Abstract
Diagnostic evaluations and early interventions of patients with bipolar disorder (BD) rely on clinical evaluations. Smartphones have been proposed to facilitate continuous and fine-grained self-monitoring of symptoms. The present study aimed to (1) validate daily smartphone-based self-monitored mood, activity, and sleep, against validated questionnaires and clinical ratings in young patients with newly diagnosed BD, unaffected relatives (UR), and healthy controls persons (HC); (2) investigate differences in daily smartphone-based self-monitored mood, activity, and sleep in young patients with newly diagnosed BD, UR, and HC; (3) investigate associations between self-monitored mood and self-monitored activity and sleep, respectively, in young patients with newly diagnosed BD. 105 young patients with newly diagnosed BD, 24 UR and 77 HC self-monitored 2 to 1077 days (median [IQR] = 65 [17.5–112.5]). There was a statistically significantly negative association between the mood item on Hamilton Depression Rating Scale (HAMD) and smartphone-based self-monitored mood (B = − 0.76, 95% CI − 0.91; − 0.63, p < 0.001) and between psychomotor item on HAMD and self-monitored activity (B = − 0.44, 95% CI − 0.63; − 0.25, p < 0.001). Smartphone-based self-monitored mood differed between young patients with newly diagnosed BD and HC (p < 0.001), and between UR and HC (p = 0.008) and was positively associated with smartphone-based self-reported activity (p < 0.001) and sleep duration (p < 0.001). The findings support the potential of smartphone-based self-monitoring of mood and activity as part of a biomarker for young patients with BD and UR. Smartphone-based self-monitored mood is better to discriminate between young patients with newly diagnosed BD and HC, and between UR and HC, compared with smartphone-based activity and sleep. Trial registration clinicaltrials.gov NCT0288826.
Originalsprog | Engelsk |
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Tidsskrift | European Child and Adolescent Psychiatry |
Vol/bind | 30 |
Sider (fra-til) | 1209–1221 |
ISSN | 1018-8827 |
DOI | |
Status | Udgivet - 2021 |
Bibliografisk note
Funding Information:Sigurd Arne Melbye is an early stage researcher of technology-enabled mental health (TEAM) for young people. This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie Grant agreement No. 722561 and the Copenhagen Center for Health Technology (CACHET). A special thanks goes out to all the participants in the study and the Copenhagen Affective Disorder Clinic, Psychiatric Center Copenhagen, Copenhagen University Hospital, Rigshospitalet, Denmark. Also, we wish to acknowledge the BIO team for assisting in recruiting of participants to the cohorts.
Funding Information:
This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie Grant agreement No. 722561 and the Copenhagen Center for Health Technology (CACHET). Acknowledgements
Publisher Copyright:
© 2020, The Author(s).