y1 - 2011
N2 - Small animal positron emission tomography (PET) and computer tomography (CT) is an emerging field in pre-clinical imaging. High quality, state-of-the-art instruments are required for full optimization of the translational value of the small animal studies with PET and CT. However, with this achieved the possibilities are numerous and the role of pre-clinical imaging crucial for a prompt movement from bench to bedside. Several new tracers are under preclinical and clinical evaluation and most are directed at central aspects of tumor biology. We hereby present some of the recent advances in this field of small animal molecular imaging with special emphasis on the targets for tissue characterization in tumor biology such as hypoxia, proliferation and cancer specific over-expression of receptors. The added value of applying CT imaging for anatomical localization and tumor volume measurements is also described. In addition, the non-invasive nature of molecular imaging and the targets of these promising new tracers are attractive for other research areas as well, although these fields are much less explored. We present an example of an interesting research field with the application of small animal PET/CT for studies of muscle and tendon in exercise models. © 2011 Bentham Science Publishers Ltd.
AB - Small animal positron emission tomography (PET) and computer tomography (CT) is an emerging field in pre-clinical imaging. High quality, state-of-the-art instruments are required for full optimization of the translational value of the small animal studies with PET and CT. However, with this achieved the possibilities are numerous and the role of pre-clinical imaging crucial for a prompt movement from bench to bedside. Several new tracers are under preclinical and clinical evaluation and most are directed at central aspects of tumor biology. We hereby present some of the recent advances in this field of small animal molecular imaging with special emphasis on the targets for tissue characterization in tumor biology such as hypoxia, proliferation and cancer specific over-expression of receptors. The added value of applying CT imaging for anatomical localization and tumor volume measurements is also described. In addition, the non-invasive nature of molecular imaging and the targets of these promising new tracers are attractive for other research areas as well, although these fields are much less explored. We present an example of an interesting research field with the application of small animal PET/CT for studies of muscle and tendon in exercise models. © 2011 Bentham Science Publishers Ltd.
UR - http://www.scopus.com/inward/record.url?scp=79961047382&partnerID=8YFLogxK
U2 - 10.2174/157340511796411221
DO - 10.2174/157340511796411221
M3 - Journal article
VL - 7
SP - 234
EP - 247
JO - Current Medical Imaging
JF - Current Medical Imaging
SN - 1573-4056
IS - 3
ER -