Monocyte Activation, but not Microbial Translocation, Is Independently Associated With Markers of Endovascular Dysfunction in HIV-Infected Patients Receiving cART

Karin K Pedersen; Ingjerd W Manner; Ingebjørg Seljeflot; Dag Kvale; Ingrid Os; Jan Gerstoft; Susanne D Nielsen; Marius Trøseid

doi:10.1097/QAI.0000000000000339

Monocyte Activation, but not Microbial Translocation, Is Independently Associated With Markers of Endovascular Dysfunction in HIV-Infected Patients Receiving cART

Karin K Pedersen, Ingjerd W Manner, Ingebjørg Seljeflot, Dag Kvale, Ingrid Os, Jan Gerstoft, Susanne D Nielsen, Marius Trøseid

IKM

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

14 Citationer (Scopus)

Abstract

BACKGROUND: Microbial translocation has been suggested as a driver of cardiovascular disease in HIV infection. We hypothesized that microbial translocation and the resulting monocyte activation would be associated with markers of endovascular dysfunction.

METHODS: In 60 HIV-infected patients on combination antiretroviral therapy, plasma levels of lipopolysaccharide, soluble CD14 (sCD14), asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) were measured.

RESULTS: ADMA and SDMA were associated with sCD14 but not lipopolysaccharide. There was a significant increase in ADMA and SDMA through tertiles of sCD14, and both markers were associated with sCD14 in multivariate linear regression analyses.

CONCLUSIONS: Monocyte activation as measured by sCD14 is associated with endovascular dysfunction in HIV infection.

Originalsprog	Engelsk
Tidsskrift	Journal of acquired immune deficiency syndromes (1999)
Vol/bind	67
Udgave nummer	4
Sider (fra-til)	370-4
Antal sider	5
ISSN	1525-4135
DOI	https://doi.org/10.1097/QAI.0000000000000339
Status	Udgivet - 1 dec. 2014

Adgang til dokumentet

10.1097/QAI.0000000000000339

Citationsformater

Pedersen, K. K., Manner, I. W., Seljeflot, I., Kvale, D., Os, I., Gerstoft, J., Nielsen, S. D., & Trøseid, M. (2014). Monocyte Activation, but not Microbial Translocation, Is Independently Associated With Markers of Endovascular Dysfunction in HIV-Infected Patients Receiving cART. Journal of acquired immune deficiency syndromes (1999), 67(4), 370-4. https://doi.org/10.1097/QAI.0000000000000339

Monocyte Activation, but not Microbial Translocation, Is Independently Associated With Markers of Endovascular Dysfunction in HIV-Infected Patients Receiving cART. / Pedersen, Karin K; Manner, Ingjerd W; Seljeflot, Ingebjørg et al.
I: Journal of acquired immune deficiency syndromes (1999), Bind 67, Nr. 4, 01.12.2014, s. 370-4.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Pedersen, KK, Manner, IW, Seljeflot, I, Kvale, D, Os, I, Gerstoft, J, Nielsen, SD & Trøseid, M 2014, 'Monocyte Activation, but not Microbial Translocation, Is Independently Associated With Markers of Endovascular Dysfunction in HIV-Infected Patients Receiving cART', Journal of acquired immune deficiency syndromes (1999), bind 67, nr. 4, s. 370-4. https://doi.org/10.1097/QAI.0000000000000339

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title = "Monocyte Activation, but not Microbial Translocation, Is Independently Associated With Markers of Endovascular Dysfunction in HIV-Infected Patients Receiving cART",

abstract = "BACKGROUND: Microbial translocation has been suggested as a driver of cardiovascular disease in HIV infection. We hypothesized that microbial translocation and the resulting monocyte activation would be associated with markers of endovascular dysfunction.METHODS: In 60 HIV-infected patients on combination antiretroviral therapy, plasma levels of lipopolysaccharide, soluble CD14 (sCD14), asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) were measured.RESULTS: ADMA and SDMA were associated with sCD14 but not lipopolysaccharide. There was a significant increase in ADMA and SDMA through tertiles of sCD14, and both markers were associated with sCD14 in multivariate linear regression analyses.CONCLUSIONS: Monocyte activation as measured by sCD14 is associated with endovascular dysfunction in HIV infection.",

keywords = "Adult, Aged, Anti-HIV Agents, Antigens, CD14, Antiretroviral Therapy, Highly Active, Arginine, Bacterial Translocation, Biological Markers, Cardiovascular Diseases, Female, Fibrin Fibrinogen Degradation Products, HIV Infections, Humans, Lipopolysaccharides, Male, Middle Aged, Monocytes",

author = "Pedersen, {Karin K} and Manner, {Ingjerd W} and Ingebj{\o}rg Seljeflot and Dag Kvale and Ingrid Os and Jan Gerstoft and Nielsen, {Susanne D} and Marius Tr{\o}seid",

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doi = "10.1097/QAI.0000000000000339",

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TY - JOUR

T1 - Monocyte Activation, but not Microbial Translocation, Is Independently Associated With Markers of Endovascular Dysfunction in HIV-Infected Patients Receiving cART

AU - Pedersen, Karin K

AU - Manner, Ingjerd W

AU - Seljeflot, Ingebjørg

AU - Kvale, Dag

AU - Os, Ingrid

AU - Gerstoft, Jan

AU - Nielsen, Susanne D

AU - Trøseid, Marius

PY - 2014/12/1

Y1 - 2014/12/1

N2 - BACKGROUND: Microbial translocation has been suggested as a driver of cardiovascular disease in HIV infection. We hypothesized that microbial translocation and the resulting monocyte activation would be associated with markers of endovascular dysfunction.METHODS: In 60 HIV-infected patients on combination antiretroviral therapy, plasma levels of lipopolysaccharide, soluble CD14 (sCD14), asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) were measured.RESULTS: ADMA and SDMA were associated with sCD14 but not lipopolysaccharide. There was a significant increase in ADMA and SDMA through tertiles of sCD14, and both markers were associated with sCD14 in multivariate linear regression analyses.CONCLUSIONS: Monocyte activation as measured by sCD14 is associated with endovascular dysfunction in HIV infection.

AB - BACKGROUND: Microbial translocation has been suggested as a driver of cardiovascular disease in HIV infection. We hypothesized that microbial translocation and the resulting monocyte activation would be associated with markers of endovascular dysfunction.METHODS: In 60 HIV-infected patients on combination antiretroviral therapy, plasma levels of lipopolysaccharide, soluble CD14 (sCD14), asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA) were measured.RESULTS: ADMA and SDMA were associated with sCD14 but not lipopolysaccharide. There was a significant increase in ADMA and SDMA through tertiles of sCD14, and both markers were associated with sCD14 in multivariate linear regression analyses.CONCLUSIONS: Monocyte activation as measured by sCD14 is associated with endovascular dysfunction in HIV infection.

KW - Adult

KW - Aged

KW - Anti-HIV Agents

KW - Antigens, CD14

KW - Antiretroviral Therapy, Highly Active

KW - Arginine

KW - Bacterial Translocation

KW - Biological Markers

KW - Cardiovascular Diseases

KW - Female

KW - Fibrin Fibrinogen Degradation Products

KW - HIV Infections

KW - Humans

KW - Lipopolysaccharides

KW - Male

KW - Middle Aged

KW - Monocytes

U2 - 10.1097/QAI.0000000000000339

DO - 10.1097/QAI.0000000000000339

M3 - Journal article

C2 - 25226210

SN - 1525-4135

VL - 67

SP - 370

EP - 374

JO - Journal of acquired immune deficiency syndromes (1999)

JF - Journal of acquired immune deficiency syndromes (1999)

IS - 4

ER -