Mortality in HIV-infected injection drug users with active vs cleared hepatitis C virus-infection: a population-based cohort study

L H Omland; P Jepsen; N Weis; P B Christensen; A L Laursen; H Nielsen; H Krarup; H T Sørensen; N Obel

doi:10.1111/j.1365-2893.2009.01175.x

Mortality in HIV-infected injection drug users with active vs cleared hepatitis C virus-infection: a population-based cohort study

L H Omland, P Jepsen, N Weis, P B Christensen, A L Laursen, H Nielsen, H Krarup, H T Sørensen, N Obel

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › peer review

14 Citationer (Scopus)

Abstract

Udgivelsesdato: 2010-Apr

Originalsprog	Engelsk
Tidsskrift	Journal of Viral Hepatitis
Vol/bind	17
Udgave nummer	4
Sider (fra-til)	261-8
Antal sider	7
ISSN	1352-0504
DOI	https://doi.org/10.1111/j.1365-2893.2009.01175.x
Status	Udgivet - 2010

Bibliografisk note

Keywords: Adult; Cohort Studies; Denmark; Drug Users; Female; HIV Infections; Hepatitis C; Hepatitis Viruses; Humans; Male; Middle Aged; Substance Abuse, Intravenous; Survival Analysis

Adgang til dokumentet

10.1111/j.1365-2893.2009.01175.x

Citationsformater

Mortality in HIV-infected injection drug users with active vs cleared hepatitis C virus-infection: a population-based cohort study. / Omland, L H; Jepsen, P; Weis, N; Christensen, P B; Laursen, A L; Nielsen, H; Krarup, H; Sørensen, H T; Obel, N.

I: Journal of Viral Hepatitis, Bind 17, Nr. 4, 2010, s. 261-8.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › peer review

@article{2b0b9c10aac311df928f000ea68e967b,

title = "Mortality in HIV-infected injection drug users with active vs cleared hepatitis C virus-infection: a population-based cohort study",

abstract = "Acute hepatitis C virus (HCV) infection may lead to chronic HCV-infection with detectable HCV RNA or to spontaneous clearance with no HCV RNA, but detectable HCV antibodies. It is unknown whether HCV RNA status is associated with mortality in HIV-infected injection drug users (IDUs). We conducted a nationwide population-based cohort study to examine the impact of HCV RNA status on overall and cause-specific mortality in HIV-infected IDUs. We computed cumulative mortality and used Cox Regression to estimate mortality rate ratios (MRR). We identified 392 HIV-infected patients of whom 284 (72%) had chronic HCV-infection (HCV RNA positive patients) and 108 (28%) had cleared the HCV-infection (HCV RNA negative patients). During 1286 person-years of observation (PYR), 157 persons died (MR = 122/1000 PYR, 95% CI: 104-143). The estimated 5-year probabilities of survival were 0.58 (95% CI: 0.51-0.65) in the chronically HCV-infected and 0.52 (95% CI: 0.40-0.63) in the cleared HCV group. Chronic HCV-infection was not associated with overall mortality: MRR 0.85, 95% CI: 0.59-1.21. In HIV-infected Danish IDUs, chronic HCV-infection is not associated with increased mortality compared to patients who have cleared the infection.",

author = "Omland, {L H} and P Jepsen and N Weis and Christensen, {P B} and Laursen, {A L} and H Nielsen and H Krarup and S{\o}rensen, {H T} and N Obel",

note = "Keywords: Adult; Cohort Studies; Denmark; Drug Users; Female; HIV Infections; Hepatitis C; Hepatitis Viruses; Humans; Male; Middle Aged; Substance Abuse, Intravenous; Survival Analysis",

year = "2010",

doi = "10.1111/j.1365-2893.2009.01175.x",

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TY - JOUR

T1 - Mortality in HIV-infected injection drug users with active vs cleared hepatitis C virus-infection: a population-based cohort study

AU - Omland, L H

AU - Jepsen, P

AU - Weis, N

AU - Christensen, P B

AU - Laursen, A L

AU - Nielsen, H

AU - Krarup, H

AU - Sørensen, H T

AU - Obel, N

N1 - Keywords: Adult; Cohort Studies; Denmark; Drug Users; Female; HIV Infections; Hepatitis C; Hepatitis Viruses; Humans; Male; Middle Aged; Substance Abuse, Intravenous; Survival Analysis

PY - 2010

Y1 - 2010

N2 - Acute hepatitis C virus (HCV) infection may lead to chronic HCV-infection with detectable HCV RNA or to spontaneous clearance with no HCV RNA, but detectable HCV antibodies. It is unknown whether HCV RNA status is associated with mortality in HIV-infected injection drug users (IDUs). We conducted a nationwide population-based cohort study to examine the impact of HCV RNA status on overall and cause-specific mortality in HIV-infected IDUs. We computed cumulative mortality and used Cox Regression to estimate mortality rate ratios (MRR). We identified 392 HIV-infected patients of whom 284 (72%) had chronic HCV-infection (HCV RNA positive patients) and 108 (28%) had cleared the HCV-infection (HCV RNA negative patients). During 1286 person-years of observation (PYR), 157 persons died (MR = 122/1000 PYR, 95% CI: 104-143). The estimated 5-year probabilities of survival were 0.58 (95% CI: 0.51-0.65) in the chronically HCV-infected and 0.52 (95% CI: 0.40-0.63) in the cleared HCV group. Chronic HCV-infection was not associated with overall mortality: MRR 0.85, 95% CI: 0.59-1.21. In HIV-infected Danish IDUs, chronic HCV-infection is not associated with increased mortality compared to patients who have cleared the infection.

AB - Acute hepatitis C virus (HCV) infection may lead to chronic HCV-infection with detectable HCV RNA or to spontaneous clearance with no HCV RNA, but detectable HCV antibodies. It is unknown whether HCV RNA status is associated with mortality in HIV-infected injection drug users (IDUs). We conducted a nationwide population-based cohort study to examine the impact of HCV RNA status on overall and cause-specific mortality in HIV-infected IDUs. We computed cumulative mortality and used Cox Regression to estimate mortality rate ratios (MRR). We identified 392 HIV-infected patients of whom 284 (72%) had chronic HCV-infection (HCV RNA positive patients) and 108 (28%) had cleared the HCV-infection (HCV RNA negative patients). During 1286 person-years of observation (PYR), 157 persons died (MR = 122/1000 PYR, 95% CI: 104-143). The estimated 5-year probabilities of survival were 0.58 (95% CI: 0.51-0.65) in the chronically HCV-infected and 0.52 (95% CI: 0.40-0.63) in the cleared HCV group. Chronic HCV-infection was not associated with overall mortality: MRR 0.85, 95% CI: 0.59-1.21. In HIV-infected Danish IDUs, chronic HCV-infection is not associated with increased mortality compared to patients who have cleared the infection.

U2 - 10.1111/j.1365-2893.2009.01175.x

DO - 10.1111/j.1365-2893.2009.01175.x

M3 - Journal article

C2 - 19709359

VL - 17

SP - 261

EP - 268

JO - Journal of Viral Hepatitis

JF - Journal of Viral Hepatitis

SN - 1352-0504

IS - 4

ER -